Gastroscope Advisor: Dr. Ata Akin Design Team: Casey Gavinski Kenneth Hoyt Ashish Patel Kalpesh Trivedi

Problem Background  Diabetes Mellitus  Gastroparesis  Techniques for Diagnosis Invasive Non-invasive

Methods of Diagnosis  Nuclear Medicine Test Patient consumes small amount of radioactive material Scanner monitors amount of radioactivity in stomach  Upper Gastrointestinal (GI) Endoscopy Test Camera inserted into digestive tract Visually examines stomach  Intraluminal Manometry Baloon inserted into stomach Measures pressure generated by stomach contractions  Electrogastrography (EGG) Invasive

Electrogastrography  Measurement of Gastric Myoelectrical Potential Signals Electrodes placed on abdominal surface Testing performed during states of Fasting and Postprandial Correlation between EGG signals and gastric motility Non-Invasive !!

EGG Signal  Gastric Myoelectrical Signals (500μV)

EGG Signal  Primary Frequency Component 3 cpm (0.05 Hz)

Existing EGG Systems  Signal Measurement Bandwidth 1-18 cpm ( Hz) Primary Frequency  Stand Alone Mobility Limited  Portable No Graphical Display Not Stand Alone

Gastroscope  Portable  Stand Alone System  Graphical Display  Increased Bandwidth

EGG Signal  Secondary Frequency Component 50 – 80 cpm (0.8 – 1.3 Hz)

Why the 50 to 80 cpm ?  3cpm range requires monitoring throughout fasting and postprandial states. (Differential Comparisons)  50 to 80 cpm range provides consistent results with a short time reading.  50 to 80 cpm range closely correlated to Intraluminal Manometry Test in dogs. (Diagnostic Charts Available)  Create look-up charts for faster more accurate diagnosis.

Gastroscope System Architecture

Analog Signal Processing  DC Amplifier Instrumentation Amplifier Gain > 10,000 Low Noise  Filter Low Pass Flat Response Sharp Roll-off

Amplifier Schematic

Printed Circuit Board (PCB)

Amplifier Response  Amplifier and filter response to an input of 100 μv at 1 Hz

Amplifier Response (Cont’d)  Amplifier and filter response to an input of 100 μv at 15 Hz

Amplifier Response (Cont’d)  Amplifier and filter response to an input of 1 mv at 1 Hz

Amplifier Response (Cont’d)  Amplifier and filter response to an input of 1 mv at 15 Hz

DSP Flow Chart

Matlab Simulation

Matlab Simulation (Cont’d)

 Laptop Based Design Near Real Time Data Analysis LabVIEW Software Data Storage in Spreadsheet Format GUI Interface Portable Research Applications IRB Approved Alternative System Design

Future Work  Integrated System  DSP Based Architecture  Properly Configured ADC  Touchscreen Display (LCD)

Senior Design Expenditures

4 Year Financial Estimation Note: Production at $600 per unit is assumed as follows Year 1 – 20 units Year 2 – 30 units Year 3 – 40 units Year 4 – 50 units

National Instruments DAQ AI 16E Amplifier Fiter EGG SYSTEM START Freq = Mag = Power = Laptop STOPRESET SUMMARY Summary of System Design