The Top 20 Drugs Your Dental Patient is Taking: Drug Interactions and Oral Manifestations Ronald S. Brown, DDS, MS

The Top Twenty Prescriptions Rxlist.com/top200.htm 2002 drugs New & Refill

#1, #1 - #4 Hydroxycodone/APAP #3 l Oral narcotic analgesic l abuse potential

#2, #2 - #8 Lipitor #62 l atorvastatin l cholesterol lowering agent

#3 Atenalol, #4, #5 l Previous brand name Tenormin l Beta blocker – selective B1 l Negative on lipid profile

#4, #5, #4 - #2 Synthroid #3 l Levothyroxine Na l Thyroxin replacement drug

#5, #3, #3 - #2 Premarin #1 l Conjugated estrogen l hormone replacement l breast and ovarian cancer vs. osteoporosis

#6, #7, #19 - #7 Zithromax #9 l Azithromycin l antibiotic l new generation erythromycin l less drug interactions

#7, #8 Furosemide l Furosemide l Diuretic (very potent) l Dry mouth

#8, #9, #14 - #15 Amoxicillin #33 l Broad spectrum antibiotic l Good penetration l Gram positive organisms

#9, #10, #9 - #9 Norvasc #10 l Amlodipine besylate l Long-acting calcium channel blocking agent l drug-induced gingival overgrowth/hyperplasia

#10, #14, #17 Hydrochlorothiazide l HCTZ l Diuretic l Decreases lipid profile l K+ loss l Dry mouth

#11, #11, #10 Alprazolam l Alprazolam/Xanax (one of the brand names) l Sedative-hypnotic l Benzodiazepine class of drugs l Anti-anxiety

#12, #12, #8 - #13 Albuterol Aerosol #18 l Albuterol (Ventolin) l B2 receptor agonist l Asthma medication

#13, #16, #18 - #12 Zoloft #11 l Sertraline l 5HT re-uptake inhibitor l Dry mouth

#14, #17 Paxil l Paroxetine l 5HT reuptake inhibitor l Antidepressant l Dry mouth

#15, Zocor l Simvastatin l Cholesterol lowering

#16, Prevacid l Lansoprazole l H1 blocker l GERD

#17, #20, #21 Ibuprofen l NSAID l Analgesic, antipyretic l GI problems, ulcers l Increased bleeding l Drug interactions l Asthma

#18, #18 Triamterene/HCTZ l Diuretic l Combination HCTZ and K+ sparing l Dry mouth

#19, #13 - #20 Cephlexin #27 l Cephlosporin l Staph activity l Cross-reacts - allergy with penicillin – 5 -15%

#20 Celebrex l Celecoxib l Selective Nsaid\Cox II inhibitor l Analgesia