Hantavirus. Center for Food Security and Public Health Iowa State University - 2004 Overview Organism History Epidemiology Transmission Disease in Humans.

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Presentation transcript:

Hantavirus

Center for Food Security and Public Health Iowa State University Overview Organism History Epidemiology Transmission Disease in Humans Disease in Animals Prevention and Control

The Organism

Center for Food Security and Public Health Iowa State University Hantaviruses Family Bunyaviridae − RNA virus − Genus Hantavirus  Only genus not arthropod-borne  Transmitted by murid rodents More than 25 hantavirus species

Center for Food Security and Public Health Iowa State University Hantaviruses Lipid envelope − Deactivated by ordinary disinfectants A “viral hemorrhagic fever” − Hantavirus Pulmonary Syndrome (HPS) − Hemorrhagic Fever with Renal Syndrome (HFRS)

Center for Food Security and Public Health Iowa State University Hantaviruses in the Old World SerotypeHostLocation Hantaan Apodemus agrarius (striped field mouse) Asia, Far East Russia Dobrava A. agrarius, A. flavicollis (yellow neck mouse) Europe Balkans Seoul Rattus norvegicus, R. rattus (Norway brown rat, roof rat) Worldwide Puumala Clethrionomys glareolus (red bank vole) Europe

Center for Food Security and Public Health Iowa State University Hantaviruses in the New World Serotype Host Location Sin NombrePeromyscus maniculatus (deer mouse) Central & West U.S., Canada MonongahelaPeromyscus maniculatus (deer mouse) Eastern U.S., Canada New YorkPeromyscus leucopus (white-footed mouse) Eastern U.S., Canada BayouOryzomys palustris (rice rat) SE U.S. Black Creek Canal Sigmodon hispidus (cotton rat) SE U.S.

Center for Food Security and Public Health Iowa State University Hantaviruses in the New World SerotypeHost Location AndesOligoryzomys longicaudatus (long- tailed pygmy rice rat) Argentina/Chile OranO. longicaudatusNW Argentina LechiguanasO. flavescensCentral Argentina Hu39694UnknownCentral Argentina Laguna Negra Calomys lauchaParaguay/ Bolivia JuquitibaUnknownBrazil *Numerous other hantaviruses have been identified but not linked to human disease

Center for Food Security and Public Health Iowa State University Sin Nombre Peromyscus maniculatus Rio Segundo Reithrodontomys mexicanus El Moro Canyon Reithrodontomys megalotis Andes Oligoryzomys longicaudatus Bayou Oryzomys palustris Black Creek Canal Sigmodon hispidus Rio Mamore Oligoryzomys microtis Laguna Negra Calomys laucha Muleshoe Sigmodon hispidus New York Peromyscus leucopus Juquitiba Unknown Host Maciel Necromys benefactus Hu39694 Unknown Host Lechiguanas Oligoryzomys flavescens Pergamino Akodon azarae Orán Oligoryzomys longicaudatus Caño Delgadito Sigmodon alstoni Isla Vista Microtus californicus Bloodland Lake Microtus ochrogaster Prospect Hill Microtus pennsylvanicus New World Hantaviruses Bermejo Oligoryzomys chacoensis

History

Center for Food Security and Public Health Iowa State University Hantaviruses in Our Past American Civil War World Wars I and II 1913, 1932 − Russia reported cases 1934 − Sweden - Nephropathia Endemica 1950’s − Reports of Korean Hemorrhagic Fever

Center for Food Security and Public Health Iowa State University Hemorrhagic Fever with Renal Syndrome (HFRS) : Korean War − 3,200 U.N. troops develop disease − Hantaan River separated N. & S. Korea 1977 − Hantaan agent isolated and characterized − 1990: 94% of serum samples from soldiers in 1950’s had antibodies 1979 − Seoul virus found in Japan and Europe

Center for Food Security and Public Health Iowa State University U.S.: Four Corners Outbreak

Center for Food Security and Public Health Iowa State University The Four Corners Outbreak May 1993 − First clinical case − Abrupt fever, myalgia, pulmonary edema June 1993 − 12 fatalities − Unexplained Adult Respiratory Distress Syndrome (ARDS) − Sera cross-reacted with Hantaan, Seoul, Puumala virus − Rodents trapped - deer mouse main reservoir

Center for Food Security and Public Health Iowa State University The Four Corners Outbreak Winter and spring 1993 − Drought for several years followed by snow and rain − Vegetation blossomed and rodent population grew tenfold Virus isolated and named − Sin Nombre Virus (SNV) Newly emerging virus has been present since 1959 − 38 year old Utah man

Center for Food Security and Public Health Iowa State University Epidemic Curve of Four Corners Outbreak

Center for Food Security and Public Health Iowa State University Recent Cases May 2003: Montana − Three cases  Two deaths  Contracted virus from rodents in home  First cases since fall of 2001 − Overall cases in Montana  Virus first appeared in state in cases 5 deaths

Epidemiology

Center for Food Security and Public Health Iowa State University Common Rodent Reservoirs United States, except the Southeast − Deer mouse (Peromyscus maniculatus) Southeast United States − Cotton rat (Sigmodon hispidus) − Rice rat (Oryzomys palustris) Eastern − White-footed mouse (Peromyscus leucopus) House mouse not a carrier!

Center for Food Security and Public Health Iowa State University Cotton Rat Sigmodon hispidus Deer Mouse Peromyscus maniculatus House Mouse Mus musculus L.L. Masters

Center for Food Security and Public Health Iowa State University

Striped field mouse Apodemus agrarius Hantaan Virus Reservoir

Center for Food Security and Public Health Iowa State University Although serologically confirmed as HPS, sequence data are not available for all cases. For non-sequenced cases, the specific infecting hantavirus is assumed to be that corresponding with the known rodent reservoir in the area of probable exposure. Location of HPS Cases by Virus Types: July 6, 2004 Total Cases (N=366 in 31 States)

Center for Food Security and Public Health Iowa State University Distribution* of Peromyscus maniculatus and HPS Cases as of July 6, 2004 Total Cases (N=366 in 31 States) *Rodent distributions from: Burt WH, Grossenheider RP. A Field Guide to the Mammals. 3rd ed. New York, New York. Houghton Mifflin Company. 1980

Center for Food Security and Public Health Iowa State University Distribution* of Oryzomys palustris and Location of HPS Cases as of July 6, 2004 *Rodent distributions from: Burt WH, Grossenheider RP. A Field Guide to the Mammals. 3rd ed. New York, New York. Houghton Mifflin Company Total Cases (N=366 in 31 States)

Center for Food Security and Public Health Iowa State University *Rodent distributions from: Burt WH, Grossenheider RP. A Field Guide to the Mammals. 3rd ed. New York, New York. Houghton Mifflin Company Distribution* of Peromyscus leucopus and HPS Cases as of July 6, 2004 Total Cases (N=366 in 31 States)

Center for Food Security and Public Health Iowa State University Distribution* of Sigmodon hispidus and HPS Cases as of July 6, 2004 *Rodent distributions from: Burt WH, Grossenheider RP. A Field Guide to the Mammals. 3rd ed. New York, New York. Houghton Mifflin Company Total Cases (N=366 in 31 States)

Center for Food Security and Public Health Iowa State University HPS Cases by State of Residence U.S.: July 6, 2004 Total Cases (N=366 in 31 States)

Center for Food Security and Public Health Iowa State University HPS Case Count North & South America − 1500 cases United States and Canada − Sin Nombre Virus  Majority of cases − Others implicated  Andes, Monongahela, Black Creek Canal, Bayou, and New York viruses − Rodent-to-human transmission

Center for Food Security and Public Health Iowa State University HPS Case Count, U.S. United States − 31 states have reported cases − Occur throughout the year  More common in spring-summer − 75% of patients reside in rural areas − 62% male; 38% female − Mean age of confirmed case is 37 − Mortality rate 38% − Notifiable disease

Center for Food Security and Public Health Iowa State University Non-Sin Nombre HPS Viruses Black Creek Canal Virus − Cotton rat (Sigmodon hispidus) − One case in a Florida man Bayou Virus − Rice rat (Oryzomys palustris) − 4 cases in Louisiana, Texas New York-1 Virus − Deer mouse (P. maniculatus), white footed mouse (P. leucopus) − 2 cases in New York

Center for Food Security and Public Health Iowa State University Armstrong, L.R. et al., JID 1995; 172 (October) Peridomestic exposure Peridomestic & occupational exposure Peridomestic & recreational exposure Occupational exposure Entering/cleaning rodent-infested structures 69% (48/70) 19% (13/70) 9% (6/70) 4% (3/70) 9% (6/70) Rodent Exposures and HPS 70 confirmed HPS cases

Center for Food Security and Public Health Iowa State University Risk of Contracting HPS Relatively low Contact with rodent excrement puts you at greatest risk − Cleaning a rodent infested dwelling − Opening or cleaning buildings that have been closed for a while  Especially over winter

Center for Food Security and Public Health Iowa State University Risk of Contracting HPS Work, play, or live in closed spaces where rodents are actively living Hikers and campers Construction and utility workers − Enter crawl spaces under buildings − No serological evidence in 522 samples Traveling to and within hantavirus areas is not a risk factor

Center for Food Security and Public Health Iowa State University N Male Female 366 (100%) 227 (62%) 139 (38%) White284 (78%) American Indian71 ( 19%) Black Asian 3 ( 1%) Hispanic45 (12%) Dead 135 (37%) Age ( years ) 6 ( 2%) HPS U.S. Descriptive Demographic Statistics: July 6, 2003 Mean=37 [10-75]

Center for Food Security and Public Health Iowa State University Reported Cases Year

Center for Food Security and Public Health Iowa State University November 1998

Center for Food Security and Public Health Iowa State University HFRS Worldwide − 150,000–200,000 cases/yr Korean Hemorrhagic Fever − South Korea  cases annually − Eastern China  ~100,000 cases annually Outbreaks linked to contact with field rodents during planting and harvesting of crops

Transmission

Center for Food Security and Public Health Iowa State University Chronically infected rodent Virus is present in aerosolized excreta, particularly urine Horizontal transmission of infection between same species by contact Secondary aerosols, mucous membrane contact, and skin breaches are also a consideration Transmission of Hantaviruses

Center for Food Security and Public Health Iowa State University Transmission of Hantaviruses Non-rodent animals may test positive − Do not excrete viral particles − Some species may introduce rodents into domestic setting Person-to-person transmission rare − Not through blood transfusion or vectors − Southern Argentina case Lab acquired (several cases)

Disease in Humans

Center for Food Security and Public Health Iowa State University Clinical Signs of HPS Incubation period − days Early stage − Fatigue, fever, myalgia, headache  Lasts 3-5 days − Half of the patients experience headaches, dizziness, chills, nausea, vomiting, diarrhea, abdominal pain

Center for Food Security and Public Health Iowa State University Clinical Signs of HPS Later stage − 4 to 10 days after initial signs − Coughing and shortness of breath − Rapidly progressive, non-cardiogenic pulmonary edema and severe hypotension − Hospitalization and ventilation required usually within 24 hours

Center for Food Security and Public Health Iowa State University Clinical Signs of HPS Tachypnea, tachycardia Hypotension Crackles or rales on lung examination Lowered albumin, elevated hematocrit Elevated WBC count Platelet count below 150,000 units

Center for Food Security and Public Health Iowa State University HPS Radiographic Findings Bilateral interstitial infiltrates − Moderate to rapid progression Bilateral alveolar infiltrates Pleural effusion Normal heart size

Center for Food Security and Public Health Iowa State University May 27, 1993 May 30, 1993 May 31, 1993 Source: Dr. L. Ketai Radiographic Progression of HPS

Center for Food Security and Public Health Iowa State University HPS National Surveillance Inclusion Criteria Healthy person with febrile illness; Unexplained acute respiratory distress syndrome OR bilateral interstitial lung infiltrates Supplemental oxygen OR death from unexplained respiratory illness AND noncardiogenic pulmonary edema at autopsy AND no identifiable, specific cause of death

Center for Food Security and Public Health Iowa State University HPS National Surveillance Exclusion Criteria Predisposing underlying medical condition Acute illness that explains the respiratory disease

Center for Food Security and Public Health Iowa State University HPS National Surveillance Confirmation requires meeting all inclusion and exclusion criteria Plus laboratory confirmation − Positive serology − Positive PCR − Positive IHC

Center for Food Security and Public Health Iowa State University Clinical Signs of HFRS Febrile phase − Abrupt onset of chills, lethargy, sustained high fever − Headache, myalgia, vomiting, diarrhea − Thrombocytopenia, petechial hemorrhages Hypotensive phase − Increased hematocrit − Sinus bradycardia

Center for Food Security and Public Health Iowa State University Clinical Signs of HFRS Oliguric phase − Lowered urine output − Increased serum urea and creatinine − Death due to circulatory or renal failure Diuretic phase − Spontaneous Convalescent phase − Unable to concentrate urine

Center for Food Security and Public Health Iowa State University Other HFRS Clinical Signs Hantaan, Seoul, Dobrava viruses − Severe hemorrhagic complications Puumala virus − Nephropathia Epidemica  Acute febrile disease with renal involvement  Transient thrombocytopenia

Center for Food Security and Public Health Iowa State University Diagnosis Serology − ELISA used by CDC  IgM, IgG Immunohistochemistry − Detects viral antigen in tissues Virus isolation Various others

Center for Food Security and Public Health Iowa State University HPS Treatment Early, aggressive intensive care Avoidance of hypoxia − Assisted ventilation Electrolyte balance Maintaining normal blood pressure Ribavirin has questionable efficacy Careful monitoring

Center for Food Security and Public Health Iowa State University HPS Prognosis Patients can recover − With early supportive care Grave prognosis − If undiagnosed or do not seek treatment Chronic lung and heart damage − Can result depending on the type and aggressiveness of supportive care

Center for Food Security and Public Health Iowa State University Case February 2000 − 61 year old rural Vermont resident − Episodes of fever, chills, syncope − Hospitalized  Swollen lymph node, sore knee  Abnormal CBC, normal lung radiographs − Progressed to respiratory failure  Interstitial edema, mechanical ventilation

Center for Food Security and Public Health Iowa State University Case Renal insufficiency, DIC − Released after 23 days Initial diagnosis − Adult Respiratory Distress Syndrome with sepsis Further Investigation − Contact with rodent excrement − Paired serum samples positive for SNV 5% of HPS cases occur east of Mississippi River

Disease in Animals

Center for Food Security and Public Health Iowa State University Disease in Animals Rodents − Reservoir − Asymptomatic carriers − Antigen present in virtually all organs − Infectious for life Other mammals seronegative

Prevention and Control

Center for Food Security and Public Health Iowa State University HPS Prevention Limit exposure to mouse excrement Control rodents indoors Control rodents outdoors Use safety precautions when cleaning rodent infested areas Minimize your exposure when enjoying outdoor activities

Center for Food Security and Public Health Iowa State University Control Mice Indoors Prevent access to food sources − Keep food preparation and cooking areas clean − Cover pet and human food overnight − Store garbage in tightly covered or elevated container Rodent trapping

Center for Food Security and Public Health Iowa State University Prevent Entry Indoors Seal holes with steel wool or use sheet metal around foundation Clear away brush from foundation

Center for Food Security and Public Health Iowa State University Control Mice Outside Eliminate nesting sites − Elevate woodpiles and garbage cans Eliminate food sources − Store in tight containers − Cover uneaten food at night Encourage natural predators − Non-poisonous snakes, owls, hawks

Center for Food Security and Public Health Iowa State University Safely Clean Up Rodent Areas Wear rubber gloves Avoid sweeping or vacuuming initially Spray contaminated materials with disinfectant Seal dead rodents and excrement in bags and dispose Disinfect gloves before removal and Wash Hands !

Center for Food Security and Public Health Iowa State University Minimizing Outdoor Exposure Avoid contact with rodents Do not camp near rodent burrows Keep campsite clean Tightly seal all food Air out unused cabins before entering Avoid sleeping on the bare ground

Center for Food Security and Public Health Iowa State University Other Measures Use N-100 (HEPA) filters on respirators − Effective in removing virus particles less than 5 microns − Not tested in transmission of HPS

Center for Food Security and Public Health Iowa State University Internet Resources CDC All About Hantavirus − /phys/clinical.htm CDC Infectious Disease Pathology Activity − /printgenlsection.htm

Center for Food Security and Public Health Iowa State University Acknowledgments Development of this presentation was funded by a grant from the Centers for Disease Control and Prevention to the Center for Food Security and Public Health at Iowa State University.

Center for Food Security and Public Health Iowa State University Acknowledgments Author: Co-author: Reviewer: Radford Davis, DVM, MPH Danelle Bickett-Weddle, DVM, MPH Stacy Holzbauer, DVM