Lecture 14/15 – Inflamation & Stress Signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F.

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Lecture 14/15 – Inflamation & Stress Signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Inflamatory responses Inflammatory responses The innate immune system is our first line of defense against invading pathogens. Initiates a vigorous and rapid inflammatory response to attack foreign pathogens Plays a key role in activating the more slowly developing adaptive immune response. o Activation of specific B and T cells to extend the host defense system Innate response is carried out by a complex series of cellular interactions, collectively known as the inflammatory response. Cellular players in the innate immune response/inflamatory response are: o Blood platelets o Macrophages o Mast cells o Neutrophils o Endothelial cells

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Inflamation

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Platelet Structure & Thrombus formation Module 11: Platelet Structure & Thrombus formation (A) (B)

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11 Figure platelet activation Module 11 Figure platelet activation

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Endothelial Cell Permeability Module 11: Endothelial Cell Permeability

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Cell Proliferation Platlet-derived growth factor – PDGF Transforming growth factor  (TGF-  ) Angiogenesis Vascular endothelial growth factor (VEGF)

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Cell Proliferation Platlet-derived growth factor – PDGF Transforming growth factor  (TGF-  ) Angiogenesis Vascular endothelial growth factor (VEGF)

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Sphingomyellin Signaling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Formation and Action of PAMPs

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 2: Toll Receptor Signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 2: Virus Recognition

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 1: Cytokines

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: TNFα apoptotic signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Apoptosis

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Figure Bcl-2 family functions

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 2: NF-κB activation

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Macrophage Signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Mast Cell Signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge Module 11: Cell Proliferation