World-renowned Authors Relevant Content UpToDate’s Value Proposition Easy to Use UpToDate synthesizes the most recent medical information into evidence-based, practical recommendations clinicians trust to make the right point-of-care decisions.

9,000+ topics in 18 specialties Additional 5,000+ unique drug entries 700+ patient information topics 4,800+ physician authors, editors and peer reviewers 7,700+ graded recommendations 450,000+ users in 149 countries UpToDate Facts-at-a-Glance

Adult and Pediatric Emergency Medicine Adult Primary Care and Internal Medicine Allergy and Immunology Cardiovascular Medicine Dermatology* Endocrinology and Diabetes Family Medicine Gastroenterology and Hepatology Geriatrics Hematology Hospital Medicine Specialties Covered in UpToDate Infectious Diseases Nephrology and Hypertension Neurology Obstetrics, Gynecology and Women’s Health Oncology Pediatrics Psychiatry* Pulmonary, Critical Care and Sleep Medicine Rheumatology Surgery* *In development

UpToDate has users in 149 countries UpToDate Is Trusted Worldwide

UpToDate’s Editorial Process Authored and edited by leading physicians World-renowned expertise Hand-searching of 460+ journals Three-tiered peer review process

UpToDate’s Editorial Process UpToDate Editorial Process Our authors collaborate with multiple specialty editors to create or update the topic. Final topic content consensus is reached. New clinical studies are released that impact care. Topic is available to clinicians worldwide via UpToDate. The topic is peer-reviewed. A grading editor reviews the graded recommendations.

Graded Recommendations Grades denote strength of recommendation and quality of evidence Strong recommendation = Grade 1 [ “We recommend” ] Weak recommendation = Grade 2 [ “We suggest” ] Evidence = Grade A, B or C [ High, moderate or low quality ]

Hierarchy of Evidence High - Quality Low - Quality Meta-analyses of randomized trials of high methodological quality Randomized trials with methodological limitations Observational studies Unsystematic clinical observations Graded Recommendations

Users Say UpToDate Improves Care 89% changed management 94% improves quality of care 81% changed diagnostic testing 0%20%40%60%80%100% Source: UpToDate Subscriber Survey, 2010

UpToDate “changes the way you practice medicine — really.” Medical Professionals Endorse UpToDate Pam Wetzel, MD Chief Medical Information Officer Swedish American Hospital, Rockford, IL

Marc Greenwald, MD Chief of Medicine Signature Healthcare-Brockton Hospital, Brockton, MA Medical Professionals Endorse UpToDate UpToDate “applicability to patients is in evidence every day.”

R.M. Valentijn, MDMDHAGA Hospital, the Hague, the Netherlands “UpToDate is …a new way of practicing medicine … for day-to-day practice there is no other product.” Medical Professionals Endorse UpToDate