Does Stress Really Impair Memory?

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Presentation transcript:

Does Stress Really Impair Memory? Student’s Name：顏嘉賢 School Number：B9802033

QUESTION How is stress related to memory? Enhance? Impair? Why?

INFORMATION 1: ENHANCEMENT OF MEMORY Stressful / emotionally arousing events enhance the “consolidation” of memory Stress hormones stress-activated neurotransmitters Amygdala

INFORMATION 2: STRESS HORMONES Glucocorticoids Cortisol Stress cortisol receptor Long-term exposure to cortisol atrophy of hippocampus naturally (In hippocampus)

Dendritic Spine Learning & memory Synapses

synapse

INFORMATION 3: CRH &CRHR CRH: corticotropin releasing hormone Secreted by hypothalamus CRHR: CRH receptor Located in hippocampus

Acute Stress CRH release hippocampus dendritic spines disintegration CRHR impair memory storage “consolidation” collection

BLOCK damage eliminated On the contrary… CRH CRHR BLOCK damage eliminated binding

INFORAMTION 4: REVERSIBILITY From Newcomer’s experiment: Memory impairment is reversible “the point of no return” Controlling cortisol levels pharmacologically

THE SAME QUESTION How is stress related to memory? Enhance? Impair?

THE ANSWER~~~~~ BOTH !!!! However…

CONCLUSION Stress itself is not harmful… but the EXCESS of stress is!!! Acute or chronic exposure to stress causes functional and morphological alterations in the brain impair memory consolidation

Thanks for your attention!

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