Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado.

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Presentation transcript:

Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

NORMAL ANATOMY

SAGITAL SECTION OF THE PROSTATE GLAND Seminal Vesicle Central Zone Bladder Peri-urethral zone Anterior Zone Fibro-muscular Peripheral Zone Transition Zone Urethra

3D VIEW OF THE PROSTATE

CROSS SECTION OF THE PROSTATE FIBROMUSCULAR STROMA anterior PERI-URETHRAL STROMA EJACULATORY DUCTS

TRANZITIONAL ZONE Seminal Vesicle Urethra

CENTRAL ZONE

Peripheral Zone

Fibro-muscular Stroma anterior

HISTOLOGY

Bad Histology

Peripheral Zone

Central Zone

40X Seminal Vesicles

20X Seminal Vesicles

20X

Paraganglion

Neurons40X

Benign Lesions

Inflammation

Acute Inflammation

Granuloma

20X Corpora Amylacea

20X Calcified

200XCristalloid

200X Stromal Nodules

H Y P E R P L A S I A

PRIMARY NODULAR HYPERPLASIA

Cell Type Mesenchymal Fibroblast Smooth Muscle Basal Cells Secretory Cells Special PatternsUsual Patterns Predominantly stromal Predominantly glandular Mixed Small Cell Hyperplasia Leiomatous Hyperplasia Basal Cell Hyperplasia Crybiform Hyperplasia BENIGN NODULAR HYPERPLASIA

BPH & Inflammation

BASAL CELL HYPERPLASIA

200X

BASAL CELL HYPERPLASIA

BASAL CELL HYPERPLASIA - HMWCK

ATROPHY

20X SIMPLE ATROPHY

200X ATROPHY

40X ATROPHY

10X CYSTIC ATROPHY

PIN Prostatic Intraepithelial Neoplasia

Secretory cells Lumen Basal Cells Basal Membrane Normal Dysplasia Carcinoma MildModerate Severe In situ Microinvasive Low GradeHigh Grade Prostatic Intra-epithelial Neoplasia Prostatic Intraepithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

It continues in Part 2