1 Clayton Biotechnologies, Inc. One Riverway, Suite 1520 Houston, Texas Overview of Clayton Biotechnologies, Inc.

2 Clayton Biotechnologies, Inc. is a for-profit company which facilitates the commercialization of medical discoveries made by the Clayton Foundation for Research and its supporting entities. The Clayton Foundation for Research is a nonprofit medical research organization in Houston, Texas established in 1933 by Benjamin Clayton. The mission of the Foundation is two-fold: To transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. To conduct medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind

3 We conduct and fund medical research programs at leading universities, hospitals and academic institutions ■ Baylor College of Medicine ■ Baylor College of Medicine Texas Children's Cancer Center ■ North Carolina State University ■ Oregon Health and Science University ■ Salk Institute for Biological Studies ■ The University of Texas at Austin ■ The University of Texas Health Science Center at San Antonio ■ The University of Texas M.D. Anderson Cancer Center ■ The University of Texas Medical Branch at Galveston ■The University of Texas Southwestern Medical Center at Dallas ■ University of California, San Diego ■ University of Geneva

4 Some of our start-up companies Depotech, Inc.

5 Some of our Other Licensees

6 Products Brought to the Market Diagnostics Medical devices SCA6 diagnostic tests Complete Ataxia Evaluation Therapeutics

7 FEATURED TECHNOLOGIES VEGF/rGel – ADC targeting ocular neovascularization Drs. Rosenblum MD Anderson RTEF therapy for ocular neovascular disease Dr. Stout OHSU Urocortin to promote and preserve beta islet cells and to promote glycemic control Drs. Vale and Huising Filaggrin to treat Atopic Dermatitis Dr. Stout OHSU E-clonals: Fc engineering for aglycosylated antibodies Dr. Georgiou University of Texas, Austin Pluripotent Stem Cells for Neurotoxicology Testing Dr. Krause University of Geneva Vaccines and Diagnostics for the Ehrlichioses Dr. McBride University of Texas Medical Branch CRFR1 antagnoists to treat tauopathies such as Alzheimer’s Disease Dr. Sawchenko Salk Institute Cripto antagonists for the treatment of cancer Dr. Vale and Gray Salk Institute Antibodies to Srpx2 and Olmfl3 targeting angiogenesis Dr. Imhof University of Geneva Avicins, new class of triterpenes to treat cancer – IND approved package Dr. Gutterman MD Anderson

8 Any questions? Please contact us! Clayton Biotechnologies, Inc. One Riverway, Suite 1520 Houston, Texas