Case-Based Teaching Didactic Component: Subarachnoid Hemorrhage Department of Neurology University of Miami School of Medicine

Subarachnoid Hemorrhage Learning Objectives Describe the clinical presentation of a pt with SAH Describe the diagnostic evaluation of a pt with suspected SAH List the 6 major complications of aneurysmal SAH and describe their inpatient management

Clinical Presentation Aneurysmal subarachnoid hemorrhage –first, worst, different, or persistent headache –meningeal signs –signs of intracranial hypertension Also be aware of: 1) CN 3 palsies w/ PCOM aneurysms & 2) “sentinel bleeds”

Correlation of Lesion Localization & Clinical Findings Meninges –neck stiffness (AP direction) & pain –photophobia Intracranial hypertension –headache –nausea, vomiting –subhyaloid (preretinal) hemorrhage (associated with sudden  ICP) –lethargy (bicerebral dysfunction) Subhyaloid hemorrhages appear round when the patient is supine and crescent shaped (like a “U”) when the patient is upright.

Hunt & Hess Scale Choose the single most-appropriate grade Grade I: asx; mild HA; slight nuchal rigidity Grade II: moderate-to-severe HA; nuchal rigidity; no neuro deficit other than CN palsy Grade III:drowsiness/confusion; mild focal deficit Grade IV:stupor; moderate-to-severe hemiparesis Grade V:coma; decerebrate posturing Prognostic value in SAH pts: Grades I-III better prognosis & surgical candidates

Differential Diagnosis of Patient with Signs of Intracranial Hypertension +/- Meningeal Signs Subarachnoid hemorrhage –aneurysm, AVM, tumor –bleeding diathesis, anticoagulant Intracerebral hemorrhage –esp. caudate w/ IVH or midline cerebellum Subdural hematoma Meningitis

Evaluation CT scan of brain w/o contrast –if CT nondiagnostic: perform lumbar puncture cells 1st & last tubes (but may take 4-12 h for RBCs to reach lumbar cistern) xanthochromia (occurs 4 h to 2 wks after bleed) –if CT shows SAH: perform 4-vessel cerebral arteriography

CT Brain SAH in interhemispheric fissure & Sylvian fissures. Prominent interhemispheric SAH is characteristic of anterior communicating artery aneurysms. Blood in inter- hemispheric fissure Blood in Sylvian fissures

4-Vessel Cerebral Arteriography 7-mm anterior communicating artery aneurysm (straight black arrow) smaller incidental L MCA aneurysm also seen (curved black arrow) AP view of LICA angiogram ACAs LMCA LICA

Aneurysmal SAH: Common Locations of Cerebral Aneurysms

Management Consult neurosurgeon immediately for aneurysmal clipping to eliminate rebleeding risk Begin monitoring &/or treating major complications of aneurysmal SAH –Rebleeding—esp. 1 st hrs, resolves w/ clipping –Vasospasm—days 4-14, nimodipine + triple-H therapy –Seizures—prophylactic fosphenytoin/phenytoin –Hyponatremia—due to central salt-wasting syndrome; give NS –Hydrocephalus—after 1-2 wks, ventriculostomy –Cardiac arrhythmias/MI (non-Q wave)—monitor in unit

Management NOTE: The most important thing to monitor is the patient’s LOC, since most SAH complications affect it –Rebleeding –Vasospasm (= delayed cerebral ischemia) –Seizures –Hyponatremia –Hydrocephalus

Management: Therapy begun preop, continued postop Supportive care –dark, quiet room in ICU; HOB > 30 degrees –ECG monitoring, frequent neuro checks –stool softener, antiemetic, narcotic, sedative –IV NS, H-2 blocker (not cimetidine), SCDs –fosphenytoin/phenytoin

Management: Delayed Cerebral Ischemia (DCI) of Vasospasm Nimodipine 60 mg q4h po (x 21 d) begun preop –Do not use a higher dose (if BP too low, DCI worse) Monitor w/ TCD at least daily –treat  d velocities, even before signs or sxs Start with triple-H therapy in this order: 1. Hypervolume: IV NS 150 cc/h 2. Hyperosmolarity: albumin 5% 250 cc IV q4h 3. Hypertension: dopamine (monitor CVP or PAWP) Angioplasty if triple-H therapy fails

CT Scan: Consequences of Delayed Cerebral Ischemia CT scan of bilateral ACA infarcts (dark areas) due to vasospasm in pt with ruptured anterior communicating artery aneurysm Note blood in the Sylvian and interhemispheric fissures

Counseling Recurrence not likely with clipped aneurysm Resume previous activities when able Likely safest not to undergo MRI in the future Cigarette smoking increases risk of SAH Familial condition more likely if: –polycystic kidney disease in pt or family –more than two relatives have cerebral aneurysm Asymptomatic aneurysms > 7 mm have increased risk of rupture

The End Department of Neurology University of Miami School of Medicine