毒物分析授課教師：賴滄海教授 03-28-2008 LC-MS of drugs of abuse and related compounds.

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毒物分析授課教師：賴滄海教授 LC-MS of drugs of abuse and related compounds

Rapid Commun. Mass Spectrom.2005;19: Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching

Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography-mass spectrometry journal of Chromatography B, 814 (2005)

Doping substances  Diuretics Narcotics  β 2 -Blockers Cannabis  Steroids HCG Erythropoietin  Stimulants HGH Insulin, HBOC

 Figure 9.1 Diuretics with thiazide structure are converted by hydrolysis or sulphoxidation during sample transportation, storage or preparation, which may cause analytical problems in GC-MS. Respective artefacts need to be factored into LC-MS screening