Breast disease MUDr. Petr Šafář, CSc.. Anatomy of female breast.

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Presentation transcript:

Breast disease MUDr. Petr Šafář, CSc.

Anatomy of female breast

Breast examination

Benign breast disease Fibrocystic breast disease Adenosis – glandular prolif. Ductal hyperplasia – intraductal papilloma Cystosarcoma phyllodes – 80% benign fibroadenoma

Incidence of breast cancer

Breast cancer – age distribution

WHO classification Non-invasive carcinoma-ductal carcinoma in situ ( DCIS ) +lobular carcinoma in situ ( LCIS ) Invasive carcinoma - invasive ductal carcinoma (NST,NOS) invasive ductal carcinoma with dominant intraductal component, invasive lobular, carcinom mucinous, carcinom papillary, carcinom tubular, adenoid cystic carcinoma, carcinom sekretoric (juvenile) carcinoma apocrine, Paget´s carcinoma of breast nipple

Breast cancer treatment Surgery - radical mastectomy vs. Segmentectomy, TE+SLNB Adjuvant radiotherapy Adjuvantní chemotherapy Biologic therapy – herceptin Hormonal therapy

Complications of breast surgery Pneumothorax – radical mastectomy Vulneration of axillary vessels Vulneration of plexus brachialis Late complications – lymfoedema of prox.extr.