Pathophysiology Zhao Mingyao (Jasper) Department of Pathophysiology Medical College, Zhengzhou University

Top 10 China’s Universities for MBBS study with moderate tuition fees (Duration: 6 years, 2012 ) 16/72 (22.2%) UniversityTuition fee RMB( USD) per year UniversityTuition fee RMB( USD) per year 1. Central South UniversityCentral South University (5160) 6. Jiangsu UniversityJiangsu University (3500) 2. Zhengzhou University*****Zhengzhou University (4195) 7. Dalian Medical UniversityDalian Medical University (6774) 3. Southeast UniversitySoutheast University (4840) 8. Wuhan UniversityWuhan University (5160) 4. Huazhong University of Science and TechnologyHuazhong University of Science and Technology (6452) 9. Capital Medical UniversityCapital Medical University (5500) 5. Tianjin Medical UniversityTianjin Medical University (6620) 10. Xi ’ an Jiaotong UniversityXi ’ an Jiaotong University (6600) *****

about 5, 10, 20y later A true doctor could not find a position in society ? Consist of every day and every class In ZZU now Study hard for good future

How many attend class? Total

Data analyse 16/72 (22.2%) international students from ZZU passed Medical License Exams in India, failed In India, More than 6000 students from the world participated in the Medical License Exams in 2011 ， 800 passed it. 60 graduates from TMU attended the exams and 39 of them passed(65%). Among 800 passman, Mr. Aurabh Suman came second in the exams.

Home Home | About Us | RTI | Tenders| FAQ ’ s| DNB Vacancy|Application Status| Contact Us | Disclaimer | Sitemap About Us RTI Tenders FAQ ’ s DNB VacancyApplication Status Contact Us Disclaimer Sitemap Roll No NameGAURAV JOSHI CourseFMGE ResultPASS SessionSEPTEMER 2011 Date Of Birth30/07/88 Marks Obtained : 182 (Maximum Marks : 300) The above displayed results are for internet based information only. Result letters are sent to all candidates by post. Candidates may verify their results from signed copy of result placed at the reception office of the National Board of examinations, Ansari Nagar, New Delhi.

Run fast to get worm Run fast to get gold medal You pass Medical License Exams as soon as possible, can get ideal job earlier

How to do? I only hear; I forget I see, write down and repeat; I remember I do and think; I understand

1. What is Pathophysiology ？ 2. Why to study it ？ 3. How to study it ？ 4. What is it consisted of in our textbook? Preface to Pathophysiology

1.What is pathophysiology?

Pathophysiology ? = Clinical Physiology Medical Physiology Physiology of Disease Physiology of Disordered Function

Pathophysiology ? = abnormal physiology + abnormal biochemistry

Pathophysiology = Explore the rule of origin and evolution of disease processes (the underlying mechanisms). Basing on physiology and biochemistry

The Methodologies Used in Pathophysiology Experiments study Clinical observation Epidemiological study

? Basic medicine Clinical medicine 2. Why to study Pathophysiology ？ explain “ Why and How ” of diseases

Why Is Pathophysiology Important? An essential introduction to clinical medicine A bridge: basic medicine and diseases Enables us to understand why and how diseases develop Various clinical manifestations appear, which are the underlying mechanisms In so doing devise rational therapeutics

3. How to study pathophysiology ？ Success comes with industry, but diligence …?

Major Points in Learning Pathophysiology The general concepts The etiology and pathogenesis The alterations of metabolism and function The principles for prevention and therapies

4.Content of pathophysiology in this textbook Pathological process General introduction on disease Systemic and organic ~ Cellular and molecular ~

Conspectus of Disease Chapter 1

1.Concept of Disease Aberrant manifestation of deregulated homeostasis caused by harmful agents The development of a disease is a pathologic process with a characteristic set of signs and symptoms involved in the whole body or any of its parts

Concept of Health Without any evidence of disease, and a state of complete well-being physically, socially and psychologically WHO health disease subhealth transitiontransition stagestage

2.Etiology of Disease Study the causative agents Answer the question why disease happens

complete well-being physically socially psychologically Extrinsic FactorsIntrinsic Factors Predisposing factors Precipitating factors

3. Pathogenesis of diseases

General rules for pathogenesis of diseases (1) Disruption of homeostasis (2) Process of damage and anti-damage (3) Reversal role of cause and result (4) Correlation between systemic and local regulations furuncle

Eyewinker Monocyte Physic barrier Stress Immunoreaction Inflammation Coagulation Detoxification Radiation Microbe Stressor Pyrogen Teratologic Carcinogen Trauma Process of damage and anti-damage

 Neural regulations  Humoral regulations  Cellular regulations  Molecular regulations Basic Mechanisms for Disease

4.Phases of Diseases Latency Prodrome Recovery Disease 序曲 前奏 高潮 尾声 Clinic symptoms

Outcome of Disease Recovery Death Complete recovery Incomplete recovery

Death  The body as a whole stops working forever  Brain death is the marker for the diagnosis

Brain Death (WHO criteria) Cessation of spontaneous respiration Irreversible coma Absence of cephalic reflexes Dilated or fixed pupils Absence of any electrical activity of the brain Absence of brain blood flow

Significance for diagnosis of brain death  In favor of recording the time of death  Define the time to terminate for the rescue  In favor of organ transplantation

How to do? I only hear; I forget I see, write down and repeat; I remember I do and think; I understand

Thank you!