中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Trends in the survival of patients with nasopharyngeal carcinoma in Sihui city, Guangdong province, P.R. of China: a population-based study Q ing Liu, Jinou Chen, Qihong Huang, Yanhua Li Cancer Center, Sun Yat-sen University Sihui Cancer Institute

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER NPC Epidemiological Charateristics in Sihui Incidence rate of NPC: 30.9 in male and 13.0 in female Mortality rate of NPC: 22.0 in male and 7.7 in female Incidence rates and mortality rates of NPC kept stable Comparing to the reduction in HK, TW, LA in USA

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Trend of NPC incidence in HK

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Trend of NPC incidence in Sihui

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Materials and methods Cancer registry system since 1973 in Sihui Follow up system for NPC cases since incidence cases of NPC were chose during Follow up to the end of 2006, Max follow up year= (70.3%) cases with pathological evidence

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Materials and methods Kaplan–Meier estimate for survival rates Cox proportional hazards regression for risk factor screening Risk factors: gender,age,period of diagnosis,clinical stage, pathological status,diagnosis medical unit were analyzed

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Materials and methods Relative survival probabilities for NPC were assessed by matched sex, age group, period of diagnosis with general population Age-specific death rates and life table of Sihui general population was available based on death registry system SURV3 was used for relative survival rate estimation SAS 9.2 for other statistical analyses

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Results

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Characteristics of patients with NPC Gender N % Male Female Age at diagnosis <

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Characteristics of patients with NPC Clinical stage N % I II III IV Unknown Pathological diagnosis WHO I WHO II/III Unknown

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Characteristics of patients with NPC Period diagnosed N % Diagnostic hospital CC Other

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Five year survival of NPC patients in Sihui MTS OS(95%CI) RS(95%CI) All cases ( )60.3( ) Gender Male ( )59.3( ) Female ( )62.2( ) Age at diagnosis < ( )59.4( ) ( )60.1( ) ( )62.5( ) ( )59.1( )

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Five year survival of NPC patients in Sihui MTS OS(95%CI) RS(95%CI) Clinical Stages I ( ) 85.2( ) II ( ) 69.4( ) III ( ) 44.7( ) IV ( ) 37.9( ) Unknown ( ) 64.4( ) Path WHO I ( )56.9( ) WHO II/III ( )62.3( ) Unknown ( )58.8( )

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Five year survival of NPC patients in Sihui MTS OS(95%CI) RS(95%CI) Period diagnosed ( ) 51.8( ) ( ) 51.1( ) ( ) 62.5( ) ( ) 84.8( ) Diagnostic Hospital CC ( ) 62.3( ) Others ( ) 56.9( )

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Risk factors related to death from NPC by Multivariate Cox Regression HR 95%CI GenderMale1.00 Female Age< StageI1.00 II III IV HistoWHOII/III1.00 WHO I Period

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Observed and relative survival (95%CI) of NPC in Sihui

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Relative survival of NPC, stage I and II

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Relative survival of NPC, stage III and IV

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER Conclusion Significant improvement of NPC survival No change of proportion of stage of NPC cases Improved radiotherapy might contribute to survival of NPC Screening for NPC will definitely increase survival of NPC May predict a reduction of mortality rates of NPC in Sihui

中山大学肿瘤防治中心 SUN YAT-SEN UNIVERSITY CANCER CENTER screening