5.1b. Post-contrast Coronal T1 Wtd MRI5.1a. Post-contrast Axial T1 Wtd MRI A 52 year-old male with corpus callosal tumor. Q1. Diagnosis Please.

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5.1b. Post-contrast Coronal T1 Wtd MRI5.1a. Post-contrast Axial T1 Wtd MRI A 52 year-old male with corpus callosal tumor. Q1. Diagnosis Please

5.2. Post-contrast Coronal T1 Wtd MRI A 60 year-old male with known hemopoetic systemic disease. Q2. Diagnosis Please

5.3. Post-contrast Axial T1 Wtd MRI A 35 year-old female with multiple cranial nerve neuropathy. Q3. Diagnosis Please

5.1a. Post-contrast Axial T1 Wtd MRI5.2. Post-contrast Coronal T1 Wtd MRI5.3. Post-contrast Axial T1 Wtd MRI Figures 5.1 – 5.3 are produced by a hemopoetic tumor. Diagnosis: ?

5.1a. Post-contrast Axial T1 Wtd MRI5.2. Post-contrast Coronal T1 Wtd MRI5.3. Post-contrast Axial T1 Wtd MRI Figures 5.1 – 5.3 are produced by a hemopoetic tumor. Diagnosis: Lymphoma

5.1b. Post-contrast Coronal T1 Wtd MRI5.1a. Post-contrast Axial T1 Wtd MRI Figure 5.1. Homogeneously enhancing tumor is seen involving the splenium of the corpus callosum (arrows) spreading across the midline. Diagnosis: Primary Lymphoma of the brain

5.2. Post-contrast Coronal T1 Wtd MRI Figure 5.2. Diagnosis: Secondary Lymphoma with calvarial involvement (green arrow) and associated epidural tumor (yellow arrows) / scalp tumor (red arrow)

5.3. Post-contrast Axial T1 Wtd MRI Figure 5.3. Linear enhancement of the cerebellar sulci (yellow arrows) and left temporal sulci (red arrow). Diagnosis: Secondary Lymphoma with subarachnoid tumor seeding (arrows).

Central Nervous System Lymphoma Primary lymphoma of the brain is rare, accounts for less than 3.5% of primary brain tumors. Non-Hodgkin’s Lymphoma, usually B-cell lymphoma. Can be seen in patients with AIDS. Tumor intensely enhances with contrast. Common sites of involvement include: Basal ganglia/thalamus Corpus Callosum Periventricular white matter Lymphoma responds well to chemo-radiation therapy. Open or stereotactic biopsy is necessary to establish the diagnosis. Complete surgical resection of the tumor is not necessary as they respond well to chemo-radiation therapy