1 Exercise and Altitude Research conducted in many situations –expeditions to Mt Everest (8850m)(235 mmHg) –simulations in barometric chambers Various altitudes and pressures –at Pikes Peak research center in Colorado (4300m)(450mmHg) –as well, research with altitude populations in the Andes (Quechuas) and Himalayas (Sherpas) has provided interesting data Moderate altitude >1524m (5000ft) –Decreases in maximum O 2 consumption begin in most people Elite athletes may experience declines in VO 2 max as low a 580 m (1900ft) Fig 23-2,3 effect of altitude on VO 2 max –3% decline / 300m (1000ft) –O 2 cost of work is similar - perception of effort is greater - higher % of max Extreme altitude > 6000m(20000ft) –Progressive deterioration towards death

2 Acute Altitude Exposure Sea Level 760mmHg (PIO 2 159mmHg) Fig 23-1 less O 2 available –As barometric pressure decreases Less air in given volume –Less O 2 per volume of air same % O 2 as sea level (~ 21%) Hypoxia - low levels of oxygen –Oxygen transport capacity decreases with increasing altitude, even with compensations outlined below Table 23-1 Effects of Acute exposure –Increased resting and submaximal heart rate and ventilation –Increased catecholamine secretion –Decreased VO 2 max –Few acute changes in blood, muscle or liver

3 Human Responses With proper acclimatization humans can tolerate high altitudes –Table ability to adapt Slow ascent to 5500m (18000ft) can be accomplished with few symptoms –Recommend 2 weeks to adjust to altitudes up to 2300m –Additional week for each 610 m up to 4600m If ascent is rapid -AMS -acute mountain sickness - can occur within a few hours –Headache, nausea, irritability, weakness, poor appetite, vomiting, tachycardia, disturbed breathing Above 3000m AMS is common –Those with a blunted breathing response are more susceptible –Slow ascent can reduce risk of AMS –Acclimatization hikes are important

4 Pulmonary Function Ventilation increases further for first 2 weeks if exposure to an altitude –Hypoxia is driving force –Bicarbonate is excreted - increasing central and peripheral sensitivity HVR - Hypoxic Ventilatory Response –fig ventilation during exercise –Important to maintain Alv and Art O 2 –Which determines Max O 2 utilization –Elite athletes - often have blunted HVR Fig O 2 tensions at rest and exercise Observe dec in PaO 2 with intense ex –May be pulmonary gas exchange causing diffusion limitation at altitude –Partial P of O 2 determines driving force –Fig 23-6b - same transit time - dec driving force (slope) at altitude

5 pH Changes and Ventilation Higher ventilation decreases PCO 2 –Blood becomes more alkaline First Week Decrease bicarbonate level in cerebrospinal fluid resulting from active transport and kidney excretion –helps to normalize pH –improves respiratory control at altitude –influence of bicarbonate release on pH is limited - at high altitude blood is still alkaline Fig 23-6 a - O 2 Hb dissociation curve Higher ventilation inc PaO 2 but also cause shift of cure to left –tighter bond between Hb and O 2 –require lower PO 2 to release O 2 at tissues Bicarb excretion shifts curve back to right –Helps unloading of O 2 at tissues increased content of 2,3-DPG in rbc’s causes curve to shift further to the right –Advantageous only to 5000m - then impairs ability to pick up O 2 at the lungs

6 Cardiovascular Adjustments fig 23-7 Acute submaximal exercise – HR inc; SV ~ same; Q inc; VO 2 inc Acclimatized submaximal exercise –HR still high; SV dec, –Q dec 20-25% (after 1-2 weeks); –VO 2 ~same MAP - Mean Arterial BP - gradually increases with exposure –Due to inc systemic resistance and vascular resistance in muscle –inc blood viscosity and catecholamines Above 3000m EPO stimulates Hb and Hct - requires several weeks –Time reduced with adequate energy, protein and iron intake

7 Acclimatization Rate Pressure Product - work load on heart (HR * Systolic BP) –Shown to inc 100% in some individuals with exercise above 3000m and above –Poses significant challenge to the heart Lungs - PAP - pulmonary Arterial P –Inc with altitude due to sympathetic stimulation Inc size of sm ms in pulmonary arterioles –Implicated in HAPE (high altitude pulmonary edema) Brain - hypoxemia - vasodilation –Implicated in HACE (cerebral edema) –Hypocapnea causes vasoconstriction in brain which can reduce vasodilation

8 Muscle Acclimatization During exercise –submaximal bld flow decreases by about 20-25% –Due to inc Norep and decreased Q –O 2 delivery maintained - through increased O 2 content in blood Inc myoglobin, buffering capacity, aerobic enzymes CS (small change) –Enhances tissue oxygenation and acid base balance Oxidative capacity - no change?? –Altitude native - low mito volume Activity limited by pulmonary ventilation and arterial oxygen content –Even unfit are thought to have sufficient Oxidative capacity at altitude –Endurance capacity increases with acclimatization (no change in VO 2 max)

9 Nutrition and Energetics Weight loss and muscles atrophy are common average g/day - –dehydration, energy deficit, increased activity level, inc BMR –High carbohydrate diet can help > 60% Exercise Energetics Lactate paradox - fig 23-8 –Blood lactate is higher at given power output with acute exposure compared to sea level and acclimatization –Paradox is that there is no change in VO 2 max with acclimatization Fig 23-9 –research suggests that acclimatization results in Dec Ep, (Nor Ep stays high) Reduced glycogen mobilization –Working ms oxidizes more of its own lactate - inc dependence on bld glucose

10 Fuel Metabolism Carbohydrates - thought to be preferred fuel - higher yield of ATP/O 2 CHO has very limited storage –Hypoglycemia and liver glycogen depletion common at altitude –Reduced with high carbohydrate diet Fat and Protein –Increased fat catabolism at altitude if diet is inadequate –Gluconeogenesis - loss of muscle mass also occurs with low CHO intake Working muscle shown to prefer CHO at altitude –Use of protein for gluconeogenesis has detrimental impact on long term exercise/work potential

11 Athletics at Altitude Table Mexico City Olympics (1968) –~ 2240m (7350ft) Improvements in short duration, high intensity activities –Reduced gravity and wind resistance Decreased endurance performance –longer than 800m Athletes benefit from 1-12 weeks of acclimatization Problem - reduced absolute training intensity at altitude-even if same relative % –Can not train as hard - detraining effect –Further - do not see improvements in sea level performance (reduction) –Reduced bld volume, buffering capacity, inc ventilation (more work)

12 Live High - Train Low Combine benefits of sedentary adaptations to altitude with maximal training stimulus near sea level Increased capacity to compete at moderate altitude –Recent research has also illustrated an increased capacity for exercise at sea level with live high- train low Levine, Stray-Gunderson and Chapman –Fig 21.5 (Brooks) –VO 2 Max and Running Endurance improved –3000m performance improved (elite) –Only some subjects were ‘responders’- significant EPO production with altitude Either live at m and drive down every day to train (<1200m) –This altitude found to stimulate rbc production, but to not cause AMS symptoms in athletes Or sleep in hypoxic tent with reduced oxygen tension (14%O 2 - PIO 2 106mmHg) –Stimulates adaptation while you sleep

13 Ergogenic Aids and Altitude Significant use of EPO and synthetic analog of EPO at Salt Lake City Olympics Several athletes stripped of there medals in cross country skiing Used darbepoietin - novel erythropoiesis stimulating protein Developed for the treatment of of chronic anemia in patients on renal dialysis –Longer half life than EPO, needs to be taken less frequently, but also stays in system longer making detection easier Currently, limits of absolute levels of Hb and/or Hct are in place –50% and 17g/dl (males )(varies with organization) Proposals for indirect analysis of soluble transferrin receptors and serum erythropoietin which can be done in minutes