The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

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Presentation transcript:

The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, (2000) Speed Amplitude Spatio-temporal pattern

Spatial aspects of Ca 2+ signalling Nature 395, (1998)

Basic Mechanisms of Ca 2+ Signalling

Elements of the Ca 2+ signalling toolkit Nature Rev. Mol. Cell Biol. 1, (2000)

quarks/sparks blips/puffs

[IP 3 ] and lumenal Ca 2+ modulate the shape of the bell-shaped curve Current Biology 1999, 9:R876-R878

The steps leading to activation or inactivation of IP 3 receptors Current Biology 1999, 9:R876-R878

Ca 2+ signalling by conformational coupling using macromolecular complexes Nature Rev. Mol. Cell Biol. 1, (2000)  1s

Application of the Ca 2+ signalling toolkit to regulate different cellular processes Nature Rev. Mol. Cell Biol. 1, (2000)

The spatial organization of Ca 2+ release from internal stores Nature Rev. Mol. Cell Biol. 1, (2000)

Schematic representation of the mitochondrial Ca 2+ transport pathways in energized mitochondria

3-D imaging of mitochondrial and ER structure in living HeLa cells M ER

Structural Organization of the Endoplasmic Reticulum in Neurons Neuron, 21, 13–26, (1998)

Binary Membrane System of Neural Calcium Signaling Neuron, 21, 13–26, (1998)

Proposed Role of Ca 2+ Signaling in Neuronal Gene Transcription Neuron, 21, 13–26, (1998)

Compartmentalization of Ca 2+ signals in neurons Nature 395, (1998)

A Ca 2+ nexus — crosstalk between signalling pathways L-VDCC IP 3 R Nature Rev. Mol. Cell Biol. 1, (2000)

Schematic structures and sequences of cameleons Nature (1997) 388,

Nature Reviews Neuroscience (2002) 3,

Immobilization and superfusion of CaM kinase II Science 279, (1998)

Properties of immobilized CaM kinase II Science 279, (1998)

Stimulation of CaM kinase II by pulse flow Science 279, (1998)

Modulation of the frequency response of CaM kinase II Science 279, (1998)

Calcium rollercoaster Science 279, (1998)