Nervous System Lymphoma n Background u Hodgkin’s disease F Rarely involves the nervous system u Non-Hodgkin’s lymphoma F Involves nervous system in 10%

Slides:

Advertisements

Similar presentations

MOTOR NEURON DISEASE The motor neuron diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurons.

Advertisements

Z.Vaseie MD Emergency Medicine Resident Guillain Barre Syndrom (GBS)  Group of autoimmune conditions involving demyelination and acute axonal degeneration.

HAEMATOLOGY MODULE: LYMPHOMA Adult Medical-Surgical Nursing.

Spinal Cord Compression By: Sharon Sanders, Stacy Webb, Tonya Miller, Adrianne Rice & Lynn Davenport.

Acute Peripheral Weakness Peter Shearer, MD Assistant Residency Director Mt. Sinai School of Medicine.

Clinical Aspects of Peripheral Nerve and Muscle Disease Roy Weller Clinical Neurosciences University of Southampton School of Medicine.

Johns Hopkins University School of Medicine Clinico-Pathological Conference Benjamin M. Greenberg, M.D., M.H.S. Assistant Professor Department of Neurology.

11-1 Nervous Tissue I: Functional Organization, Spinal Cord and Spinal Nerves Lecture 12.

Disorders of peripheral nerves. Symptoms and signs of disorders of nerves Caused by changes in axons –Increased conduction time –Increased temporal dispersion.

Lecturer of Medical-Surgical

SPINAL TUMORS. GROUP MEMBERS:  Carlwyn Collins  Jennifer Haynes  Satrupa Devi Singh  Vanessa Wickham.

O THER MALIGNANT LYMPHOPROLIFERATIVE DISORDERS The lymphomas and plasma cell problems.

Essentials of Anatomy and Physiology Fifth edition Seeley, Stephens and Tate Slide 2.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin.

The Nervous System Medical Biology Mission Hills High School.

Aseptic meningitis  definition: When the CSF culture was negative.  CSF: pressure mmh2o: normal or slightly elevated. leukocytes : PMN early mononuclear.

SENSORY LESION By Prof. ASHRAF HUSAIN. Sensory Pathway Lesions.

Peripheral neuropathy is the term for damage to nerves of the peripheral nervous system.nervesperipheral nervous system.

Disorders of the Peripheral Nervous System Presented By: Joseph S. Ferezy, D.C.

SPINAL NERVE ROOT COMPRESSION AND PERIPHERAL NERVE DISORDERS Group A – AHD Dr. Gary Greenberg.

This lecture was conducted during the Nephrology Unit Grand Ground by a Sub-intern under Nephrology Division, Department of Medicine in King Saud University.

48-year-old man with ascending sensory deficits Teaching NeuroImages Neurology Resident and Fellow Section © 2014 American Academy of Neurology.

Multiple Sclerosis Alan Chen 4/1/14. General Information Other names: disseminated sclerosis or encephalomyelitis disseminata Inflammatory disease that.

Sagittal FLAIR images - Stable nonenhancing hyperintensities within the pericallosal white matter and bilateral centrum semiovale, consistent with known.

5.1b. Post-contrast Coronal T1 Wtd MRI5.1a. Post-contrast Axial T1 Wtd MRI A 52 year-old male with corpus callosal tumor. Q1. Diagnosis Please.

Teaching NeuroImages A Woman with Atypical Facial Pain Neurology Resident and Fellow Section.

The Nervous System Intro Qs: pg Structures of the nervous system: 1.List the structures that make up the nervous system. 2.What is a nerve? 3.What.

Brain Biopsy Frozen Section/Touch Prep. Brain Biopsy for Suspected Neoplasm Is it Abnormal? Is it Neoplastic? What Type of Neoplasm is it? What is the.

Combine conference NS 張維傑 / Chief CC Shen.

A 50 year old man with progressive tetraparesis and blindness Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology.

The Central Nervous System Poudre High School By: Ben Kirk.

Sponge: Set up Cornell Notes on pg. 15 Topic: 11.1 Meninges Essential Question: 1. NO EQ 2.1 Atoms, Ions, and Molecules 11.1 Meninges BRING BOOKS TOMORROW!!!!!

2011 AANP Diagnostic Slide Session Case 1 Janna Neltner, MD Dianne Wilson, MD Peter T. Nelson, MD PhD Craig Horbinski, MD PhD University of Kentucky.

Group A – AHD Dr. Gary Greenberg

Department of Neurology, The 2nd affiliated hospital, kunming Medical College Yinfengqiong.

47-year-old with progressive upper limb weakness Teaching NeuroImages Neurology Resident and Fellow Section © 2014 American Academy of Neurology.

The Peripheral Nervous System. Peripheral Nervous System 31 pairs of spinal nerves 12 pairs of cranial nerves All of the smaller nerves that branch from.

Peripheral Neuropathy Clinical Management Course February 12, 2007

THE PERIPHERAL AND AUTONOMIC NERVOUS SYSTEM Chapter 9.

Peripheral Nervous System 1: The Somatic System. Dichotomies 1. Tissues: neurons vs. glia 2. Position: CNS vs. PNS 3. Function 1: sensory vs. motor 4.

Peripheral Neuropathy : describes disorders of peripheral nerves, including the dorsal or ventral nerve roots; dorsal root ganglia; brachial or lumbosacral.

CT Scan and MRI spinal imaging findings in Spontaneous Intracranial Hypotension: a case report Sérgio Cardoso Radiology Department - Hospitais Cuf Lisbon,

Peripheral Nervous System (PNS). PNS  Cranial nerves (12 pairs)  Spinal Nerves (31 pairs)

Spinal Cord and Nerves.  Adult spinal cord is 18 inches long and 14 mm wide  Spinal cord does not continue in length with the vertebrae; stops at L1.

CNS & PNS Nerves, pathways. CNS –Brain, spinal cord –Processing center –Nuclei PNS –Spinal and cranial nerves –Information relay system –ganglia.

Localising the lesion – where in the nervous system?

DR. ZAHOOR ALI SHAIKH LECTURE First We Will Discuss ‘ORGANIZATION & CELLS OF NERVOUS SYSTEM’ then we will talk about ‘Overview of Central nervous.

Short Case Presentation Dr. Sania Khalid. Background Young female developed quadriplegia over a year Bed-ridden for 2 months Loss of bowel and bladder.

Peripheral nerve disease Peripheral nerve disease.

SPINAL CORD TUMORS Dr.Ghavam Tavallaee Neurosurgeon.

EPIDURAL CAVERNOUS HEMANGIOMA OF THE SPINAL CORD. CASE REPORT AND REVIEW OF THE LITERATURE. Petrosyan T, Zisakis A, Markogiannakis G, Hadjigeorgiou GF,

陳京瑜.  Inflammatory  Infectious  Hereditary  Acquired metabolic and toxic  Traumatic  Tumor.

Peripheral nerve disorders: A practical overview Praveen Dayalu, MD Clinical Associate Professor Department of Neurology University of Michigan.

Structure of the Nervous System Divided into two parts ◦ Central nervous system (CNS) ◦ Peripheral nervous system (PNS)

CLINICAL DIAGNOSIS OF CERVICAL DISORDERS Andradi S. Department of Neurology, University of Indonesia, Jakarta.

Multiple Sclerosis. Multiple sclerosis (MS) is a disease that affects central nervous system (brain and spinal cord). It damages the myelin sheath. 

Asymptomatic lymphadenopathy Mediastinal mass Systemic symptoms Fever, Pruritus Other nonspecific symptoms and paraneoplastic syndromes Intra-abdominal.

HS 200: Diseases of the Human Body Dr. Allan Ayella Unit 8a Seminar Chapter 13 and 14.

Introduction to Neuroanatomy and Terminology. Main Regions of the Nervous System Two Main Divisions –Central Nervous System –Peripheral Nervous System.

ACUTE FLACCID PARALYSIS Dr Shreedhar Paudel May, 2009

Principles and Practice of Radiation Therapy

THE PERIPHERAL AND AUTONOMIC NERVOUS SYSTEM

Uremic neuropathy 신장내과 R2 장준용.

THE PERIPHERAL AND AUTONOMIC NERVOUS SYSTEM

Peripheral Neuropathy

Guillain-Barre´ Syndrome

Morning Report 3/15/18 Kathryn Rimmer

FAB Classification of ALL

Harika Yalamanchili PGY-3

Neurology Resident and Fellow Section

PEREHHRAL NERVOUS SYSTEM

Presentation transcript:

Nervous System Lymphoma n Background u Hodgkin’s disease F Rarely involves the nervous system u Non-Hodgkin’s lymphoma F Involves nervous system in 10% of cases F Less differentiated, diffuse forms and bone marrow involvement increase risk of nervous system spread F Leptomeninges (6-8% of cases) F Epidural space (5% of cases)

Neurolymphomatosis n Background u Marek F Disease of Orpington roosters “Peripheral nerves infiltrated by lymphocytes”“Peripheral nerves infiltrated by lymphocytes” u Lhermitte and Trelles F “human peripheral neurolymphomatosis” u Diaz-Arrastia F Reviewed literature on 39 cases

Neurolymphomatosis n Background u Rare complication of NHL u At least 50% occur in context of systemic NHL u Most cases are associated with leptomeningeal involvement u Infiltration of spinal nerve roots, dorsal root ganglia and peripheral nerves

Neurolymphomatosis n Clinical features u Diaz-Arrastia- 39 cases F Neurology 1992; 42: u History F Subacute course over weeks most common F Acute/rapid course in ~10% of cases F Pain is common F Ante-mortem diagnosis in 35% of cases

Neurolymphomatosis n Clinical Syndrome u Examination F Lower motor neuron syndrome Weakness, sensory loss, areflexiaWeakness, sensory loss, areflexia F Other Cranial neuropathy (18)Cranial neuropathy (18) Bladder or bowel incontinence (10)Bladder or bowel incontinence (10) Ataxia (7)Ataxia (7) Mental changes (5)Mental changes (5)

Neurolymphomatosis n Diagnostic tests u CSF F Increased protein (73%) F Lymphocytic pleocytosis (70%) F Positive cytopathology (4/7 assessed) u Electrophysiology F Sensorimotor axonal neuropathy- most common F Mixed axonal/demyelinating neuropathy

Neurolymphomatosis u Neuroimaging F Thick, enhancing nerve roots, nerves u Nerve biopsy F Axonal degeneration F Demyelinating F Mixed

Neurolymphomatosis n Treatment u Concomitant involvement of subarachnoid space in 2/3 cases at autopsy- need drugs which penetrate blood brain barrier u Anecdotal F Surgery/Biopsy F Radiation F Chemotherapy Systemic plus/minus intrathecalSystemic plus/minus intrathecal

Nervous System Lymphoma n Background u CNS Lymphoma (Primary or Secondary) F Brain Most are primaryMost are primary F Leptomeningeal Most are secondaryMost are secondary F Spinal Cord Most secondary, from epidural compressionMost secondary, from epidural compression F Cranial nerve F Intravascular

Nervous System Lymphoma n Background u PNS Lymphoma F Nerve root F Plexus F Peripheral Nerve u CNS + PNS F Neurolymphomatosis Relevant to our case reportRelevant to our case report “Symptoms and signs of peripheral neuropathy that are confirmed by histopathologic evidence of lymphomatous infiltration of the nerves as seen by nerve biopsy or autopsy”“Symptoms and signs of peripheral neuropathy that are confirmed by histopathologic evidence of lymphomatous infiltration of the nerves as seen by nerve biopsy or autopsy”

Neurolymphomatosis

n Differential Diagnosis u Mononeuropathies (nerves, roots, plexuses) F Compression (tumor, vertebral collapse, hematoma) F Pressure palsies (loss of subcutaneous tissue) F Radiation F Herpes zoster F Brachial neuritis

Neurolymphomatosis n Differential Diagnosis u Polyradiculoneuropathies F Paraneoplastic (sensory, motor, both) F Guillain-Barre Syndrome F Chemotherapy (Vinca alkaloids) F Nutritional F Herpes zoster F Amyloid