Herpes Viruses Herpes zoster Chickenpox Shingles Filename Herpes2.ppt

Herpes Zoster Outline Structure Classification Multiplication Clinical manifestations Epidemiology Diagnosis Control Baron’s Web Site

Varicellovirus genus in herpesvirus family human herpesvirus 3 (HHV3) varicella-zoster virus

Herpes Zoster virus

Chickenpox varicella

Varicella (chickenpox)

Varicella eruption

Varicella eruption

Chickenpox vesicle

Tzanck cell Chickenpox vesicle

Chickenpox chicken pox is the acute primary disease shingles is the delayed recurrent form of the same disease begins as a disease of childhood aerosol from a child most common source virus enters nose or throat - airborne - very communicable. early viral multiplication in upper respiratory tract, no symptoms; not infectious.

Chickenpox Incubation 10-20 days virus begins to disseminate during the latter part of the incubation period. virus enters regional lymph nodes. Passes into the blood and internal organs. patient becomes infectious 3-4 days before the first pox is seen. Sore throat is common 1-2 days before the first pox.

Chickenpox pox appears 14-21 days after the exposure. Usually, a macular i.e. flat rash appears on the skin. within 24 hrs. the vesicles appear and these form into pustules which form scab and fall off in a few days. virus is shed from the respiratory tract and the pox. virus sequestered in neural ganglia and remains latent.

varicella in adults can be life threatening varicella in adults can be life threatening. In pregnancy it can cause fetal infection and congenital varicella syndrome.

Chickenpox: Diagnosis clinical appearance antibody titres

Chickenpox Treatment usually is not treated. Acyclovir is used to treat disseminated infection in immunocompromised patients. ointments are used to relieve itching and bacterial infection of the lesions.

prevention and control living attenuated vaccine is available for immunocompetent children at high risk.

Shingles

Shingles disease of adults. greater than 65% are >45 yrs. reactivation can occur at any age and immunocompromised persons are high risk.

Herpes zoster

Herpes zoster

Shingles Herpes zoster

ZIG - Zoster Immune Globulin The antibodies are obtained from persons who have recently recovered from shingles.

Shingles Diagnosis fluorescent antibody for viral gene products. tissue cultures are used for rapid diagnosis. cells are grown for 24 to 72 hours. scrapings of lesions can also be diagnosed with very specific fluorescent antibodies. women have dysuria, urinary retention (involvement of urethra). 10% of individuals develop aseptic meningitis.

Sacral radiculomyelitis results in neuralgias, urinary retention, obstipation (intractable constipation). radiculitis is inflammation of the spinal nerve roots. radiculomyelitis is inflammation of the nerve roots and spinal cord. sacrum; the bones of the lower back.