Imunoglobulins – structure and function Production of immunoglobulins Genetic determination of immunoglobulin production Clonal selection theory.

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Presentation transcript:

Imunoglobulins – structure and function Production of immunoglobulins Genetic determination of immunoglobulin production Clonal selection theory

Antigen and epitope

Molecule of IgG

Hypervaribale region of immunoglobulin molecule binds epitope of the antigen

Variable region of immunoglobulin molecule

Isotype switching

Clonal selection theory

Downloaded from: StudentConsult (on 18 July :29 AM) © 2005 Elsevier Activation and differentiation of B-lymphocytes

Downloaded from: StudentConsult (on 18 July :29 AM) © 2005 Elsevier

Isotype The class or subclass of an immunoglobulin. Antigenic determinats are on constant part of immunoglobulin molecule.

Idiotype An antigenic determinant on the variable region of a specific antibody.

Interaction Idiotype-antiidiotype Shoenfeld Y: Nature Medicine 10, (2004)

IgG

Primary and secondary immune response gsbs.utmb.edu/microbook/ch001c.htm

Downloaded from: StudentConsult (on 18 July :29 AM) © 2005 Elsevier

IgM on B-cell membrane

Expression of surface immunoglobulins on B-cells

Downloaded from: StudentConsult (on 20 July :29 AM) © 2005 Elsevier Formation of Secretory IgA

Affinity: The strength of the binding between a single site of an antibody (one variable region) and an epitope. Avidity: The overall strength of interaction between and antibody and antigen. The avidity depends on affinity and the valency of interactions.

Antibody affinity

Antibody affinity

Antibody Avidity

Biological functions of immunoglobulin molecules Activation of complement system (IgG, IgM) Opsonization (particularly IgG) Neutralization of antigens (IgG, IgA, IgM) Adherence interference (IgA, IgG) Antibody dependent cellular cytotoxicity (ADCC) Agglutation, precipitation (IgG, IgM) Mast cells degranulation (IgE) Transport through placenta (IgG) Imunoregulation (mainly IgG)

Antibody dependent cellular cytotoxicity (ADCC)