Section 3: CKD, CVD and mortality. Cardiovascular diseases in CKD patients Damage to the heart (Uraemic cardiomyopathy ) Damage to the arteries (Uraemic.

Slides:



Advertisements
Similar presentations
Essentials of CKD Comorbidities and outcomes in CKD.
Advertisements

Cardiovascular Disease In CKD: Is It for Children
Lysaght, J Am Soc Nephrol, 2002 Number of patients worldwide treated with chronic dialysis from 1990 to ,000 1,490,000 2,500,000.
Chronic kidney disease: [insert title here] Insert name, title, date here Insert acknowledgements here.
CKD in individuals with CKD
ESAs and Outcomes in CKD Patients Philip Lui PharmD The 13th Annual Contemporary Therapeutic Issues in Cardiovascular Disease May 8, 2010.
Chapter 2: Healthy People A NNUAL D ATA R EPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE.
Chapter 4: Cardiovascular Disease in Patients With CKD 2014 A NNUAL D ATA R EPORT V OLUME 1: C HRONIC K IDNEY D ISEASE.
Etiology Primary hypertension 95% of all cases Secondary hypertension – 5% of all cases – Chronic renal disease – most common White coat hypertension –
Welch Center Uniting Medicine & Public Health Prevalence of Albuminuria, and its Relationship to Decreased GFR and Outcomes Josef Coresh, MD, PhD Director,
Chapter 6: Medicare Expenditures for CKD 2014 A NNUAL D ATA R EPORT V OLUME 1: C HRONIC K IDNEY D ISEASE.
Chapter 2: Identification and Care of Patients With CKD 2014 ANNUAL DATA REPORT VOLUME 1: CHRONIC KIDNEY DISEASE.
Lesley Stevens MD Tufts-New England Medical Center
Reference Cooper BA, and the IDEAL study group. A randomized controlled trial of early versus late initiation of dialysis. N Engl J Med [Accessed.
Prevalance of Chronic Kidney Disease 26 million people have diagnosed chronic kidney 26 million people have diagnosed chronic kidney disease (CKD) ( National.
Chapter 3: Morbidity & Mortality 2014 ANNUAL DATA REPORT VOLUME 1: CHRONIC KIDNEY DISEASE.
Section 1: CKD Epidemiology. The Problem Chronic Kidney Disease is an epidemic worldwide –Growth 6-8% per annum of dialysis patients Accumulating data.
Estimated GFR Based on Creatinine and Cystatin C
Section 4: Managing progression of CKD. Glomerulosclerosis Reduction in number of functioning glomeruli Increased blood flow to remaining nephrons Intraglomerular.
6 / 5 / RENAL DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED INTO 3 GROUPS BY BASELINE GLOMERULAR FILTRATION RATE (GFR) ALLHAT.
SM Gatmiri, MD, Nephrologist Imam Khomeini Hospital,
Cardiovascular Disease in Women Module I: Epidemiology.
Kreatinine Verklaard !? Introductie. At what level of creatinine does a 65-year-old diabetic, hypertensive white woman weighing 50 kilograms have chronic.
Cardiovascular Risk In Chronic Kidney Disease Dr Ginny Quan.
THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND RENAL FUNCTION. WHAT'S THE ROLE OF INFLAMMATION? Marquis Hawkins, Ph.D. Postdoctoral Scholar University.
The management of renal problems in primary care Hugh Gallagher Consultant Nephrologist St Helier Hospital.
Section 2: Detection of CKD. What Tests Are Available? Direct GFR measurement –Inulin clearance –Radionuclides –Iohexol clearance 3 hr CrCl with Cimetidine.
Epidemiology of Anaemia in CKD
Community Outreach to Reduce Disparities in Cardiovascular & Diabetes Morbidity & Mortality in the South Bronx Michael Alderman, MD Michelle Johnson, MD,
2015 ANNUAL DATA REPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE Chapter 6: Mortality.
Chapter 2: Identification and Care of Patients With CKD 2015 A NNUAL D ATA R EPORT V OLUME 1: C HRONIC K IDNEY D ISEASE.
2015 ANNUAL DATA REPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE Chapter 7: Transplantation.
2015 ANNUAL DATA REPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE Chapter 9: Cardiovascular Disease in Patients With ESRD.
ALLHAT 6/5/ CARDIOVASCULAR DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED BY BASELINE GLOMERULAR FILTRATION RATE (3 GROUPS by GFR)
Chapter 6: Medicare Expenditures for Persons with CKD 2015 A NNUAL D ATA R EPORT V OLUME 1: C HRONIC K IDNEY D ISEASE.
2015 ANNUAL DATA REPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE Chapter 5: Hospitalization.
2015 ANNUAL DATA REPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE Chapter 2: Healthy People 2020.
6/5/ CARDIOVASCULAR DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED BY BASELINE GLOMERULAR FILTRATION RATE (4 GROUPS by GFR) ALLHAT.
1 به نام خدا. Epidemiology of chronic kidney disease 2.
Matthew R. Weir, MD Professor and Director Division of Nephrology University of Maryland School of Medicine Baltimore, Maryland Kidney Disease and Dialysis.
The SYMPHONY Trial Reference Reddan DN, et al. Renal function, concomitant medication use and outcomes following acute coronary syndromes. Nephrol Dial.
Am J Kidney Dis. 2014;63(6): R3 박세정 /prof. 이태원 Comparative Effectiveness of Early Versus Conventional Timing of Dialysis Initiation in Advanced.
Association of Chronic Kidney Disease With the Spectrum of Ankle Brachial Index The CHS (Cardiovascular Health Study) Joachim H. Ix, MD, MAS,*†§ Ronit.
Date of download: 7/1/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Scope of Coronary Heart Disease in Patients With.
The FAVORIT Study (Folic Acid for Vascular Outcome Reduction in Transplantation) Source Bostom AG, Carpenter MA, Kusek JW, et al. Homocysteine-lowering.
National service framework for Renal
Section 4: Managing progression of CKD
2016 Annual Data Report, Vol 2, ESRD, Ch 6
Incidence and Risk of Cardiac Events in Patients With Previously Treated Multiple Myeloma Versus Matched Patients Without Multiple Myeloma: An Observational,
Diabetic Cardiovascular Disease Predicts Chronic Kidney Disease Awareness in the Kidney Early Evaluation Program Cardiorenal Med 2011;1:45–52 - DOI: /
Section 3: CKD, CVD and mortality
Volume 1: Chronic Kidney Disease Chapter 3: Morbidity and Mortality
The MDRD Study.
Effect of Obesity on In-Hospital Mortality in Patients with Cardiogenic Shock Complicating AMI Obesity is paradoxically associated with favorable mortality.
Introduction: Alarming Statistics Causes of Death in Prevalent Dialysis Patients,
SAVE: Risk of total mortality associated with reduced kidney function
Chapter 6: CKD among Children and Adolescents
2016 Annual Data Report, Vol 1, CKD, Ch 3
Incidence and Risk of Cardiac Events in Patients With Previously Treated Multiple Myeloma Versus Matched Patients Without Multiple Myeloma: An Observational,
Mean eGFR among survivors after CABG surgery vs all-cause deaths
Chapter 3: Morbidity and Mortality
Rounded incidence values (%) of renal and nonrenal events
SIGNIFY Trial design: Participants with stable coronary artery disease without clinical heart failure and resting heart rate >70 bpm were randomized to.
The US Renal Data System “Pie Chart of Death”
American Journal of Kidney Diseases
Age-Standardized Rates of Death from Any Cause According to the Estimated GFR among 1,120,295 Ambulatory Adults Alan S.Go et al. N Engl J Med 2004; 351:
Baseline Characteristics of Elderly Participants in the Cardiovascular Health Study,According to Quintiles of Cystatin C Michael G.Shlipak et al N Engl.
Risk factors Odds ratio 95% CI p Age >75 (referent: age 46-60) 2.17
Risk differences for incident stroke, coronary heart disease (CHD), and cardiovascular mortality (per 1000 person-years) by clinical risk factor in the.
Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients Miyamoto et al. Am J Nephrol 2017;45:  
Presentation transcript:

Section 3: CKD, CVD and mortality

Cardiovascular diseases in CKD patients Damage to the heart (Uraemic cardiomyopathy ) Damage to the arteries (Uraemic arteriopathy)

Cardiovascular Mortality Annual mortality (%) 25–3445–5465–74  85 35–4455–6475–84 Male Female Black White Dialysis General population Age (years)

Synergistic effect of CKD, CHF and Anemia as risk factors for Death Collins, Adv studies in Med yr mortality (n~ 200,000 5% Medicare sample) %

Cardiovascular Mortality Rates are Higher among Dialysis Patients Adapted from Levey AS et al. Am J Kidney Dis 1998; 32: General population: male General population: female Dialysis: male Dialysis: female DOD/

CKD predicts CV events: HOPE study Mann et al. Ann Intern Med 2001;134:629–636 Creatinine <124 µmol/l Creatinine ≥ 124 µmol/l n=8307 n=908 Events per 1000 person years HOPE=Heart Outcomes and Prevention Evaluation study

Cause of death in dialysis patients

CKD Outcomes: Mortality and Dialysis StageGFR (ml/min)RRTDeath %19.5% %24.3% %45.7% 27,998 CKD patients followed for 5 years Keith DS, AIM 2004;164:

Prevalence of Co-morbidity and Level of GFR % GFR  60 ml/min GFR <60 ml/min DMCHFStroke/ TIA PVDAny CVD IHD