Upper respiratory tract neoplasms. Benign Papilloma  Occurs in nose, sinuses, larynx (occasionally also in lower airways  Associated with human papilloma.

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Presentation transcript:

Upper respiratory tract neoplasms

Benign Papilloma  Occurs in nose, sinuses, larynx (occasionally also in lower airways  Associated with human papilloma virus types 6 and 11  Laryngeal lesions commoner in children – can occlude airway

Vocal cord polyps Benign non-neoplastic nodules in smokers and those putting strain on vocal cords “singers nodules”

Nasopharyngeal carcinoma Great geographical variation in incidence  Asia (Far East)  Africa  Sporadically elsewhere

Nasopharyngeal carcinoma Strong epidemiological and biological association with Epstein-Barr virus (detectable in tumour) Other factors – diet smoking Present with neck node enlargement and/or nasal symptoms

Histopathology Undifferentiated Differentiated (squamous cell) No prognostic difference Tumour frequently has a dense lymphocytic infiltrate (it is sometimes known as lymphoepithelioma)

Behaviour Spreads to lymph nodes Very sensitive to radiotherapy

Laryngeal carcinoma Smoking related Usually on the vocal cord Squamous cell carcinomas Preinvasive dysplastic stage is recognised

Laryngeal carcinoma Effects by local tissue destruction (loss of voice) Neck node metastases