BCHM2072/ THEORY PAPER MCQs

31. Which of the following statements regarding fat digestion is INCORRECT? A.Triglyceride is not soluble in water B.Bile salts are made in the liver but stored in the gall bladder C.Bile salt production involves adding polar residues on to cholesterol D.Lipoprotein lipase, attached to the inside of the gut wall, hydrolyses dietary fat E.The hydrolysis products of fat are re-esterified back to lipid by the intestinal cells before export into the blood stream T T T F T

32. Person A is eating a normal fat diet but taking a drug which inhibits fat digestion. Person B is eating a diet in which the fat has been replaced by Olestra. Which statement is INCORRECT? A.In both people, there would be little rise in level of chylomicrons in the blood stream after a meal B.Both people would experience flatulence C.The faeces of both individuals would be relatively buoyant D.Fat soluble vitamin uptake would be compromised in both subjects E.Bile salts would not be produced in either person T T T T F

33. Which of the following is NOT a fate of cholesterol in mammalian tissues? A.Acetyl CoA B.Incorporation into VLDL C.Incorporation into plasma membranes D.Cholesterol esters E.Steroid hormones !! Is

34. Dietary cholesterol is transported from the liver: A.On carnitine B.In chylomicrons C.In HDLs D.Freely dissolved in solution without attachment to a carrier E.In VLDLs N Y N N N

35. Ketone bodies are transported to tissues: A.Freely dissolved in solution without attachment to a carrier B.In chylomicrons C.On carnitine D.In HDLs E.In VLDLs Y N N N N

36. An inhibitor of the interaction of VLDL with target tissues would: A.Inhibit the uptake of dietary fat in the intestine B.Inhibit the transport of fat from the liver to the tissues C.Increase the production of LDLs in the bloodstream D.Inhibit the release of fatty acids from adipose tissue E.Increase the uptake of dietary cholesterol by cells from LDLs N Y N N N

37. Below is a number of strategies used to lower serum cholesterol levels. Which strategy is designed to encourage cells to express more LDL-receptors? A.Increasing the consumption of omega-3 fatty acids. B.Reducing the intake of meat and dairy products C.Treatment with resins that block bile salt reabsorbtion D.Treatment with statins E.Ingesting sterols of plant origin N N N Y N

Use graphs (A-E) to answer Questions (38-40) A volunteer has starved for 3 days and a number of biochemical measurements have been made over the course of that time. Time “0” is the beginning of the post absorptive period (ie. when the last meal has been completely absorbed).

38.Which graph (A-E) represents the concentration of glucose in the bloodstream? 39.Which graph (A-E) represents the blood ketone body concentration? 40.Which graph (A-E) represents the phosphorylation of liver glycogen phosphorylase? Rapid initial decrease, followed by leveling off. Steady increase… eventually leveling off but perhaps not after 3 days. Rapid initial increase, maximum after just a few hours. A D C