Fochon Pharma “FOCHON” - Continuing Innovation/Creation F - Fluorine O - Oxygen C - Carbon H - Hydrogen O - Oxygen N - Nitrogen.

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Presentation transcript:

Fochon Pharma “FOCHON” - Continuing Innovation/Creation F - Fluorine O - Oxygen C - Carbon H - Hydrogen O - Oxygen N - Nitrogen

Fochon’s Mission “To discover and develop innovative and more effective therapies for diabetes and cancer, and to make a difference in people’s lives” 2Fochon Pharma, Inc

Fochon Utilizes Global Innovation to Maximize Drug Discovery Efficiency Fochon Pharma, Inc3 San Francisco Bay Area, US San Francisco Bay Area, US  Experienced scientific team  A network of drug discovery experts  Entrepreneur sprit & Biotech hub Chongqing & Shanghai, CN Chongqing & Shanghai, CN  Cost-effective talents and resources  Well established drug discovery & development infrastructures and development infrastructures and experiences experiences By fully take the advantage of the time differences between the two locations, Fochon discovers NMEs around the clock

Creation of Best-In-Class Drugs PhaseIPhaseIIPhaseIII Phase IV & Post & Post Marketing Surveillance Metabolism, Pharmacokinetics, Pharmacology & Toxicology Lead Discovery Preclinical Clinical Trials Medicinal Chemistry & Structure-Based Drug Design Discovery Clinical Development Such focus enables Fochon to undertake only projects with a high probability of success in the most capital & time-efficient manner Validated Drug Targets & Druggable Scaffolds Out-licensing/Partnering at IND stage Fochon Focuses on Lead Design & Optimization High Risk High $$$ Target identification & Validation Assay Devlop HTS & Hit-To- Lead 4Fochon Pharma, Inc

Structure-Based Design of DPP-4 Leads Fochon Pharma, Inc5 Superimposing ABT-341 (green) with MEK-0431(magenta) in DPP-4 binding site CF 3

Fochon's Strong Pipeline Mainly on Cancer and Diabetes Fochon Pharma, Inc6 Lead Optimization Fotagliptin (Anti-Diabetes) ALK Kinase (Anti-Cancer) (Anti-Cancer) Pan-Her Kinase (Anti-Cancer (Anti-Cancer) MEK Kinase (Anti-Cancer) Lead Expl. c-Met(Anti-Cancer) Preclinical Develop. IND China Phase I Lead Optimization Lead Expl. Preclinical Develop. IND China Phase I Lead Optimization Lead Expl. Preclinical Develop. IND China Phase I Lead Optimization Lead Expl. Preclinical Develop. IND China Phase I Lead Optimization Lead Expl. Preclinical Develop. IND China Phase I Lead Optimization Preclinical Develop. IND China Phase I EGFR/Her2(Anti-Cancer) PI-3K, BRAF etc. (Anti-Cancer) Lead Expl. Lead Optimization Preclinical Develop. IND China Phase I

Win-Win Collaboration SELLAS Fochon Pharma, Inc7  Add drug development capability to Fochon  Make the human talents and excellent research & development facilities in Greece and Europe available to Fochon  Similarly, Fochon will open up China & Asia’s resources to SELLAS  By maximizing the synergy between the two companies, we will build a strong pipeline & a powerhouse that competes in the global market  Benefit patients all around the world