Preserving Hyperpolarization of 129 Xe for Transport Zach Zytner Project Supervisor: Giles Santyr Medical Biophysics 3970 March 23, 2011.

Slides:

Advertisements

Similar presentations

Pulse Timing parameters & Weighting

Advertisements

Fund BioImag : Echo formation and spatial encoding 1.What makes the magnetic resonance signal spatially dependent ? 2.How is the position of.

Gas NMR Characterization of Oil Shale

Fund BioImag : Echo formation and spatial encoding 1.What makes the magnetic resonance signal spatially dependent ? 2.How is the position of.

Contrast T1 weighted – (MPRAGE-anatomical) T2 weighted – (fmri)

MRI Phillip W Patton, Ph.D..

BE 581 Lecture 3- Intro to MRI.

PHYSICS OF MAGNETIC RESONANCE

Magnetic Resonance Imaging - MRI

Nuclei With Spin Align in Magnetic Fields HoHo anti-parallel parallel Alignment Energy  E = h  H o Efficiency factor- nucleus ConstantsStrength of magnet.

MR TRACKING METHODS Dr. Dan Gamliel, Dept. of Medical Physics,

The importance of MRI, a few numbers  MRI units worldwide in 2003  75 millions scans per year performed  Constant need for over 1000 MRI technologists.

Parameters and Trade-offs

San Jose, California USA

NMR Spectroscopy Part I. Origin of NMR. Nuclei in Magnetic Field Nucleus rotate about an axis -- spin Nucleus bears a charge, its spin gives rise to a.

Lecture 2 1 H Nuclear Magnetic Resonance. Gas Chromatograph of Molecular Hydrogen at –100 °C Thermoconductivity Detector 12.

Relaxation Exponential time constants T1 T2 T2*

Nuclear Magnetic Resonance Spectrometry Chap 19. Absorption in CW Experiments Energy of precessing particle E = -μ z B o = -μ B o cos θ When an RF photon.

Noise near peak field is increased Peak width narrow Peak is symmetric Purpose: Resonate nuclei to prevent polarization. Matching the resonant frequencies.

I.1 ii.2 iii.3 iv.4 1+1=. i.1 ii.2 iii.3 iv.4 1+1=

Basics of Magnetic Resonance Imaging

Computed Tomography. Introduced in 70’s Principle: Internal structures of an object can be reconstructed from multiple projections of the object.

I.1 ii.2 iii.3 iv.4 1+1=. i.1 ii.2 iii.3 iv.4 1+1=

Magnetic Resonance MSN 506 Notes. Overview Essential magnetic resonance Measurement of magnetic resonance Spectroscopic information obtained by magnetic.

SPIN 2004 Oct. 14, 2004 W. Kim, S.S. Stepanyan, S. Woo, M. Rasulbaev, S. Jin (Kyungpook National University) S. Korea Polarization Measurements of the.

Magnetic Resonance Imaging

Principles of Magnetic Resonance

Prof. Dr. Moustafa. M. Mohamed Dr. Eng. Safa Ahmed El-Askary

Chapter 4 Mark D. Herbst, M.D., Ph.D.. Magnetization MRI depends on magnetization of tissues Temporary magnetization occurs when the hydrogen nuclei are.

September, 2003BME 1450 Introduction to NMR 1 Nuclear Magnetic Resonance (NMR) is a phenomenon discovered about 60 years ago.

NMR in Medicine and Biology

Human Functional Brain Imaging Dr. Ryan C.N. D’Arcy NRC Institute for Biodiagnostics (Atlantic)

Considerations for the Optimal Polarization of 3 He Targets Brielin C. Brown University of Virginia October 10, 2008 SPIN 2008.

Sarah Newton University of Oregon Applied Physics.

Pei-Ann Lin and PJ Velez December 13, 2011

Ultrahigh precision observation of nuclear spin precession and application to EDM measurement T. Inoue, T. Furukawa, H. Hayashi, M. Tsuchiya, T. Nanao,

Introduction The nucleus of a hydrogen atom has magnetic dipole moment and spin angular momentum. When placed in an external magnetic field, two distinct.

1 Introduction to Magnetic Resonance Imaging درس مقدمه ای بر فیزیک پزشکی Sahand University of Technology Faculty of Electrical Engineering M. Shamsi.

Low-frequency nuclear spin maser and search for atomic EDM of 129 Xe A. Yoshimi RIKEN SPIN /10/11-16 Trieste, ITALY Collaborator : K. Asahi (Professor,

Beam Polarimetry Matthew Musgrave NPDGamma Collaboration Meeting Oak Ridge National Laboratory Oct. 15, 2010.

The number of protons yielding correlations in a 2D NOESY spectrum quickly overwhelms the space available on A 2D map. 15N labeling can help simplify the.

Low–field NMR (or MRI) Images of Laser polarized Noble Gas.

MRI Physics Dr Mohamed El Safwany, MD.. MRI Magnetic Resonance Imaging Magnetic Resonance Imaging.

3 He cell production at NIST M. Jon Dadras. Outline Basics of a 3 He cells Basics of a 3 He cells Blowing/Baking Blowing/Baking Filling Filling Uses Uses.

Indiana University Cyclotron Facility March, 2004 EIC WorkshopV.P.Derenchuk 1 Polarized Ion Sources V.Derenchuk, Ya.Derbenev, V.Dudnikov Second Electron-Ion.

The polarized target for G E n Gordon D. Cates, Jr. University of Virginia Professor of Physics and Radiology G E n, - October 24, 2003.

Functional Brain Signal Processing: EEG & fMRI Lesson 11 Kaushik Majumdar Indian Statistical Institute Bangalore Center M.Tech.

Determining Whole Lung Perfusion Using Hyperpolarized Xe-129 MRI Ian Gerard Department of Medical Biophysics University Of Western Ontario Six Week Project.

V.G.Wimalasena Principal School of Radiography

Fund BioImag : Relaxation of nuclear magnetization 1.How is the MR signal detected ? 2.What is the quantum-mechanical equivalent of the rotating.

Wave Motion Types waves –mechanical waves require a medium to propagate –sound wave, water wave –electromagnetic waves not require a medium to propagate.

SONA Transition Optimization in the Brookhaven OPPIS A. Kponou, A. Zelenski, S. Kokhanovski, V. Zubets & T. Lehn B. N. L.

R Wyllie, R Wakai, T G Walker University of Wisconsin, Madison Spin-Exchange Relaxation Free Heart signal frequency spectrum from DC-100Hz Adult heart.

RT 4912 Review (C) Rex T. Christensen MHA RT (R) (MR) (CT) (ARRT) CIIP.

Magnetic Resonance Imaging Glenn Pierce, King’s College London, Department of Physics Introduction Edward Purcell and Felix Bloch were both awarded the.

Magnetic Resonance Learning Objectives

Anna Korver, Dan Thrasher, and Thad Walker Northrop-Grumman Review September

In vivo MRI of Fast Relaxing Spins Using a Swept Radiofrequency Djaudat Idiyatullin, Curt Corum, Jang-Yeon Park, Michael Garwood Center for Magnetic Resonance.

 This depends on a property of nuclei called spin.  Gyroscope: Principle: As long as its disc remains spinning rapidly the direction of the spin axis.

MAGNETIC RESONANCE IMAGING by PRADEEP V.EPAKAYAL. Mem.no L.

J. Ardila, R. Albarracín, J.M. Martínez-Tarifa, G. Robles.

IMAGE ORTHICON.

MRI Physics in a Nutshell Christian Schwarzbauer

MRI image GUI: Final Project SIMG 726

Medical Application of Spin-Polarized Noble Gases: Emphysema Index Based on Polarized He-3 and Xe-129 Diffusion in the Lung Sina Tafti , William J Garrison,

Magnetism from Electricity

Structure determination by NMR

Introduction to MR Robert Frost

(4)ELECTRONIC SUPPORT SYSTEM

Introduction to MR Robert Frost

Presentation transcript:

Preserving Hyperpolarization of 129 Xe for Transport Zach Zytner Project Supervisor: Giles Santyr Medical Biophysics 3970 March 23, 2011

Introduction MR imaging with hyperpolarized noble gases – Greater resolution in lung imaging without harmful radiation – Effectiveness depends on nuclei high-spin polarization achieved outside system Preserving the 129 Xe polarization permits transporting the HNG to other research sites

Transportation Box Solenoid coil 12V NiMH Battery Glass vial Current control Current display (mA) Power switch Recharging terminal Solenoid coil (ID 15.3cm) Power supply (battery mA)

Method I: Project Layout Xe sample Solenoid coil Sustainability of battery Collection of polarized Xe Signal data at time intervals through polarimetry Determination of box’s T 1

Method II: Mapping the Field with Current Maximum current = 1650 mA Maximum field = 36.5 G (3.65 mT)

Method III: Characterizing Field vs. Time 18 hour charge shows rapid decay of field Best charging time shows box can maintain magnetic field

Polarimetry Station Helmholtz Coil RF coilStage for gas sample Pulse and response frequencies within 50Hz for accurate measurement of signal

Longitudinal Spin Relaxation Optical pumping of Rb followed by spin exchange with Xe nucleus Longitudinal relaxation time (T1) is the time taken to return to equilibrium within the lattice after an RF pulse excitation

Results I: Signal for 90mL Xe bag at t = 2 mins

Results II: Signal for 90mL Xe bag at t = 122 mins

Results III: Response Amplitude from Excel Trend Lines vs. Time Extrapolated t = 0 is 27.5mV Signal = 5.37 mV at 122 mins

Results IV: Response Amplitude from Polarimetry Software Trend Lines vs. Time Extrapolated t = 0 is 43.1 mV Signal = 2 mV at 122 mins

Results V: T 1 Determination Signal from Excel trend lines T 1 = 75 mins = 1.25 hrs Signal from polarimetry software trend lines T 1 = 40 mins = 0.67 hrs

Discussion With the current battery, transportation box must be charged more than 24 hours to maintain a sustainable magnetic field Signals obtained from the station is contaminated with noise With the current signals at ~ t = 0, T 1 found to be minutes

Conclusions The transportation box could likely preserve hyperpolarization in 129 Xe if travelling short distances Recommendation: use battery with long life with short charging time

Acknowledgements Giles Santyr Adam Farag Mathieu Boudreau Alexei Ouriadov Matthew Fox Marcus Couch Julie Tanguay Ian Gerard Elaine Hegarty Funding: