Hemophilia A By Saad Mukaty

Definition of Hemophilia  Hemophilia (A) is a rare disorder in which blood doesn’t clot normally because it lacks important blood clotting proteins. A person with hemophilia may bleed for a longer time after getting injured. This disorder affects the knees, ankles, or elbows.

Description of the symptoms  Increased bleeding after surgery or trauma is characteristic of hemophilia  Bleeding into the joints is signs of hemophilia. Knees and ankles are likely affected. The blooding causes swilling on the joints spaces, a lot of pain, and over time it could move its location. Over time joints gets damage then it need a replacement surgery.  Bleeding into the muscles may occur with hematoma formation.  Bleeding from the mouth or nose can also occur.  Bleeding from the stomach can lead the blood in the stool.  Bleeding from the urinary tract can lead to blood in the urine.  Bleeding in the brain or skull can lead to symptoms such as nausea, vomiting, and/or lethargy.

Cause of the hemophilia  Hemophilia (A) is caused by a mutation in the gene for factor VIII, there is deficiency of this clotting factor. Hemophilia is an inherited genetic condition and that’s simple to understand it way passed down through families. It is caused by a weakness in the gene that controls how the body makes blood-clotting factors (Vlll) These genes are located on the X chromosome, making hemophilia an X-linked recessive disorder. This disorder is a mutation because it does cause a change which is the blood clotting factors.

How the hemophilia is inherited  Hemophilia (A) is inherited in an X linked recessive pattern. The genes related to these conditions are located on the X chromosome, which is one of the two sex chromosomes. Males have only one X chromosome and one change copy in enough to cause the disorder hemophilia is a sex linked recessive disorder.

How hemophilia is treated  The most well known and the best option of treatment is replacement of the blood clotting factors. Clotting factors can be purifies from human donor blood or it can be made in labs using methods that don’t need human donors. This therapy is known as the Replacement Therapy. However, There are also a lot of medication that is recommended by the doctors such as pills and vaccines.

How the hemophilia is diagnosed  Screening tests and clotting factor tests are the best way to diagnosis. Screening tests are blood tests that show if the blood is clotting properly. Clotting factor tests are also known as factor assays, they required diagnosing a bleeding disorder.

How many and what type of people are likely to have the hemophilia  The forms of hemophilia occur much more commonly in men more then women. Hemophilia A is the most common type of the condition it is 1 in 4,000 to 1 in 5,000 males worldwide are born with this disorder. It doesn’t differ to which group it gets in but rather it affects everyone equally.

MLA Form Of Bibliography  "Hemophilia Symptoms, Causes, Treatment - What Are the Signs and Symptoms of Hemophilia? - MedicineNet." MedicineNet. N.p., n.d. Web. 07 June  "HoG Handbook." How Hemophilia Is Inherited Genetics HoG Handbook Hemophilia of Georgia. N.p., n.d. Web. 07 June  "Diagnosis." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 13 Sept Web. 07 June  "Hemophilia FAQs." « IHTC. N.p., n.d. Web. 07 June  "Hemophilia." - Mayo Clinic. N.p., n.d. Web. 07 June  "Hemophilia Symptoms, Causes, Treatment - What Causes Hemophilia? - MedicineNet." MedicineNet. N.p., n.d. Web. 07 June 2015.

Sources that I used:     faqs/  