Course of Immunology - introduction (2015/2016) Marta Sobotková

Course structure ● Lectures -Presence in lectures is obligatory -Lectures are held every Tuesday at 8:00-9:40 - Three absences are tolerated, more frequent absences must be based on official certificate and will be solved individually

DateThemeTeacher Immune system, overview. Phagocytic cells, complement. Communication between cells of immune systems, adhesion molecules, cytokines. prof. Špíšek Antigen processing and presentation, HLA I and II class.prof. Šedivá Specific (adaptive) immunity T and B lymphocytesPharmDr.Palich - Fučíková Immunity against infectionAdkins Immunodeficiency, vaccinationprof.Šedivá Immunity against tumors.prof. Špíšek Immunology of transplatationdr. Kalina Autoimmunity. Immunopathology.dr. Sobotková Immunopathological reactions, allergydr. Kayserová Immunotherapydr. Podrazil Clinical aspects of immune disordersDr. Horváth

● Seminars - The first seminar and presentation of your thesis are compulsory; the time of other seminars is devoted to self-studying, preparation of seminar thesis and consultations with teachers Course structure

Seminar thesis ● groups of 1-3 students ● structure of thesis: – 2000 words -form of an essay -briefly & concisely & interestingly -Abstract, text and references (literature) are obligatory, subchapters and discussion are recommended ●Term of submission: until in the digital form (doc form preffered) - has to be sent to:

Regulatory T cells - function and subtypes IL-17, its role in pathologic inflammatory process Immune homeostasis in the gut and oral tollerance Biology of NKT cells Toll-like receptors and its function The role of B lymphocytes and antibodies in antitumor immunity Immunology of sepsis Immunology of coeliac disease. Pathogenesis of oedema in hereditary angioedema and targets for acute attack treatment Mechanisms of dysregulation in humoral immunodeficiences – CVID as model disease Presence and future od monoclonal antibodies in allergic diseases treatment The newest strategies of cancer immunotherapy. Seminar thesis

- November 18 and 25, time am. - each thesis will be presented verbally - range: 8 minutes - Powerpoint presentation (6-10 slides) Oral presentations

Final appraisal ● Presence on lectures ● Seminar thesis: fulfilled / not fulfilled + verbal appraisal (after presentation) ● Verbal examination: 2 out of 50 questions

Evaluation of the essay: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the essay Other comments: Evaluation of the verbal presentation: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the presentation

● shedules ● presentations (download possible) ● recommended literature, links ● contacts

Citation Literature / References: 2.DRISCOLL DA, SALVIN J, SELLINGER B, et al. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J Med Genet 1993: 30: SEDIVA A, BARTUNKOVA J, ZACHOVA R, et al. Early development of immunity in diGeorge syndrome. Med Sci Monit 2005: 11: „Most of the patients are hemizygous for 22q11.2, some have defects in various loci on chromosome 10, about 10% of cases are familial (2, 3)„

Sources Bibliographic databases Clinical sources online

Pubmed –

Medscape -

Up-to-date –

Orphanet –

Good luck with Your essays and presentations !