GRACE ORDUNG Polycythemia

What is Polycythemia? Abnormal increase in blood cells  Red, white and platelets Classified as a cancer Acquired not heredity Defect in gene JAK2 V617F

Symptoms, Complications and Risk Factors Itching, headache, dizziness, weakness, sweating, breathing problems, enlarged spleen, numbness, etc. Stroke, heart problems Increases with age, men more than women

Normal vs. Polycythemia Normal Hb  Male: g/dL  Female: g/dL Hematocrit  Male: %  Female % WBC: 3,500-10,500 cells/uL Platelets: ,000 platelets/uL PV Hb  Male: > 18.5 g/dL  Female: > 16.5 g/dL WBC: > 12,000 cells/uL Platelets: > 400,000 platelets/ uL

JAK2 V617F Gene Cause of defect unknown China Japan Union Hospital, Changchun, China  3935 donors Copenhagen City Heart Study  10,507 donors

Treatments Phlebotomies Asprinin, hydroxyurea, Interferon A Antihistamines Lifestyle changes

References