EVIDENCE FOR ABERRANT TH1 AND TH2 IMMUNE RESPONSE IN DRUG NAÏVE FIRST EPISODE PSYCHOSIS E. Karanikas, E. Ntouros, D. Nasioudis, T. Valamoutopoulos, D.Balaskas,

Slides:



Advertisements
Similar presentations
Is the sympathetic nervous system overactive in cancer? Ashika Sequeira Hayward House Nottingham City Hospital.
Advertisements

Treating Schizophrenia in Low And Middle Income (LAMI) Countries: Challenges and opportunities Treating Schizophrenia in Low And Middle Income (LAMI) Countries:
Schizophrenia and Intellect Presentation by: Bryan Lang Caroline Helfrich and Jessica Wright Thomas W. Weickert, Terry E. Goldberg, James M. Gold, Llewellen.
Orbitofrontal Cortex Abnormalities in Bipolar Disorder Adolescents. Pablo Najt Department of Psychiatry, University of Texas, Health Science Center at.
Cytokines Department of Microbiology. Important terms Cytokines: Proteinaceous messenger molecules of low molecular weight (usually of less than 30kDa),
INTRODUCTION Dysregulation of Hypothalamic-Pituitary-Adrenal, (HPA), axis has been hypothesized to participate in the emergence of psychosis, yet findings.
INTRODUCTION During last decades much evidence has been accumulated concerning the neuroendocrine aetiopathological basis of schizophrenia. Recently research.
INTRODUCTION The stress diathesis hypothesis of psychosis is one of the most prevailing models of the aetiopathology of psychotic disorders. Cortisol is.
SERUM LEVELS OF IGF-1 IN FIRST EPISODE PSYCHOSIS AND CHRONIC SCHIZOPHRENIA PATIENTS COMPARED TO HEALTHY CONTROLS E. Ntouros 1, E. Karanikas 1, P. Ntafoulis.
89-SrCl2 Serum Concentrations of IL-2 and TNF- a in Patients with Painful Bone Metastases: Correlation with Responses to 89-SrCl2 Therapy THE JOURNAL OF.
AB CD T-cell Phenotypic Profile in Pregnancy: Link Between Immune Activation and Exhaustion N Shah 1, N Imami 1, M Johnson 1. 1 Imperial College London,
Basic Immunology University of Tabuk Faculty of Applied Medical Science Department of Medical Laboratory Technology Mr.AYMAN.S.YOUSIF MSc.Medical Microbiology.
Barbara Pajk, M.N. University Psychiatric Clinic Ljubljana Barcelona,
Ron Beasley, PharmD Candidate Preceptor: Soheyla Mahdavian, PharmD
INCREASED CIRCULATING SERUM LEVELS OF TGFβ-1 AND IL-6 ARE ASSOCIATED WITH THE PROGRESSION OF CΗRONIC KIDNEY DISEASE IN ATHEROSCLEROTIC PATIENTS WITH TYPE.
Methods Interleukim6,Interleukin 1 ,Estradiol and Testosterone Concentrations in Serum and Follicular Fluid of females with stimulated and non-stimulated.
Going back to work or to study after a first-episode psychosis : the impact of an early intervention program over 5 years Amal Abdel-Baki (1,2), Geneviève.
Schizoaffective Disorder in Life
FIBROBLAST GROWTH FACTOR-23 AND HYPOVITAMINAEMIA D IN ANAEMIA OF TYPE 2 DIABETIC NEPHROPATHY Grigorios G. Dimas 1, Fotios S. Iliadis 1, Ilias E. Kanellos.
The Role of Insulin- Like Growth Factor-1 in Schizophrenia By Karen Kiernan.
SERUM CYTOKINE PATTERNS IN CELIAC DISEASE Shabab Naqvi & Ibrahim Ibrahim Mentor: Dr. Sanil Manavalan Columbia University, College of Physicians and Surgeons.
An Analysis of Age and Gender Influences on the Relative Risk for Suicide & Psychotropic Drug Self- Poisoning AH Dawson 1, NA Buckley 2, IM Whyte 1, P.
ParameterFactor or combination of factorsEta² Peak GainTask0.628 Group0.214 Latency to Peak GainGroup0.256 Initial AccelerationTask0.153 Group0.305 Task.
Mechanism for malaria: A look into the innate immune system Summer 2015, VFIC Carilion Sam Saylor with Dr. Tracy Deem Deem.
Age and treatment related local hippocampal changes in schizophrenia explained by a novel shape analysis method 1,2 G Gerig, 2 M Styner, 3 E Kistner, 3.
Date of download: 6/9/2016 From: Antipsychotics in Adults With Schizophrenia: Comparative Effectiveness of First-Generation Versus Second-Generation Medications:
Type D Personality and Chronic Kidney Disease as Predictors of Pro- and Anti- Inflammatory Cytokine Levels in Heart Failure Interleukin-6 (IL-6), tumor.
Date of download: 6/23/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Understanding the Inflammatory Cytokine Response.
Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Clinical and Immunologic Assessment of Patients With.
Considering depression characteristics and antidepressants in the inflammation-depression relationship Nicole Vogelzangs Department of Psychiatry /
Vasopressin and noradrenaline reduce LPS-induced monocyte TNF release
IMMUNE-PRIVILEGED FIELD(S): LOOKING LOCAL RECURRENCE AND SECOND PRIMARY TUMORS IN HEAD AND NECK CANCER FROM A DIFFERENT VIEWPOINT  Stergios Doumas, Alexander.
Proposed sites of action of current multiple sclerosis (MS) treatments
Reduced number of peripheral natural killer cells in schizophrenia but not in bipolar disorder – a computational deconvolution study Paweł Karpiński1,
Makaric, P. 1, Bosnjak, D. 1, Kekin, I. 2, Brecic, P. 1, Jelacic, P
Computational Modelling of Circuits Homework assignment, group 2
Sammour T, Singh PP, Su’a B, Zargar-Shoshtari K, Hill AG
Bošnjak, D. 1, Makarić P. 1, Rojnić Kuzman, M. 2
Scores on the NIH Toolbox Cognition Test Battery are Negatively Correlated with Plasma Cytokines in Patients with Schizophrenia. Ruchir Arvind Patel1,
The factorial structure of negative symptoms in medication naïve First Episode Psychosis sample Demjaha A, Galderisi S, Arango C, Rodriguez-Jimenez R,
Copyright Notice This presentation is copyrighted by the Psychopharmacology Institute. Subscribers can download it and use it for professional use. The.
Volume 137, Issue 5, Pages e1 (November 2009)
Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times  Axel Franke, MD, Wolfgang Lante,
Differentiation and Functions of CD8+ Effector T Cells
The Th17 immune response in renal inflammation
Malaria Vaccine Design: Immunological Considerations
Figure 2 Type 3 immunity and AS
T –HELPER CELL AMMAR HADI
Warren Strober, Ivan J. Fuss  Gastroenterology 
Volume 20, Issue 1, Pages (January 2012)
Investigating the Mental Disorder: Schizophrenia
Potential mechanisms of therapeutic synergy between epigenetic modulation and PD-1 pathway blockade. Potential mechanisms of therapeutic synergy between.
Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels.
Figure 5 Cytokine release and stimulation of cells during alemtuzumab treatment Cytokine release and stimulation of cells during alemtuzumab treatment.
BALB/c scid mice have higher levels of macrophage-stimulating cytokines in circulation compared with BALB/c control mice. BALB/c scid mice have higher.
Volume 18, Issue 4, Pages (April 2010)
Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome  Yongguang Lu, Lang Li, Hua Yan, Qiang.
John T. Chang, William J. Sandborn  Gastroenterology 
The gastrointestinal mucosa in health, CDI, and UC
Multiple Sclerosis is a neurological, immune-mediated disorder
Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.
Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,
Figure 3 Cytokine gene expression in PBMC stimulated with PPD or MBP in vitroCytokine messenger RNA transcripts were isolated from peripheral blood mononuclear.
Figure 2 CD4+ T-cell subsets fluorescence-activated cell sorting analysis in peripheral blood mononuclear cells of patients with multiple sclerosis treated.
Effect of CIA and treatment with 3,4-dichloropropionaniline (DCPA) on production of key serum inflammatory factors. Effect of CIA and treatment with 3,4-dichloropropionaniline.
Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. Inhibiting or altering.
Figure 1. Cross talk between the immune system and osteoclasts in osteoclastogenesis. Osteoclasts are derived from monocyte precursor cells. RANKL from.
Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass  Chung-Hsi Hsing, MD, Mei-Yi Hsieh, MS, Wei-Yu Chen,
Fig. 2. Effect of activated vitamin D on immune cells
Presentation transcript:

EVIDENCE FOR ABERRANT TH1 AND TH2 IMMUNE RESPONSE IN DRUG NAÏVE FIRST EPISODE PSYCHOSIS E. Karanikas, E. Ntouros, D. Nasioudis, T. Valamoutopoulos, D.Balaskas, F. Tsompanidou, D. Kourbetis 424 General Military Hospital, Psychiatric Clinic, Thessaloniki, Greece

Introduction-Hypothesis The inflammatory hypothesis of the aetiopathophysiology of psychosis has been recently suggested. There is evidence from the literature for aberrant immune balance in schizophrenia but the findings are hitherto only minimal regarding the First Episode of Psychosis(FEP). The aim of the present study was to test the hypothesis of differential pattern in cytokines relating to Th 1and Th 2 immune response in FEP.

Methods Two groups were involved representing drug naïve or minimally treated(<3 days) patients with First Episode Psychosis (FEP, n:28), and healthy controls (HC, n:23). All subjects were age matched males. T helper -1 and T helper -2 types cytokines, Interleukin (IL)- 1 β, IL-2, IL-5, IL-6, IL-8, IL-12, IL-4, IL-10, Interferon (IFN)- γ, Tumor Necrosis Factor (TNF)-a and TNF-β, were measured in serum. Psychopathological parameters were additionally determined with the five factorial edition of PANSS.

Results In the FEP group, TNF-a and IL-4 were significantly higher compared with the HC group, (p=0.031 and p= 0.008, respectively). The FEP group also showed a trend for higher IL-2 and IFN-γ (p=0.081 and p= 0.065, respectively). Regarding the factors representing psychopathology only the negative factor did exhibit significant positive correlation with IL1 β(r=0.46,p=0.014).

Conclusion/Discussion The evidence favors an activation of both Th 1 and Th 2 immune responses in FEP and stands in line with the recently suggested inflammatory pathophysiological hypothesis of psychosis.

References 1. Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B.(2011). Meta-analysis of Cytokine Alterations in Schizophrenia: clinical status and Antipsychotic Effects. Biol Psychiatry 70: Muller N, Schwarz M. (2010). Immune System and Schizophrenia. Curr Immunol Rev. 6(3): Potvin S, Stip E, Sepehry A, Gendron A, Bah R, Kouassi E. (2008). Inflammatory cytokine alteration in Schizophrenia: A Systematic Quantitative Review. Biol Psychiatry 63: