Ultrasound Elastography: Prostate Cancer Detection Assessment Using A Phantom Brett Coelho Medical Biophysics 3970Z March 26, 2013

Introduction  Prevalence and Early Detection  Ultrasound Elastography  Specificity and Sensitivity B-mode Prostate Image

Introduction  Stiffness  Strain Images B- mode ImageStrain Image

Methods  Hooke’s Law  Young’s Modulus Reconstruction: Iterative

Methods  Phantom Construction Phantom Ingredients

Methods  Preparing Phantom Solutions  Gelatin – 70  Agar – 80  Formaldehyde – 90  Glycerol – 90  Sigma Cell  Cool Down

Methods  Pouring The Moulds Prostate and Surrounding Tissue MouldsTumor Moulds

Methods Pouring The Moulds Prostate and Sample Moulds

Methods  Uniaxial Test Uniaxial Testing Machine and Cylindrical Sample

Methods  Ultrasound Circular Ultrasound Array Linear Array

Methods  Strain Images Strain Imaging

Results  Uniaxial Results  Ratios Ep/Es=5.4  Et1/Es=8.7  Et2/Es = 9.3 Strain Stress kPaStress kPa

Results  Post Processing  Elastic Moduli Reconstruction Strain Image Frames

Results  Post Processing  Ep/Es=2.2  Et1/Es=6.0  Et2/Es=8.9 Phantom Tissue Manual Selections

Results  Tumour Mis Allocations  TM1=5.21  TM2=5.68 Reconstructed Image Tumor Locating B-mode Image Tumor Locating

Conclusions  Comparing the ratios  Tumor Misallocations

Sources of Error  Strain Images  Uniaxial Test  Assumptions for Stress Calculation

Future Research  Improve Detection and Modulus Calculations  Computational Time  Assumptions and Meshing

Acknowledgements  Dr. Samani  Reza Mousavi  Thank you!