VERIS ™ by Electro-Diagnostic Imaging, Inc VERIS ™ by Electro-Diagnostic Imaging, Inc. Redwood City, California, USA Complete integrated System for Visual Electrophysiology First in Multifocal Electrophysiology

Comprehensive Visual Electrodiagnostic Testing Traditional (ISCEV Standard) Testing EOG, Full-Field ERG & Flash VEP, Pattern ERG & VEP Multifocal Testing mfERG, mfVEP Automated Ring Ratio Analysis Optic Nervehead Component (Global Flash Paradigm) ...and more M-Sequence Full-Field ERG, Pattern VEP, Pattern ERG Full Kernel Analysis ./ Synthesis capability User-Defined Custom Recording and Analysis Protocols Customizable Reports

Apple OS X Platform Exceptionally stable VERIS data can be stored automatically to any local, network, or Internet-accessible storage device Choice of open or password-protected file locking of data, analysis settings, and recording settings files Easy creation of pdf copies of reports for electronic medical records or email communications without additional (3rd party) software Easy to learn and fun to use!

VERIS Platform FG1 FMS IV Mac Pro Available Stimulators: FMS IV EMS IV (not shown) Fresnel Ganzfeld 1 (FG1) Flat panel displays Ganzfeld II (not shown) Mac Pro Grass Amplifier

VERIS ™ 6 Software Four Levels Traditional CLINIC SCIENCE PRO Traditional ISCEV protocols only CLINIC All Pre-programmed tests Creating and editing reports SCIENCE All Pre-programmed tests, Creation of new stimulation modes Creation of new analysis schemes PRO All functions of SCIENCE Advanced kernel synthesis and modeling ability

Real-time Internet support from EDI Available to all VERIS users by appointment Real-time monitoring and control of your VERIS system from our California office for training and troubleshooting at your location Fully encrypted with security controls to ensure privacy of medical information Requires Internet connection

The Ganzfeld Stimulator The Conventional Flash ERG Response Response of the retina to a full-field flash derived by means of an electrode placed on or near the cornea of the eye. The basic stimulator used for the derivation of this response is The Ganzfeld Stimulator

ISCEV Standard Ganzfeld Protocols

Flash ERG Flicker ERG Flash VEP EOG The EDI Ganzfeld 2 Full-Size Ganzfeld Stimulator

The Fresnel Ganzfeld FG1 Supports all Ganzfeld functions

FG 1 in handheld use FG 1 is the only handheld Ganzfeld stimulator for binocular recording

The retina is not homogeneous in its anatomy and physiology. The distribution of dysfunction is often characteristic for the disease and helpful for diagnosis and disease management. Response Mapping with Multifocal Electrophysiology

mfERG mfVEP Hexagon array Monitor screen 120 scaled sectors stimulated with contrast reversing check patterns ~ 40 ° Corneal Electrode Amplifier Typical electrode placement Minimum 2 channels: 1 midline 1 lateral Computer Trace array Inion Right eye red Left eye blue 120 focal VEPs Response density Inter-ocular differences

Fundus Monitoring Stimulator FMS IV Permits monitoring the patient’s fixation during stimulation Single know spherical refraction with range > 20 diopteer For PERG PVEP mfERG mfVEP Stimulator unit includes: High resolution color display Eye camera for patient alignment IR fundus camera for fixation monitoring

Eye Monitoring Stimulator EMS IV Permits monitoring the patient’s eye during stimulation Single know spherical refraction with range > 20 diopters Stimulator unit includes: High resolution color display Eye camera for patient alignment For PERG PVEP mfERG mfVEP

Clinical recording of multifocal ERGs takes 2 to 7 minutes per eye. The time depends on The spatial resolution (Veris offers up to 509 stimulus areas within the central 45 deg) The electrode technique

Example from the Clinic: Hydroxychloroquine Toxicity

Hydroxychloroquine Retinopathy A small percentage of patients who take this drug for autoimmune disease develop a bullseye retinopathy. This retinopathy is, at best, only partially reversible when the patient is taken off the drug. For disease prevention, the mfERG is now often used for patient screening.

Relative sparing of center Para-central depression Relative sparing of center

P1 implicit times are within normal range!

Plot is automatically generated red area between outside 30 Divided by total red area Ring aveerages

The Multifocal VEP (mfVEP) Placing recording electrodes on the scalp over the visual cortex A sensitive test in unilateral and asymmetric diseases

Traces from the two eyes match well! Normal mfVEP Red traces : right eye Blue traces : left eye 200 nV 200 ms Traces from the two eyes match well!

Example from the Clinic: Optic Neuritis

Optic Neuritis on right eye acute phase Record Dated: 03-26-2007 Red traces : right eye Blue traces : left eye Right eye amplitudes severely depressed in central area.

Right eye amplitudes recovered but delayed in central area. Record Dated: 05-19-2007 Red traces : right eye Blue traces : left eye Optic Neuritis Recovery 1 Right eye amplitudes recovered but delayed in central area.

Recovery of delays suggests re-myelination of fibers. Record Dated: 07-23-2007 Optic Neuritis Recovery 2 Red traces : right eye Blue traces : left eye Recovery of delays suggests re-myelination of fibers.