Intelligent Automation

Who are PAA ?

Who are Process Analysis & Automation ? Incorporated in 1992 Software supplier, OVERLORD Offer systems integration services Independent automation supplier Experienced in multi-vendor platforms – PE/GE/Thermo/Caliper/Tecan/Beckman/Hamilton – Drivers for 75+ manufacturers, 230+ instruments Unique software solutions – Tried and tested, over 400 sold worldwide

Laboratory Automation Experience

Intelligent Automation Why do we automate ?

Speed Reliability – Small workstations Extend instrument operating hours Cost effective analysis Data and sample tracking

The tools Laboratory robot Storage Liquid handling Barcode reader Shaker Luminex

Hardware list – Robots 1

automate.it SCARA Hardware list – Robots 2 PE PlateStakMitsubishi

Hardware list - Storage Incubator Storage

Hardware list – Liquid Handling Reagent dispensing Flexdrop Liquid Handling PlateWash

Hardware list – Other peripherals Barcode reader Plate reader

Intelligent Automation What automation to offer ?

Listen to customer – Some want ‘off the shelf’ solution – Some want full flexibility – Some want simple – Some have no idea what they need Sell them what they ask for !

Control Software Real-time scheduling – Overlord2 – Event driven Time-resolved scheduling – OVERLORD Scheduler – Time driven either schedul er Bio-Rad

Intelligent Automation What is OVERLORD ?

What is Overlord? Suite of Automation software by PAA Product range is 10 years old Support for more than 230 instruments Two main products – Workstation – Scheduler

Common features Support for over 230 instruments Data handling facilities Utilizes original instrument software Can integrate with most databases – SQL Server, Oracle, Access 21 CFR Part 11 Compliant Full system tracking Error notification Error Recovery

Which product ? AdvantagesDisadvantages Overlord 2 Very Flexible True Dynamic Scheduling Takes longer to setup OVERLORD Scheduler Very easy to use Obeys critical timings Schedules fixed processes Cannot make decisions Most suitable

OVERLORD Scheduler

Static/time driven Icon based drag and drop Gantt chart interface Can optimise and interleave different assays within a single run Each assay run with exact incubation timings Very easy to create an assay Add new assays when the system is running

Overlord2

dynamic/real-time/event Icon based drag and drop set-up Flow chart interface Very flexible Dynamic scheduling – decisions can be made in real-time

Overlord2 - Model Common Model through application Procedures defined that contain Actions Actions define how to run a Command Commands are: – Instruments – Plugins – Flow Control

Overlord2 - Runtime Executes Procedures from the Model Processes the Flow using Overlord variables All errors handled with different options More Run Engines planned

Overlord2 - Customizable Overlord drivers quickly ALL components can be modified Different Run Engines can be run Can use different GUI, Excel could be used Master or slave.NET Framework, API will be utilized This technology helps writing instrument drivers Fresh ideas for the UI to make writing assays easier

Overlord2 - Summary OVERLORD Workstation was a mature product Overlord2 based upon.NET Framework Common Model Different Run Engines can be used Components can customized

Intelligent Automation Example Systems

Example systems Mitsubishi Robot Bulk dispenser Plate storage Accurate dispenser Plate reader Safety cabinet

Other peripherals Plate sealer Plate storage Plate access

with Twister II

with automate.it SCARA

Intelligent Automation Bio-Rad example

Intelligent Automation What extra can PAA offer ?

What extra can PAA offer customers ? What happens before the plate read ? – Automation expertise – Customer specific user interfaces What happens after the plate read ? – Data handling expertise – Post run data manipulation – Database interaction Installation expertise – Highly experienced installation team – All our installation engineers are also programmers

Intelligent Automation How can PAA help ?

How can PAA help Bio-Rad ? Discuss the leads by /Skype – PAA may have done it before – PAA may have specialist knowledge to make the Bio-Rad option sexy versus the competition Allow PAA to demonstrate the solution by Web Flexible customer orientated automation solutions