Aging-Related Memory Disorders Alzheimer’s Disease From Mechanisms of Memory by J. David Sweatt, Ph.D.

Amyloid Plaques and Neurofibrillary Tangles Image by Poul Jorgensen, Claus Bus, Niels Pallisgaard, Marianne Bryder, and Arne Lund Jorgensen

A B C Terminus N Terminus Crystal Structure of Amyloid Beta Peptide Watson et al (1998) Biochemistry 37:

 Amyloid Precursor Protein (APP) Price, Sisodia and Borchelt (1998) Science 282:

Tg 2576 Tg PS1 A246E PS1 A246E FAD Mutant Transgene Accelerates Amyloid Plaque Pathology in Tg2576 Transgenic Mice Dineley et al (2002) J. Biol Chem. 277:

Fear Conditioning percent freezing Cued percent freezing Context 2 Pairings percent freezing Training APP K670N, M671L n=9 Double n=9 Wild Type n=9 PS-1 M146L n= Dineley et al (2002) J. Biol Chem. 277:

Diagnosing AD a: Neuritic Plaques b: Diffuse Plaques c: Neurofibrillary Tangles d. Amyloid in blood vessel walls Khachaturian and Radebaugh (1996). Boca Raton: CRC Press.

A B From Wang et al. (2000) The Journal of Biological Chemistry 275: The Cholinergic Hypothesis of AD