Lab This Week: EKGs and Blood Pressure Bring textbook Bring calculator Wear clothes and shoes for running stairs Easy access to wrist and ankles for ECG electrodes Easy access to arms for Blood Pressure measurement Wear Wofford logo if you wanna be in Olencki pics

Revising Abstracts Instructions forthcoming. Due date to be announced. Keep all papers together for resubmission!

For Friday Quiz Be prepared to draw and label electrocardiograms for – Normal – 1 st degree heart block – 2 nd degree heart block Be able to diagnose from an ECG – Atrial fibrillation – Ventricular fibrillation – Premature ventricular systole – 3 rd degree heart block

1QQ#26 for 10:30 a)Catecholamines acting on beta-adrenergic receptors cause arteriolar smooth muscles to relax. b)Vasopressin is a vasoconstrictor. c)Of the several modes of exchange in capillaries, diffusion is the most important for the delivery of nutrients and removal of wastes. d)There are five Starling forces. e)For bulk flow, water and colloids move through aqueous channels and intracellular clefts. e) Was not graded. I intended the term to be intercellular clefts and I didn’t do a good job of making a distinction.

1QQ#26 for 11:30 a)Catecholamines acting on alpha-adrenergic receptors cause arteriolar smooth muscles to relax. b)Endothelin-1 is a vasoconstrictor. c)Of the several modes of exchange in capillaries, bulk flow is the most important for the delivery of nutrients and removal of wastes. d)There are only three Starling forces. e)During bulk flow in capillaries, water and crystalloids move through aqueous channels and intracellular clefts. e) Was not graded. I intended the term to be intercellular clefts and I didn’t do a good job of making a distinction.

Figure Main difference in the Pulmonary circuit? Net filtration = 4L/day Bulk Flow through aqueous channels and intracellular clefts Regulated by arterioles Starling Forces S 10

Bulk Flow and Starling Forces

Who Cares? Aunt Esther Cancer of the liver; Failure of hepatocytes to produce plasma colloids S 12

Pc ∏c Aunt Ester

Actions of Histamine and antihistamines Pc ∏c Hypotension

Fig PcPc PcPc PcPc S 11

Figure Crystalloids Colloids Bulk Flow S 13

Figure Liver & Bone Marrow & Spleen Fate of 4 L/d excess filtrate S 1 Mode of propulsion?

Filariasis in Haiti: Washington Post Article

Figure Veins are Capacitance vessels (high compliance) with valves for unidirectional flow Arteries are low compliance, so any increase in volume increases pressure. S 2

Fig MAP = CO x TPR Negative feedback control: stimulus, receptors, afferent pathway(s), integrator, efferent pathway(s), effector(s) response(s) S 3

Fig S 4 What happens to the set point for MAP during exercise?

Story Time A Neuroscientist in New Orleans S 5

MAP = CO x TPR Mean Arterial Pressure = Cardiac Output x Total Peripheral Resistance MAP = (HR x SV) x TPR S 2 Creating your Hemorrhage Diagram Loss of 1 liter of blood from vein → ↓ blood volume → ↓ MAP → …..

Beginning with a loss of about 1 liter of blood from a vein, diagram the early events associated with hemorrhage and the negative feedback responses to hemorrhage in a well-organized diagram. Write legibly! Completeness, accuracy, and detail, together with the proper sequence earn maximal points. The following abbreviations can be used: AI, AII, JGA, mAChR, Hct, Q, SV, EF, RBC, HR, EDV, ACh, ANH, ADH, CO, TPR, EPO, VR, MAP, EPI, NE, SAN, aAdR, bAdR, Symp (sympathetic), Parasymp (parasympathetic), PV, r (radius), Pc, fAP (frequency of action potentials.) Any other abbreviations must be defined. "If in doubt, write it out!" Use single headed arrows (→) to indicate sequential relationships and doubled-stemmed arrows to indicate increases or decreases.