What is Evidence-Based Medicine?. Today I put forward an idea Tomorrow I doubt it The day after I refute it And each day I can be wrong’ Voltaire 1745.

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Presentation transcript:

What is Evidence-Based Medicine?

Today I put forward an idea Tomorrow I doubt it The day after I refute it And each day I can be wrong’ Voltaire 1745

Volume of new information a major barrier 5,000? per day 1,360 per day 55 per day

The Problem The Knowledge Gap Time to meet information needs decreasing Amount of Information is rising Knowledge Gap Time Amount of Information

Half-time or Half-life of Clinical Medical Science is now about 6 Month

Doubling time of biomedical science was about 19 years in 1991

about 20 months in 2001 Doubling time of biomedical science was

So you work in a job which: Its half-time (half-life) is 6 months, & Its doubling-time is 20 month You works in a ever-changing & ever- growing profession ! So you should keep updating !

The Slippery Slope Years since Med School graduation Knowledge of best current HTN care Shin,et al: CMAJ;1993:

For General Physicians to keep current: Read 19 new articles per day which appear in medical journals 19 x 2 hrs (Critical Appraisal) = 38 hrs per day Davidoff F et al. (1995) EBM; A new journal to help doctors identify the information they need. BMJ 310:

"Kill as Few Patients as Possible" - Oscar London Rule 31- Review the world literature fortnightly A Year of MEDLINE indexed journals Washington Monument 555 feet

Can’t I trust the editors? Percent of articles meeting quality criteria NEJM 12.6% Ann Int Med 7.6% JAMA 7.2% Lancet 6.2% BMJ 4.4% Arch Int Med 2.4%

Medical Publishing Annually: 20,000 journals 17,000 new books MEDLINE: 4,000 journals 6 Million references 400,000 new entries yearly

Types of Medical articles Original Article Review Article Case Reports

Hierarchy of studies

EBM History G. Guyatt from McMaster University in 90s Sackett in 1995 defined EBM  “Our clinical decesion malking should be based on the best scientific avaiabe evidence”

What is Evidence? Evidence is anything used to determine or demonstrate the truth of an assertion. Scientific evidence is evidence which serves to either support or counter a scientific theory or hypothesis. In scientific research evidence is accumulated through observations of phenomena occur in the natural world, or created as experiments in a laboratory

What is ‘level of evidence’? The extent to which one can be confident that an estimate of effect or association is correct (unbiased).

Levels of Evidence Level of Evidence Type of Study 1a Systematic reviews of randomized clinical trials (RCTs) 1b Individual RCTs 2a Systematic reviews of cohort studies 2b Individual cohort studies and low-quality RCTs 3a Systematic reviews of case-controlled studies 3b Individual case-controlled studies 4 Case series and poor-quality cohort and case-control studies 5 Expert opinion based on clinical experience Adapted from: Sackett DL et al. Evidence-Based Medicine: How to Practice and Teach EBM. 2nd ed. Churchill Livingstone; 2000.

Evidence Based Medicine D.J. Van Durme, MD EBM: Original “Official” Definition The explicit, conscientious, and judicious use of the current best evidence in making decisions about the care of individual patients (and populations) Evidence-Based Medicine Working Group Sackett et al circa 1996

What is EBM? The best research Clinical expertise Patient value

Better – EBM definition

EBM - What is it? Clinical Expertise Research Evidence Patient Preferences

Traditional medicine Experiences Pathophysiology, references, … Patient value

By best research evidence clinically relevant research Unbiased research Reproducible research often from the basic sciences of medicine especially from patient centered clinical research

By clinical expertise We mean the ability to use our clinical skills and past experience to rapidly identify each patient’s unique health state and diagnosis, their individual risks and benefits of potential interventions, and their personal values and expectations.

By patient values We mean the unique preferences, concerns and expectations each patient brings to a clinical encounter and which must be integrated into clinical decisions if they are to serve the patient.

When these three elements are integrated, clinicians and patients form a diagnostic and therapeutic alliance which optimizes clinical outcomes and quality of life

Lu-Yao: JAMA, Volume 269(20). May 26, 1993.

EBM Steps 1. Ask your clinical question 2. Search your literature for answer 3. Appraise the retrieved documents 4. Apply your findings 5. Evaluate the performance

The five-step process for using an evidence- based approach in general practice (1) define the problem (2) track down the information sources you need (3) critically appraise the information (4) apply the information with your patients (5) evaluate how effective this application of information is.

A cquire the best evidence A ppraise the evidence A pply evidence to patient care A ssess your patient A sk clinical questions EBM Method

What are the limitations of EBM? First, the need to develop new skills in searching and critical appraisal can be daunting, although (as we pointed out above) evidence-based care can still be applied if only the former has been mastered and directed toward pre- appraised resources

Second, busy clinicians have limited time to master and apply these new skills, and the resources required for instant access to evidence are often woefully inadequate in clinical settings. Finally, evidence that EBM “works” has been late and slow to come.

The usefulness of EBM 1. Treatments & diganistic test are being used at a time when their effectiveness is approved 2. EBM prevent using ineffective tratment methods, so it will probabaly decrease charges

The usefulness of EBM 3. It help us updateing our knowledge continously instead of reading lots of irrleavany & unreliabae litraure, so time saving. 4. It helps policy makesrs through development of clinical guidlines, providing them with enough documntsm& evidence

The usefulness of EBM 5. Instead of teaching students current standard treatment method, it teach them how to find the best current therapy for their disease 6. EBM promote evidence instead of persons authority 7. It decreases medical errors

Seven alternatives to evidence based medicine Eminence based medicine Vehemence based medicine Eloquence based medicine Providence based medicine Nervousness based medicine Diffidence based medicine Confidence based medicine

Eminence based medicine The eminent physician's white hair and balding pate are called the "halo" effect. The more senior the colleague, the less importance he or she placed on the need for anything as mundane as evidence. Experience, it seems, is worth any amount of evidence.

Vehemence based medicine The substitution of volume for evidence is an effective technique for brow beating your more timorous colleagues and for convincing relatives of your ability.

Eloquence based medicine The year round suntan, carnation in the button hole, silk tie, Armani suit, and tongue should all be equally smooth. Sartorial elegance and verbal eloquence are powerful substitutes for evidence.

Providence based medicine If the caring practitioner has no idea of what to do next, the decision may be best left in the hands of the Almighty. Too many clinicians, unfortunately, are unable to resist giving God a hand with the decision making.

Nervousness based medicine Fear of litigation is a powerful stimulus to overinvestigation and overtreatment. In an atmosphere of litigation phobia, the only bad test is the test you didn't think of ordering.

Diffidence based medicine Some doctors see a problem and look for an answer. Others merely see a problem. The diffident doctor may do nothing from a sense of despair. This, of course, may be better than doing something merely because it hurts the doctor's pride to do nothing.

Confidence based medicine This is restricted to surgeons

Was it clear enough !