EPIDEMIOLOGICAL AND CLINICAL FEATURES OF LIVER CIRRHOSIS Dolghii Xenia Dr. Melania Macarie Faculty of Medicine, UMPh Tîrgu Mureș Department of Gastroenterology I, Faculty of Medicine, UMPh Tîrgu Mureș

Introduction Cirrhosis is a liver disease defined by extensive fibrosis with regenerative nodule formation and distorsion of liver structure. It is an ireversible condition that also has serious complications including ascites, variceal hemorrhage,hepatic encephalopathy, hepatocellular carcinoma and hepatorenal syndrome. Alcohol abuse and viral infection are the worldwide most common causes of cirrhosis.

Aim The aim of this study is to establish the main epidemiological and clinical aspects of this disease in our geographical area.

Material and Method A retrospective study was performed which included patients with liver cirrhosis admitted in Gastroenterology department of Tîrgu Mureș Emergency County Hospital between 01.01.2013-31.12.2013. The readmissions were excluded. According to age the patients were stratified into 2 groups: under the age of 50 years old and the ones aged over 50 years old. Data were collected with Microsoft Excel program and analyzed with GraphPad InStat program. Categorical data analysis was conducted with Fisher Exact Test. <50 YEARS OLD >50 YEARS OLD

Results During the studied period 302 cirrhotic patients were admitted in the Gastroenterology division of Tîrgu Mureș Emergency County Hospital. There were included in the research 239 patients with a median age of 58.13 years old.

Demographical Data Total 239 patients <50 years old 49 patients Mean Age 58,13 42,20 62,27 Urban 111 21 90 Rural 128 28 100 Gender( M/F) 149/90 35/14 115/75

Distribution by gender Male prevalence of cirrhotic patients (M/F ratio of 1.65/1).

Distribution by gender and age Male prevalence of cirrhotic patients in “<50 years old”. (Ratio of 2.5/1).

Distribution by etiology Prevalence of toxic etiology (n=149 patients), followed by viral etiology (HCV) (n=65 patients) and HBV (n=23).

Distribution by etiology and age

Predominance of toxic etiology in “<50 years old” sample.

Other clinical data(I) Prevalence of Variceal bleeding among cirrhotic patients in “<50 years old ”vs “>50 years old” samples.

Other clinical data(II) Prevalence of hepatic encephalopathy among cirrhotic patients in “<50 years old ”vs “>50 years old” samples.

Conclusions Cirrhosis is a common end result of liver damage ( Mostly caused by alcohol and viral hepatitis) Cirrhosis is a frequently encountered disease even among the young population. Cirrhosis prevalently affects male population. In its terminal stages, cirrhosis is frequently associated with other diseases and may have fatal complications.

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