Confidential. Boston Biomedical Innovation Center. All Rights Reserved. Boston Biomedical Innovation Center (B-BIC) 1 A unique consortium of academia,

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Confidential. Boston Biomedical Innovation Center. All Rights Reserved. Boston Biomedical Innovation Center (B-BIC) 1 A unique consortium of academia, government, non-profits, industry, and venture capital PIs: Joe Loscalzo, MD, PhD, BWH ; John Parrish, MD, MGH & CIMIT ; David Golan, MD, PhD, HMS

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. Boston Biomedical Innovation Center (B-BIC) 2 Supports academic investigators developing devices, diagnostics, and therapeutics addressing heart, lung, blood and sleep disorders An NIH National Center for Accelerated Innovation (NCAI)

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. B-BIC Is Focused on Commercialization 3 Accelerates translational research, and address gaps in early-stage funding, access to external resources/expertise, and commercialization skills AcademiaCommercial Sector B-BIC Activities & Partnerships

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. B-BIC Provides Significant Support to Investigators 4 PILOT grant Up to $50,000 plus overhead, Proof-of-concept, 1 year Rolling submission DRIVE grant Up to $200,000 plus overhead, Proof-of-value, 1½ - 2 yrs Rolling submission Customized education for individuals; Broad education for all Customized milestone & critical path development; Commercialization & IP strategies & tactics Project Management, Coaching Skills Development Grant Funding External Partnering Development FDA, CMS, USPTO, OTAC Commercialization Industry, Venture Capital

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. PM = = SD 5 PI t + BBICfPI t Co – – Co – Co – A more scientific framework… Energy, Time – EP – – –

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. B-BIC Grant Recipients A Blood Coagulation Sensor for Point of Care Use Seemantini Nadkarni, PhD, Wellman Center, Massachusetts General Hosp. A Biomimetic Human Platelet Bioreactor Jonathan Thon, PhD, BWH, and Joseph Italiano, PhD, BWH Portable MR Device for the Pulmonary ICU Samuel Patz, PhD, Brigham and Women’s Hospital Development of an Implantable Intracardiac Robotic Right Ventricular Ejection Device Nikolay Vasilyev, MD, Boston Children’s Hospital 6

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. B-BIC Proposal Development & Review Process 7 B-BIC supports investigators throughout the grant submission process Full Proposal Full Proposal Coaching on market analysis, clinical applications, IP, commercialization, technology Key milestones and project critical path developed Skills development consultation Pre- Proposal External Review Federal Partners Award Decision

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. How To Get Engaged with B-BIC Visit: 8

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. B-BIC Website 9

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. How To Get Engaged with B-BIC Contact B-BIC resources: Site Miner, Domain Expert, Lesley Watts or Paul Tessier (contact info on web site) Submit pre-proposal: Work with B-BIC resources 10

Confidential. Boston Biomedical Innovation Center. All Rights Reserved. How To Get Engaged with B-BIC 11