© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare www.geneticseducation.nhs.uk X-Linked Recessive Inheritance.

Slides:



Advertisements
Similar presentations
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Duchenne Muscular Dystrophy.
Advertisements

Down Syndrome This PowerPoint file contains a number of slides that may be useful for teaching of genetics concepts. You may use these slides and their.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Taking a family history.
Understanding patterns of inheritance
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Conditions caused by anomalies.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Inherited Pre-disposition.
Somatic Mutations in Cancer
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Inherited Pre-disposition.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Segregation of Alleles in.
X chromosome inactivation
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Inherited Pre-disposition.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Haemoglobinopathies This.
X-Linked Conditions: Case Scenarios
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare X Linked Inheritance Transmission.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Clinical photographs of.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Clinical photographs of.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Clinical photographs of.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Clinical photographs of.
Classification of Genetic Disorders
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare This PowerPoint file contains.
© 2009 NHS National Genetics Education and Development CentreSupporting Genetics Education for Health Down Syndrome This PowerPoint.
Understanding patterns of inheritance
X-linked dominant inheritance: the basics a tutorial to show how the genes segregate to give the typical pedigree pattern Professor P Farndon, Clinical.
Two copies of each autosomal gene affect phenotype.
What’s Your Blood Type? A B AB O.
Human Genetics EQ: How can genetic patterns be analyzed to determine dominant or recessive inheritance patterns?
Genetics and genomics for healthcare © 2013 NHS National Genetics and Genomics Education Centre Passing on genetic information.
Chapter 14: The Human Genome
Sex Linked Inheritance A human female, has 23 pair of chromosomes A human male, has 22 similar pairs and one pair consisting of two chromosomes that are.
X-linked recessive inheritance where the mother is a carrier: the basics a tutorial to show how the genes segregate to give the typical pedigree pattern.
Human Sex Chromosomes & linked Genes
Sex Determination Sex determined by genes found on the X and Y chromosome Females: egg produced with an X chromosome Males: ½ sperm cells contain X;
Human Genome Biology Ch 14.
Genetics: Sex-Linked Inheritance
The Human Genome Ch. 14. Human Chromosomes Karyotype = how chromosomes are arranged in pairs Humans have 46 chromosomes or 23 pairs The 23 rd pair are.
1 Human Genetics: Pedigrees. Pedigree Looks at family history and how a trait is inherited over several generations and can help predict inheritance patterns.
Date:01 December 2015 Time:6:30 – 9:30 pm Location:Emory University Presentation Room 308 Speakers:Dr. John Richardson National DMD Assoc. President Got.
X-linked recessive inheritance where the father is affected: the basics a tutorial to show how the genes segregate to give the typical pedigree pattern.
Sex-linked Traits. Sex determination  Sex chromosomes – determines the sex of an individual YY XX  Males have X and Y  Two kinds of gametes  Female.
Pedigree Analysis.
Two copies of each autosomal gene affect phenotype.
Sex-Linked Traits & Pedigrees.
X-linked recessive inheritance
Human Genetics EQ: How can genetic patterns be analyzed to determine dominant or recessive inheritance patterns?
Two copies of each autosomal gene affect phenotype.
When Something Goes Wrong…
Pedigree Analysis.
Different mode and types of inheritance
Two copies of each autosomal gene affect phenotype.
Objectives Relate dominant-recessive patterns of inheritance in autosomal chromosomes to genetic disorders. Describe patterns of inheritance in sex-linked.
Year 10, Pathway C 2012 New Generations.
Two copies of each autosomal gene affect phenotype.
Two copies of each autosomal gene affect phenotype.
Example of Trait = Albinism
Pedigrees.
The Human Genome Ch. 14.
Genetics: Sex-Linked Inheritance
Two copies of each autosomal gene affect phenotype.
Two copies of each autosomal gene affect phenotype.
Two copies of each autosomal gene affect phenotype.
S3: HEREDITY E1: SEX-LINKED TRAITS
Two copies of each autosomal gene affect phenotype.
Two copies of each autosomal gene affect phenotype.
Sex-Linked Traits.
Two copies of each autosomal gene affect phenotype.
Two copies of each autosomal gene affect phenotype.
Patterns of Inheritance
Two copies of each autosomal gene affect phenotype.
Two copies of each autosomal gene affect phenotype.
Sex-Linked Traits.
Presentation transcript:

© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare X-Linked Recessive Inheritance This PowerPoint file contains a number of slides that may be useful for teaching of genetics concepts. You may use these slides and their contents for non-commercial educational purposes. This presentation includes: Pedigrees showing inheritance pattern and features of X-linked recessive inheritance Examples of X-linked recessive conditions.

© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare X-linked Recessive Inheritance One copy of an altered gene on the X chromosome causes the disease in a male. = Hemizygote Male An altered copy on one of the X chromosome pair causes carrier status in a female. = Heterozygote XX XY Female

© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare X-Linked Recessive Inheritance l All men who inherit the mutation are affected l Carrier females are usually unaffected l Appears to skip individuals. Carrier female Affected male Normal male

© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare X-linked Recessive Inheritance Pattern: Males are affected in more than one generation, no affected females. Affected males are linked through unaffected females. Males do not transmit to males. X-linked: The altered gene is on the X chromosome. Males have only one X chromosome and if this is altered, will be affected. Females have two X chromosomes - one normal copy is usually sufficient for adequate cell function. Examples: include haemophilia and Duchenne muscular dystrophy.

© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Examples of X-Linked Recessive Conditions Fragile X syndrome Haemophilia Duchenne muscular dystrophy (DMD) Becker muscular dystrophy (BMD) Fabry disease Retinitis pigmentosa Alport syndrome Hunter syndrome Ocular albinismOcular albinism Adrenoleucodystrophy.Adrenoleucodystrophy.