CPC #5 Pathology. CD3 CD20 Ki-67 Diagnosis Intravascular Large B-Cell Lymphoma.

Slides:

Advertisements

Similar presentations

Hepatocirrhosis Liver cirrhosis.

Advertisements

Non-Hodgkin’s Lymphoma

Non Hodgkin’s lymphoma

FDG-PET in Aggressive Lymphoma Chen Shih-Wei, SKH.

Find out more on:  NETs is the umbrella term for a group of unusual, often slow-growing cancers, which develop from cells in.

HAEMATOLOGY MODULE: LYMPHOMA Adult Medical-Surgical Nursing.

ACEP Clinical Policy: Adult Headache Patients. Ponte Vedra Beach, FL June 24, Clinical Decision Making in Emergency Medicine Ponte Vedra Beach,

By the end of this session you should know:

Non-Hodgkin Lymphoma Showing Abnormalities of c-myc Including Dual Translocations Involving c-myc and Bcl-2: A Clinicopathologic Study R Jastania, V Kukreti,

Radiation Injury Can Mimic Tumor Progression Following Proton Radiotherapy for Atypical Teratoid Rhabdoid Tumor in Pediatric Patients M Chang 1, F Perez.

Chronic Lymphocytic Leukemia (CLL) DEFINITION CLL is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid.

Chapter 17 Chronic Leukemias.

Chronic Lymphocytic Leukemia. Definition Clonal B cell malignancy. Progressive accumulation of long lived mature lymphocytes. Increase in anti-apoptotic.

M. BENDARI, M. Rachid, S. Marouane, A. Quessar, S. Benchekroun Department of Hematology-Oncology pediatric Hospital 20 Aout, CHU Ibn Rochd Casablanca.

Hematopoietic Stem Cell Transplantation: High Risk Diffuse Large Cell Lymphoma: Ginna G. Laport, MD Associate Professor of Medicine Division of Blood &

Breast Cancer By George Rezk.

Non-Hodgkin’s lymphomas-definition and epidemiology

CNS Neoplasm Dr. Raid Jastania, FRCPC Assistant Professor, Faculty of Medicine, Umm Alqura University Vice Dean, Faculty of Dentistry.

Long-term Follow-up of Aortic Intramural Hematomas and Penetrating Ulcers Alan S. Chou, BA, Bulat A. Ziganshin, MD, Paris Charilaou, MD, Maryann Tranquilli,

Extranodal Lymphoma: Waldeyer’s Ring Lymphomas, primary Muscle Lymphoma Sinus Lymphomas , Bone.

Lymphoma. ALLMMCLLLymphomas Hematopoietic stem cell Neutrophils Eosinophils Basophils Monocytes Platelets Red cells Myeloid progenitor Myeloproliferative.

O THER MALIGNANT LYMPHOPROLIFERATIVE DISORDERS The lymphomas and plasma cell problems.

GASTRIC LYMPHOMAS Aswad H. Al.Obeidy FICMS, FICMS GE&Hep Kirkuk General Hospital.

Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City,

Incidence of Childhood Cancer. What is cancer ? Uncontrolled growth of cells Are these cancer cells abnormal? No, but their behaviour is.

Hodgkin’s Lymphoma By: Tonya Weir and Paige Mathias Date: October 13, 2010.

CPC #2: 38 year old woman with HIV/AIDS and altered mental status October 9, 2007.

MANAGEMENT OF MANTLE CELL LYMPHOMA IN TUNISIA R BEN LAKHAL, L KAMMOUN, K ZAHRA, S KEFI Sousse 25 MAY 2012.

Introduction to Pathophysiology. Definitions Pathophysiology-the physiology of abnormal states; specifically the functional changes that accompany a particular.

T-cell/histiocyte-rich large B cell lymphoma Monirath Hav, MD, PhD fellow Pathology Department Ghent University Hospital.

Brain Biopsy Frozen Section/Touch Prep. Brain Biopsy for Suspected Neoplasm Is it Abnormal? Is it Neoplastic? What Type of Neoplasm is it? What is the.

HERPES SIMPLEX ENCEPHALITIS ENCEPHALITIS M.RASOOLINEJAD, MD DEPARTMENT OF INFECTIOUS DISEASE TEHRAN UNIVERCITY OF MEDICAL SCIENCE.

NOT ALL SWELLING WITH REDNESS AND BAD SMELLY DISACHRGE IS NECESSARLY AN ABSCESS Al-Sharabati, Mohamed Barakat, MD, Pathologist Rasheed, Osaid, RN, CNS.

Stash Fera Mutations Technical Biology Mr. Bouchette

NHL13: A Multicenter, Randomized Phase III Study of Rituximab as Maintenance Treatment versus Observation Alone in Patients with Aggressive B ‐ Cell Lymphoma.

Felice Giangaspero BIOPATOLOGIA DEI LINFOMI PRIMITIVI CEREBRALI Mediterranean School of Oncology Burning questions on lymphoproliferative diseases Rieti.

Sequential Dose-Dense R-CHOP Followed by ICE Consolidation (MSKCC Protocol ) without Radiotherapy for Patients with Primary Mediastinal Large B Cell.

Myeloproliferative Disorders (MPDs)

Quize of the week Hajer AlZuhair Medical resident.

Dose-Adjusted EPOCH plus Rituximab in Untreated Patients with Poor Prognosis Large B-Cell Lymphoma, with Analysis of Germinal Center and Activated B-Cell.

Blood Cancers in older adults Cancer and Older Adults 19 November 2015 Matthew Foster, MD Assistant Professor of Medicine Leukemia, Lymphoma and Myeloma.

Corinne Haioun et al. Survival benefit of high dose therapy in poor risk aggressive non Hodgkin’s lymphoma: final analysis of the prospective LNH87-2 protcol-

Lymphoma Rob Jones. Aim and learning outcomes Aim ◦ To revise the key points of lymphoma Learning outcomes ◦ Revise the basics of haemopoiesis ◦ Understand.

APPROACH TO LYMPHOID MALIGNANCIES. Patient Evaluation of ALL Careful history and PE CBC Chemistry studies Bone marrow biopsy Lumbar puncture.

Osteomyelitis By: Chloe and Mikala. What is Osteomyelitis?  An infection of the bone, a rare but serious condition  Infection in one part of the body.

Hematopoetic Cancers. Hematopoesis Leukemia New diagnoses each year in the US: 40, 800 Adults 3,500 Children 21,840 died of leukemia in 2010.

Chapter 11 Lymphatic System Disorders Mitzy D. Flores, MSN, RN.

HANDOUT 3 RARITIES.

Helicobacter pylori and Gastric Lymphoma

Case 255 Elizabeth Courville, MD Robert Hasserjian, MD Massachusetts General Hospital Society for Hematopathology/European Association for Haematopathology.

Society for Hematopathology/ European Association for Haematopathology 2013 Workshop Case 145 Nidhi Aggarwal, M.D.; Robert L. Redner, MD; Fiona E. Craig,

Treatment of non-Hodgkin Lymphomas

Blood 2011, 117: R1 Seon-Hye Kim Arnaud Jaccarda and Olivier Hermine Journal conference.

Randomized phase III study on the effect of early intensification of rituximab in combination with 2-weekly CHOP chemotherapy followed by rituximab or.

Case 9 A 55 year old male presented with an enlarged axillary lymph node. Staging identified multiple enlarged lymph nodes, and B symptoms, including night.

NON-HODGKIN’S LYMPHOMA

Non-Hodgkin’s Lymphoma

KIDWAI MEMORIAL INSTITUTE OF ONCOLOGY, BANGALORE

Improved survival in primary central nervous system lymphoma up to age 70: a population-based study on incidence, primary treatment and survival in the.

Case Presentation Intern 郭彥麟.

Oncology for Family Medicine Residents:

PRIMARY CUTANEOUS γδ T-CELL LYMPHOMA:REPORT OF A RARE ENTITY

Frozen Section/Touch Prep

Treatment of a Frail Older Patient with Diffuse Large B-Cell Lymphoma on Maintenance Dialysis: Attenuated Immunochemotherapy and Adapted Care Plan Case.

بسم الله الرحمن الرحيم "وفي أنفسكم أفلا تبصرون" صدق الله العظيم

Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma.

Introduction to Pathophysiology

Neurology Resident and Fellow Section

Foroud shahbazi Pharm.D

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

Presentation transcript:

CPC #5 Pathology

CD3

CD20

Ki-67

Diagnosis Intravascular Large B-Cell Lymphoma

Intravascular Large B Cell Lymphoma Extranodal Diffuse Large B Cell Lymphoma characterized by lymphoma cells confined to lumen of small vessels Affects adults Symptoms arise from occlusion of capillaries Absence of homing recptors on neoplastic cells –CD29 (B1-integrin) –CD54 (ICAM-1)

Intravascular Lymphoma: Presentation Skin-plaques and nodules CNS-dementia, focal neurologic deficits –DDX: Vasculitis Fever of Unknown Origin

Intravascular Lymphoma: Prognosis Thought to have poor prognosis –Delay in diagnosis –Poor response to chemotherapy –Cutaneous-only cases (almost always females) may be a better prognosis DiGiuseppe JA, Nelson WG, Seifter E, Boitnott JK, Mann RB. J Clin Oncol 1994;12: –Aggressive combination chemotherapy can yield long term survival

Follow-Up on This Case On 12/29/2008 the patient was transferred to begin chemotherapy for intravascular lymphoma. CHOP therapy was initiated and her altered mental status resolved rather quickly. As of 10/20/2009 the patient is status post 6 cycles of R- CHOP, the last being in 05/09. Her course has been complicated by a sacral decubitus ulcer with associated osteomyelitis for which she was treated with 6 course of vancomycin and cefepime which was completed on 09/10/09. She also has indwelling foley catheter with chronic contamination of C-candida glabrata.