DDICC Overview: biomedical and healthCAre Data Discovery Index Ecosystem Lucila Ohno-Machado, MD, PhD UCSD Biomedical Informatics NIH BD2K Joint Kick-off Meeting Rockville, MD, Nov 3-4, 2014

 Aims  Task Forces  Pilot Project $ Call for Collaborators to Work on Pilot Projects Yearly RFA for New Pilots  Administrative Supplements  Organization 2

Aims 1. Help users find accessible data By disease, data modality, demographics, etc. 2. Assist data producers on how to publish data for maximal discoverability Assess of impact of disseminated data 1. Train data producers and data users Tools related to biomedical data sharing PubMed of Data = DataMed 3

Steering Committee Chair: Ohno-Machado NIH: Ian Fore, Jennie Larkin, Ron Margolis Dawei Lin, Alison Yao (program officers) Task Force and Community Engagement leaders Taskforce 1: Data Shop UT Houston: Xu Pilot Projects Ontologies and Standards Taskforce 2: Data Showcase U Michigan: Alter Pilot Projects Visualization and User Needs Taskforce 3: Data Market Oxford U: Sansone Pilot Projects Incentives and Publishing Supplements Collaborating PIs NIH-funded projects Data and Expert Knowledge Management UCSD: Mahera (general) Farcas (technical) Community Engagement UCSD: Martone

Data Shop Linking Data to the Literature Ontology- Based Discovery Tools Data Showcase Meeting User Needs Intelligent Search and Visualization Data Market Publishing for Reuse Citation Networks and Incentives 12 3 Task Forces

Administrative Supplements 6 COHEN, TREVOR UNIVERSITY OF TEXAS HOUSTON Using Biomedical Knowledge to Identify Plausible Signals for Pharmacovigillance KLEINSTEIN, STEVEN H. YALE UNIVERSITY Computational Tools for the Analysis of High-throughput Immunoglobulin Sequencing WAGER, TOR D. UNIVERSITY OF COLORADO fMRI-based Biomarkers for Multiple Components of Pain WINSLOW, RAIMOND L JOHNS HOPKINS UNIVERSITY The Cardiovascular Research Grid LIU, HONGFANG MAYO CLINIC NLP for Clinical and Translational Research MATTINGLY, CAROLYN J NORTH CAROLINA STATE UNIVERSITY Generation of a Centralized and Integrated Resource for Exposure Data O'MALLEY, BERT W BAYLOR COLLEGE OF MEDICINE A Hub for the Nuclear Receptor Signaling Atlas HRIPCSAK, GEORGE M. COLUMBIA UNIVERSITY Discovering and Applying Knowledge in Clinical Databases

Data Shop Pilots Year 1  Linking Publications and Underlying Data Using NLP Hua Xu, UT Houston  Rating Relationship in Imaging Reports: Machine vs. Crowdsourcing Approaches Ricky Taira, UCLA 7

Data Showcase Pilots Year 1  Recommendation System: Machine Learning and Crowdsourcing Xiaoqian Jiang, UCSD  Intelligent Search and Visualization of Data Todd Johnson, UT Houston 8

Data Market Pilot Year 1  Citation and Data Access Metrics for a Molecular Data Bank and Related Resources Peter Rose, UCSD Chun-nan Hsu, UCSD 9

Timeline 10

11 Thank you! Questions?