An Employee-Owned Research Corporation 10/14/2015 Statistics in Environmental Epidemiology Research Robert P. Clickner Presentation at the 50th Anniversary Celebration of FSU’s Statistics Department April 17, 2009

An Employee-Owned Research Corporation 10/14/2015 Environmental Epidemiology The study of the environmental causes of diseases in populations and how these risks vary in relation to intensity and duration of exposure and other factors.

An Employee-Owned Research Corporation 10/14/2015 Environmental Fate and Transport Emission Transport Exposure Body Burden Health Effects

An Employee-Owned Research Corporation 10/14/2015 Human Exposure Science The study of human contact with chemical, physical or biological agents occurring in their environments.

An Employee-Owned Research Corporation 10/14/2015 Typical Study Identify Target Population Design and Select a Sample of Participants Recruit Selected Participants Collect Data –Exposure Activities –Environmental Samples and Data –Health History –Biological Samples and Data Analysis, Report and Presentation

An Employee-Owned Research Corporation 10/14/2015 Environmental Sampling Air: indoor, outdoor, personal Water: tap, well, beach Paint Dust: wipes, vacuum Soil Food (duplicate diet) Building materials Fluff Heavy metals Particulate matter Pesticides PAH’s VOC’s Allergens EMF Radon Asbestos PCB’s

An Employee-Owned Research Corporation 10/14/2015 Biological Sampling Blood Urine Dermal Wipes Saliva Fingernails

An Employee-Owned Research Corporation 10/14/2015 Wayne Fuller: Every step in the process sounds easier than it is. Anonymous 8 th Grade science fair contestant: I learned that everything that you think will be the easy part of the experiment, will be the hardest tasks you will encounter.

An Employee-Owned Research Corporation 10/14/2015 Indoor Air Study at a Multi-building Campus: Reported Environmental Conditions Within and Between Buildings

An Employee-Owned Research Corporation 10/14/2015 Symptom experience (Misery Index) within and between buildings

An Employee-Owned Research Corporation 10/14/2015 Symptom Experience is Associated With Reported Environmental Conditions

An Employee-Owned Research Corporation 10/14/2015 Symptom Experience is Correlated with Reported Environmental Conditions

An Employee-Owned Research Corporation 10/14/2015 Blood Hg and frequency of seafood consumption

An Employee-Owned Research Corporation 10/14/2015 Hg & Omega-3 Fatty Acids in Fish

An Employee-Owned Research Corporation 10/14/2015 Regional Variations in Fish/shellfish consumption

An Employee-Owned Research Corporation 10/14/2015 Hg Intake via Fish/Shellfish Consumption

An Employee-Owned Research Corporation 10/14/2015 Blood Mercury

An Employee-Owned Research Corporation 10/14/2015 A weak association

An Employee-Owned Research Corporation 10/14/2015 How statistics affects your life -

An Employee-Owned Research Corporation 10/14/2015 Presence and Condition of Lead Based Paint by Construction Year

An Employee-Owned Research Corporation 10/14/2015 Multi-Stage Sample – National Survey of Lead and Allergens in Homes 96 M homes (= 1,404 PSUs) 75 PSUs (County Clusters) segments per PSU (= 39K HUs) 2-3 HUs per segment (831 HUs completed)

An Employee-Owned Research Corporation 10/14/2015 NSLAH: 75-PSU Sample

An Employee-Owned Research Corporation 10/14/2015 NSLAH – Within Home Sampling 4-6 rooms/Home Test specified components/surfaces

An Employee-Owned Research Corporation 10/14/2015 Listing housing units

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015 Measurement Error More than just instrument error, also: Spatial variation Temporal variation Variation between survey staff (By John Rogers, Westat)

An Employee-Owned Research Corporation 10/14/2015 How does Measurement Error Bias Percentiles?

An Employee-Owned Research Corporation 10/14/2015 How Does Measurement Error Bias Regression Slopes?

An Employee-Owned Research Corporation 10/14/2015 Estimating Adjusted Percentiles

An Employee-Owned Research Corporation 10/14/2015 Health Effects of Kuwaitis’ Exposure to Oil Fires

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015 Air sampling equipment

An Employee-Owned Research Corporation 10/14/2015 Personal air monitor

An Employee-Owned Research Corporation 10/14/2015 Practice interviewing

An Employee-Owned Research Corporation 10/14/2015 The questionnaire

An Employee-Owned Research Corporation 10/14/2015 Health effects of children’s exposure to air pollutants

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015 Health effects of swimming in unclean beaches

An Employee-Owned Research Corporation 10/14/2015 Collecting Water Samples

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015 Develop Sand Sampling Protocol

An Employee-Owned Research Corporation 10/14/2015 Refine the protocol

An Employee-Owned Research Corporation 10/14/2015 Water sampling - schematic

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015

An Employee-Owned Research Corporation 10/14/2015 Surprise!

An Employee-Owned Research Corporation 10/14/2015 Westat’s report -