David Marash-Whitman 11/20/13

KPC (Klebsiella pneumoniae carbapenemase) 18 infected patients 6 fatalities complete drug resistance persistent presence at NIH center

THE PROBLEM increased usage leads to decreased future effectiveness antibiotics are being used excessively development of new antibiotics is expensive finite source of future antibiotics

THE SOLUTION promote conservative use of antibiotics incentive to comply remove barriers to compliance

THE SOLUTION bioethical responsibility timelinessaffordability

THE SOLUTION bioethical responsibility timelinessaffordability

THE SOLUTION bioethical responsibility timelinessaffordability

THE SOLUTION promote conservative use of antibiotics increase incentive to comply remove barriers to compliance

THE SOLUTION Prove-It SepsisSeptifastSepsitest $50 6 hours 25 species $ hours 70 species $125 <1 hour 345 species

THE SOLUTION bioethical responsibility timelinessaffordability

THE SOLUTION bioethical responsibility timelinessaffordability

OUTCOMES accessibility of medical technology reduction of inappropriate antibiotic prescriptions

SHORT TERMPREVENTIONLONG TERM general health vaccination development of new antibiotics conservative use of antibiotics (in humans) (in animals) development of new antimicrobial therapies