Table 2.1.1: New Transplant Rate per million population (pmp), Year New transplants New transplant rate pmp Figure 2.1.1: New transplant rate, New transplant rate, pmp Year Rate, pmp

Table 2.1.2: Types of Cornea Transplant, Year1998 (N = 119) 1999 (N = 122) 2000 (N = 126) 2001 (N = 221) 2002 (N = 203) No.% % % % % Penetrating Keratoplasty Lamellar Keratoplasty Patch Graft for Cornea Patch Graft for Sclera Cornea Scleral Keratoplasty No data Year2003 (N = 165) 2004 (N = 184) 2005 (N = 192) TOTAL (N = 1332) No.% % % % Penetrating Keratoplasty Lamellar Keratoplasty Patch Graft for Cornea Patch Graft for Sclera Cornea Scleral Keratoplasty No data

Table 2.2.1: Gender distribution, Year1998 (N = 119) 1999 (N = 122) 2000 (N = 126) 2001 (N = 221) 2002 (N = 203) GenderNo.% % % % % Male Female No data Year2003 (N = 165) 2004 (N = 184) 2005 (N = 192) TOTAL (N = 1332) GenderNo.% % % % Male Female No data

Table 2.2.2: Ethnic distribution, Year1998 (N = 119) 1999 (N = 122) 2000 (N = 126) 2001 (N = 221) 2002 (N = 203) Ethnic groupNo.% % % % % Malay Chinese Indian Bumiputra Sabah Bumiputra Sarawak Others No data Year2003 (N = 165) 2004 (N = 184) 2005 (N = 192) TOTAL (N = 1332) Ethnic groupNo.% % % % Malay Chinese Indian Bumiputra Sabah Bumiputra Sarawak Others No data *Others: Non Malaysian

Figure 2.2.1: Ethnic distribution, Percent Ethnic group Malay Chinese Indian Bumiputra Sabah Bumiputra Sarawak Others

Table 2.2.3: Age distribution of cornea transplant recipient patients, Year1998 (N = 119) 1999 (N = 122) 2000 (N = 126) 2001 (N = 221) 2002 (N = 203) Age group (years)No.% % % % % >= Mean SD Median Minimum 4 months52 months5 months1 Maximum Year2003 (N = 165) 2004 (N = 184) 2005 (N = 192) TOTAL (N = 1332) Age group (years)No.% % % % >= Mean SD21 Median Minimum5 months2 months Maximum Age=date transplant-date birth; age if provided

Figure 2.2.2: Age distribution of cornea transplant recipient patients, Percent Year years years years years >=60 years

Table 2.2.4: Primary diagnosis, Year1998 (N=119) 1999 (N=122) 2000 (N=126) 2001 (N=221) 2002 (N=203) Primary DiagnosisNo.% % % % % Corneal scar Keratoconus Microbial keratitis Other (non pseudophakic) bullous keratopathy Corneal perforation (non microbial) Pseudophakic bullous keratopathy Failed previous graft Corneal dystrophy Congenital opacity Microbial keratitis + Corneal perforation Others No data

Table 2.2.4: Primary diagnosis, Year2003 (N=165) 2004 (N=184) 2005 (N=192) TOTAL (N=1332*) Primary DiagnosisNo.% % % % Corneal scar Keratoconus Microbial keratitis Other (non pseudophakic) bullous keratopathy Corneal perforation (non microbial) Pseudophakic bullous keratopathy Failed previous graft Corneal dystrophy Congenital opacity Microbial keratitis + Corneal perforation Others No data *1219 patients have 1 primary diagnosis, 104 have 2 primary diagnoses, 4 patients had 3 diagnoses, and 1 patient had 4 diagnoses

Figure 2.2.3: Primary Diagnosis in Recipients, CS= Corneal Scar KC= Keratoconus MK = Microbial keratitis PBK= Pseudophakic bullous keratopathy

Table 2.2.5: Indications of cornea transplant, Indication of transplant2004 (N = 184) 2005 (N = 192) Total (N = 376) No.% % % Optical Tectonic Therapeutic Tectonic + Therapeutic Optical + Tectonic Optical + Tectonic + Therapeutic Others No data

Table : Number of cornea transplants with complete data set Total No.% % % Total no. of cornea transplants performed No. of cornea transplants with notification complete data set

Table : No of previous grafts in grafted eye, Graft Number2004 (N=138) 2005 (N=158) Total (N = 296) No.% % %

Table : Ocular co-morbidity, (N=138) 2005 (N=158) Total (N = 296) Ocular co-morbidityNo.% % % Any ocular co-morbidity (a to c below) a) Cornea vascularisation Superficial vascularisation Deep vascularisation b) History of glaucoma c) Current ocular inflammation *Patient might have multiple ocular co-morbidity

Table : Pre-operative vision, (N=138) 2005 (N=158) Total (N = 296) Unaided VANo.% % % 6/ / / / / / / / / / / / CF HM PL NPL No data

Table : Source of Donor Cornea Tissue, (N=138) 2005 (N=158) Total (N = 296) Source of donorNo.% % % Local USA Sri Lanka No data If Local, ethnic group:  Malay  Chinese  Indian  No data

Figure : Source of Donor Corneal Tissue, Percent Year Local USA Sri Lanka

Table : Donor age distribution, (N=138) 2005 (N=158) Total (N = 296) Age, yearsNo.% % % >= Mean 5657 SD Median Minimum 83 3 Maximum 7879

Figure : Donor age distribution, Fraction Age of Donor (years)

Table : Preservation media, (N=138) 2005 (N=158) Total (N = 296) Preservation mediaNo.% % % Optisol GS MK Medium Moist Chamber No data Figure : Preservation media, Percent Year Optisol MK Medium Moist Chamber

Table : Cause of death in cornea donors, (N=138) 2005 (N=158) Total (N = 296) Cause of death No.% % % Cardiac / Circulatory System Cerebrovascular System Malignancy Trauma / Accident Respiratory System Others No data

Table : Type of surgery, (N=138) 2005 (N=158) Total (N = 296) Type of surgeryNo.% % % Penetrating Keratoplasty Lamellar Keratoplasty Patch Graft for Cornea Patch Graft for Sclera Cornea Scleral Keratopalsty

Table : Type of Combined surgery, (N=138)* 2005 (N=158)** Total (N = 296) Combined surgeryNo.% % % No. of patients with combined surgery (a) Glaucoma surgery (b) Cataract Extraction (c ) IOL (d) Retinal Surgery + Internal Tamponade (e) Anterior vitrectomy (f) Others *14 patients had 2 types of surgeries and 1 patient had 3 types of surgeries, combined with the corneal transplant surgery **11 patients had 2 types of surgeries combined with the corneal transplant surgery.

Table : Recipient Cornea Trephined Size, (N=138) 2005 (N=158) Total (N = 296) Graft size, mmNo.% % % No data Mean SD 111 Median Minimum 222 Maximum

Table : Difference in trephined sizes of recipient and donor corneas, (N=138) 2005 (N=158) Total (N = 296) Difference in Graft size, mmNo.% % % Same size No data

Table : Suture Technique, (N=138) 2005 (N=158) Total (N = 296) Suture Technique No.% % % Interrupted only Continuous only Combined

Table : Stock and flow Year2004 No.% New transplant On follow up15082 Lost to follow up3418 Dead00 Table : Post transplant graft status (Optical and Non-Optical) 2004 (N = 150) No.% Graft survival Graft failure 3020 Table : Post Transplant graft Status by Optical and Non-Optical Indication 2004 (N = 150) Optical (N = 99)Non-Optical (N = 51) No.% % Graft survival Graft failure * Subjects with both optical & non-optical indications were classified into the optical group

Table : Causes of graft failure 2004 No.% Graft Failure 3020 Cause of Failure Primary graft failure or Primary Endothelial decompensation 413 Recurrence of primary disease 413 Late Endothelial decompensation 827 Glaucoma 517 Infection 413 Graft rejection 620 Others 723 No data 310 *Each patient may have more than one cause of graft failure * Data represents causes from surgeons who provided a complete data set

Table : Available data on post corneal transplant vision Unaided Vision (N = 150)Best Corrected Visual Acuity (N = 150) No.% % Data available No data Table : Post transplant Unaided Vision (Optical and Non-Optical) 2004 (N = 137) Post transplant Unaided Vision No.% 6/6 32 6/9 54 6/ / / / / / / / / /60 10 CF 1612 HM 1914 PL 64 NPL 54

Figure : Post transplant Unaided Vision Percent Unaided Vision percent 6/6 6/9 6/12 6/18 6/24 6/36 6/60 5/60 4/60 3/60 2/60 1/60 CF HM PL NPL

Table : Post transplant Best Corrected Visual Acuity (Optical and Non-Optical) 2004 (N = 45) Post transplant best corrected Visual Acuity No.% 6/6 49 6/ / / / / / / / / / /60 12 CF 24 HM 12 PL 00 NPL 00

Figure : Post transplant Best Corrected Visual Acuity Percent Best Corrected Visual Acuity percent 6/6 6/9 6/12 6/18 6/24 6/36 6/60 5/60 4/60 3/60 2/60 1/60 CF HM PL NPL

Table : Post transplant Unaided Vision by Optical and Non-Optical indication 2004 (N = 137) Optical (N = 94)Non-Optical (N = 43) Post Transplant Unaided Vision No.% % 6/ / / / / / / / / / / / CF HM PL NPL * Missing unaided vision excluded

Figure a: Post transplant Unaided Vision by Optical indication Percent Unaided Vision percent 6/6 6/9 6/12 6/18 6/24 6/36 6/60 5/60 4/60 3/60 2/60 1/60 CF HM PL NPL

Figure b: Post transplant Unaided Vision by Non-Optical indication Percent Unaided Vision percent 6/6 6/9 6/12 6/18 6/24 6/36 6/60 5/60 4/60 3/60 2/60 1/60 CF HM PL NPL

Table : Factors for Post-op Best Corrected Visual Acuity of worse than 6/ No.% Post BCVA worse than 6/ Factors High astigmatism420 Glaucoma15 Retinal Detachment00 Cataract420 Cornea Decompensation210 DM Retinopathy00 Others525 No data735 *Patient with BCVA worse than 6/12 might have more than one factor

Table 2.5.1: Stock and Flow 2004 No.% Total no. of cornea transplants performed No. of cornea transplants on follow-up15082 No. of outcome with complete data set7943 Table 2.5.2: Post transplant complications 2004 No.% Any complications4759 Complications Epithelial Problem715 Wound Dehiscence12 Suture infiltration / abscess49 Endophthalmitis00 Microbial keratitis613 Vascularisation511 Post-keratoplasty glaucoma1328 Graft Rejection817 No data1838 * Each patient may have more than one complication

Table 2.5.3: Post transplant graft rejection types 2004 No.% Graft Rejection810 TypesEpithelial225 Stromal113 Endothelial563 No data113 * Each patient may have more than one type of rejection