U.S. Neurostimulation Markets Leveraging CRM Technology for Treating Neurological Conditions “Until recently, the only modes of treatment for many neurological conditions were drug therapy, invasive surgery, or, in some cases, behavioral or lifestyle changes. These two current entrenched therapies are the primary competition to the adoption of neurostimulation. Neurostimulation is reversible, programmable, localized, and testable providing it with significant advantages over drugs and traditional surgeries.” Medical Devices Group Analyst Team Frost & Sullivan

Limited awareness among physicians and patients about neurostimulation as additional treatment option restricts market penetration Ineffective transfer of research breakthroughs made in functional electrical stimulation to commercialization limits market development in many application areas DBS/VNS may hold potential for treating neuropsychological conditions but major hurdles regarding clinical research and market development limit commercial potential Rapidly expanding indications for neurostimulation drives market revenues Growing population of older Americans suffering from conditions indicated for neurostimulation increases market potential Clinical benefits of neurostimulation compared to surgery and drug regimens helps boost market revenues Industry Trends

Frost & Sullivan provides: Detailed insights into recent developments and trends Drivers, restraints, challenges, and strategic recommendations Analyst insights on ‘hot topics” and emerging applications in the Conferencing Market Market sizing and competitive analysis Market forecasts and opportunity analysis Detailed pricing breakdown of spinal cord stimulators, the largest market in neurostimulation Coverage of development-stage companies poised to enter the market Key Features

Coverage of United States market, home to the most important advances in the neurostimulation market Structured analysis tool to weigh which applications in the market have the greatest market potential Proven methodology encompassing extensive primary and secondary data and research Focused information and strategies that cover business and technology issues Credible data and analysis highlighting industry dynamics Winning strategies to help you create precise business plans What We Offer

Current Market Participants Accurate third-party assessment of market for use in business planning Assess current and future drivers and restraints Determine and exploit new application opportunities Identify development stage companies New Entrants Analyze challenges associated with the industry Learn about winning strategies used by existing competitors Position yourself to capitalize on the market’s unmet needs Third-party market estimations for use in business plans Investment Community Analyze long-term strategies of neurostimulation companies Determine which participants will outperform the competition Assess attractiveness of investing in market Who Will Benefit?

 Spinal Cord Stimulation for Chronic Pain  Deep Brain Stimulation for Essential Tremor and Parkinson’s Disease  Vagus Nerve Stimulation for Epilepsy  Sacral Nerve Stimulation for Urinary Dysfunction  Gastric Electrical Stimulation for Gastroparesis  Coverage of New Emerging Applications for Treating Depression, Anxiety, Alzheimer’s Disease, Obesity, and Other Disorders What’s Included

Advanced Bionics Corp. Cochlear Corp. Advanced Neuromodulation Systems, Inc. Cyberonics, Inc. Medtronic Neurological and Diabetes/ Medtronic, Inc. Micronet Medical NDI Medical, Inc. NeuroControl Corp. NeuroPace, Inc. Transneuronix, Inc. Key Market Participants

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