Toxicology “The science of poisons” Catalina Marambio Jones Major lesson 3, May 30 th.

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Presentation transcript:

Toxicology “The science of poisons” Catalina Marambio Jones Major lesson 3, May 30 th

Toxicology research Paracelsus ( ) "All things are poison, and nothing is without poison; only the dose permits something not to be poisonous.“ Orfila ( ), father of the toxicology

Death of Socrates, painted by Jacques Louis David (1787)

Hemlock (Conium maculatum) coniine 100 mg can be fatal 6-8 fresh leaves or even less amount of seeds and roots

"The Death of Cleopatra," painted in 1892 by Reginald Arthur

Egyptian cobra (Naja haje) Injects mg of venom in one bite. Stops nerve signals Respiratory failure in 10 min.

The Borgias in the italian Renaissance

“The Cantarella poison” Arsenic, copper, and phosphorus. Cantharidin Blistering agent and chemical burns. As little as 10 mg is potentially fatal.

TCDD poisoning

Chemical and biological warfare World war I World war II, Approximately 4 million people were murderer in gas chambers. Iran-Iraq war Genocide against the Kurdish people, approximately 5000 people were killed.

Toxicology in the news

Accidental poisoning in the news

"Toxicology is the study of the adverse physicochemical effects of chemical, physical or biological agents on living organisms and the ecosystem, including the prevention and amelioration of such adverse effects."

Risk assessment Reference:

First: what is the potential to cause harm ? Reference:

Second: are we in contact with the hazard?, how much? Reference:

Third: Connecting hazard and exposure Reference:

Fourth: Calculating the risk Reference:

Hazard

Hazard but no exposure Reference:

Hazard and exposure Reference:

Dose response curve

How much is too much? -Dose response A bit of shark…….

A bit more……… How much is too much? -Dose response

Now you are playing with your luck…. How much is too much? -Dose response

Going over the threshold…… How much is too much? -Dose response

Finally a response!!!! How much is too much? -Dose response Reference:

Think-pair share 1. What is more toxic?

Think-pair share 2. What is the therapeutic index?

Experimental part Record: concentration and number of shrimp alive after exposure.

Questions? See you tomorrow!