The pre-erythrocytic stage, when the parasite is in the hepatocytes MALARIA VACCINES.

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Presentation transcript:

The pre-erythrocytic stage, when the parasite is in the hepatocytes MALARIA VACCINES

Life Cycle Of Malaria The asexual stage, when the parasite binds and infects the erythrocytes. 

Finally the sexual stage, involves vaccines that elicit antibodies which prevent the development of the sexual stage within the midgut of the mosquito

MALARIA VACCINE DEVELOPMENT Pre-erythrocytic vaccines. R32Tox-A Trial:An average efficiency of 70.9% against Plasmodium falciparum. Life Cycle Of Malaria 

Asexual stage vaccines Spf66 Trial: In Gambia; >5% effective in young children. Transmission blocking vaccines Pfs25 Life Cycle Of Malaria 

Multistage-multicomponent versus Single stage vaccines Spf66 NYVAC- Pf7 Trial: Efficiency of 2.8% against Plasmodium falciparum. Trial 1: In Colombia it gave an efficiency of 33% over all ages and 77.2% over ages < 5 years. Trial 2: In Gambia it gave an efficiency of 8% in 6-11 month babies and 9% over ages 2-15 years.

Occurrence of malaria

Anti-malarial drugs Quinine (antipyretic drug) extracted from the bark of the cinchona tree. Chloroquine (less toxic than Quinine) Prophylaxis; Mefloquine & Halofantrine. Artemisinin (orally administered) Deoxycycline.