RESPIT™ Regionally-specific immunotherapy Standardized allergen extracts defined by geographic region Inclusion based on – Aerobiology – Allergenicity – Cross-reactivity RESPIT Regions

Background evidence There is no consensus as to the most accurate testing technique, which display significant variability and in some cases poor reliability Varied testing techniques and immunotherapy protocols produce similar results Studies support the role of non-specific tolerance in humans A double-blinded study found that stock mixture IT produced the same benefit as customized IT

Garfield, R. Injection Immunotherapy in the Treatment of Canine Atopic Dermatitis: Comparison of 3 Hyposensitization Protocols. 1992, Members Meeting of the AAVD & ACVD, p Customized vs. Standardized Immunotherapy for Canine Atopic Dermatitis

Comparison of standardized and allergen-specific IT Allergy test required Avoids false (-) and false (+) results RCT supporting effectiveness High-quality, placebo-controlled trials to establish efficacy Guides allergen avoidance Oral cavity & injectable administration available Standardized ASIT