Amlodipine -Calcium Channel Blocker- 15.06.05 목희연

Amlodipine 화학명 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester 분류 고혈압 치료제 (dihydropyridine 계열) 약리 Calcium Channel Blocker 적응증 고혈압 상품명 Norvasc 개발회사 Pfizer

Calcium Channel Blocking Drugs ∙Three Classes of CCBDs Chemical Type Chemical Names Brand Names Phenylalkylamines Verapamil Calan, Isoptin Benzothiazepines Diltiazem Cardizem 1,4-Dihydropyridines Nifedipine Nicardipine Isradipine Felodipine Amlodipine Adalat, Procardia Cardene DynaCirc Plendil Norvasac Verapamil

Calcium Channel Blocking Drugs ∙Three Classes of CCBDs Chemical Type Chemical Names Brand Names Phenylalkylamines Verapamil Calan, Isoptin Benzothiazepines Diltiazem Cardizem 1,4-Dihydropyridines Nifedipine Nicardipine Isradipine Felodipine Amlodipine Adalat, Procardia Cardene DynaCirc Plendil Norvasac Diltiazem

Calcium Channel Blocking Drugs ∙Three Classes of CCBDs Chemical Type Chemical Names Brand Names Phenylalkylamines Verapamil Calan, Isoptin Benzothiazepines Diltiazem Cardizem 1,4-Dihydropyridines Nifedipine Nicardipine Isradipine Felodipine Amlodipine Adalat, Procardia Cardene DynaCirc Plendil Norvasac Amlodipine

Calcium channel

Voltage-gated Calcium channel Type Most often found in L-type calcium channel ("Long-Lasting" AKA "DHP Receptor") 골격근, 평활근, 심장근육 P-type calcium channel ("Purkinje") /Q-type calcium channel 푸르키니에 섬유 N-type calcium channel ("Neural"/"Non-L") 뇌 신경 R-type calcium channel ("Residual") 소뇌 과립세포 T-type calcium channel ("Transient") 신경세포, 심장근육

Calcium binding mechanism

Calcium channel Blocking 혈관확장, 동방결절 전기 신호 억제

Effects of CCBDs 혈관확장 심장수축저해 동방결절억제 방실결절억제 1,4-Dihydropyridines Benzothiazepines Phenylalkylamines 혈관 선택성 Ca2+ 길항작용 : 1,4-Dihydropyridines 심장 선택성 Ca2+ 길항작용 : Phenylalkylamines, Benzothiazepines

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