AIM 1 HYPOTHESIS: DETECTION AND DISCRIMINATION ARE ENHANCED BY PERIODIC INPUT. Our preliminary results establish new behavioral methods for detailed characterization.

Slides:



Advertisements
Similar presentations
Writing a Fellowship Part 1. My Fellowship History In my third year as a post-doc fellow I received a Leukemia and Lymphoma fellowship for senior fellows.
Advertisements

Sensory system tuning (filtering) and organization All sensory systems are designed to extract information from the environment Sensory systems are usually.
Proposal Development Guidelines for Signature Grantee Semi-Finalists The Covenant Foundation.
Graduate Training Program How To Prepare, and Prepare for Your Qualifying Exam.
Ten Fatal Flaws of NIH Grant Submissions (and how to avoid them) Steffanie A. Strathdee, PhD Thomas L. Patterson, PhD.
Specific Aims or Selling your Science in One Page Pedro Fernandez-Funez Assistant Professor of Neurology and Neuroscience
Writing your Specific Aims GHS workshop February 24, 2014 Martie Thompson, Ph.D. Research Professor, Clemson University
NIH Writing Your Specifics Aims CHIP Grant Workshop 2014 Amy Gorin, Ph.D. Listen Up! This is a critical section of your application.
B IOMEDICAL E NGINEERING Significance & Innovation Dawn M Elliott, PhD.
Effective January 25, 2010 and beyond Information from Part 5. Research Plan of NIAID’s NIH Grants Cycle Website.
A model for spatio-temporal odor representation in the locust antennal lobe Experimental results (in vivo recordings from locust) Model of the antennal.
Significance and Innovation Significance- The positive effect something is likely to have on other things Innovation- A new and substantially different.
Writing for Publication
Tips on NIH grant writing
NSF Doctoral Dissertation Improvement Grants Improve dissertation research – Provide funds not normally available to graduate students significant data-gathering.
NIH Mentored Career Development Awards (K Series) Part 3 Thomas Mitchell, MPH Department of Epidemiology & Biostatistics University of California San Francisco.
Project Overview and Objectives (or Specific Aims) as Proposal Roadmap June 2, 2009 Office of Proposal Development Tisha Gilreath Mullen Sara Trickie Nathan.
NIH Mentored Career Development Awards (K Series) Part 4
How to get that first NIH grant
Min Du Department of Animal Science How to develop a successful grant proposal.
Getting Funded: How to write a good grant
Formulating an important research question Susan Furth, MD, PhD Welch Center for Prevention, Epidemiology and Clinical Research
Effective proposal writing Session I. Potential funding sources Government agencies (e.g. European Union Framework Program, U.S. National Science Foundation,
Writing a Research Proposal
UAMS Department of Biochemistry and Molecular Biology
I NTRODUCTIONS. W HY HAVE AN INTRODUCTION ? To provide context for the study and to create a research space for yourself Follow the CARS ( c reate a r.
Aims and objectives Aim: Know of a range of approaches to resolving social complexities Objectives: Identify a range of community project ideas Relate.
Specific Aims Grant Writing Workshop Specific Aims Emelia J. Benjamin, MD, ScM The NHLBI’s Framingham Heart Study Boston University School of Medicine.
Writing Successful Research Grant Proposals
Formulating a Research Proposal
Grant Research Basics. Asking the Question  Before you start, you must have both clearly stated research question and primary outcome measure.  What.
Methodologies. The Method section is very important because it tells your Research Committee how you plan to tackle your research problem. Chapter 3 Methodologies.
Grant writing: what’s it about?. Who does grant writing?  Typically a person must have advanced to the level of independent investigator before being.
Proposal Development Sample Proposal Format Mahmoud K. El -Jafari College of Business and Economics Al-Quds University – Jerusalem April 11,2007.
Research Project Grant (RPG) Retreat K-Series March 2012 Bioengineering Classroom.
Why Do Funded Research?. We want/need to understand our world.
NATIONAL INSTITUTES OF HEALTH CHALLENGE GRANT APPLICATIONS Dan Hoyt Survey, Statistics, and Psychometrics(SSP) Core Facility March 11, 2009.
You Had Me at “Hello” Specific Aims Workshop Michael R. Blackburn, PhD Dean, Graduate School of Biomedical Sciences at Houston John P. McGovern Distinguished.
Health Care Systems EPI 247: Week 8 Health Care Systems EPI 247: Week 8 PART 2: HOW ORGANIZATIONS CHANGE Failure to Adapt: Implementation Gaps and System.
Grant writing 101 The Art of Flawless Packaging Scott K. Powers Department of Applied Physiology and Kinesiology Scott K. Powers Department of Applied.
National Institutes of Health AREA PROGRAM (R15) Thomas J. Wenzel Bates College, Lewiston, Maine.
GRANT WRITING FOR SUCCESS: TOP 10 REVIEWER CONCERNS AND GOOD/BAD GRANTS Grant Writing for Success LeShawndra N. Price, Ph.D., NIMH, NIH Henry Khachaturian,
Thoughts on grant writing David Fuller Dept. of Physical Therapy McKnight Brain Institute University of Florida GMS 6096: Introduction.
The Researcher - The Architect Written proposal - the detailed plans –problem and subproblems are stated –hypotheses / questions are articulated –terms.
Background (and significance) Section Things to remember: As your progress through the literature review be sure to highlight in summary sentences where.
What Makes a Proposal Successful Dr. George B. Stefano The State University of New York College at Old Westbury October 6, 2008.
Restructured NIH Applications One Year Later:
Insider Guide to Peer Review for Applicants Dr. Valerie Durrant Acting Director CSR Division of Neuroscience, Development and Aging.
Approach Section: The “Meat” of the Proposal INBRE Grant Writing Workshops 2015 Helen Beneš, Ph.D. Director, AR INBRE Developmental Research Project Program.
Critical Elements of Successful Research Proposals Writing Clear, Logical Specific Aims and Testable Hypotheses Children’s Research Institute Biostatistics/Informatics.
NIH Grant Application Writing Workshop Significance and Innovation S.P. Sugrue Feb
CHAPTER 16 Preparing Effective Proposals. PRELIMINARY CONSIDERATIONS  Conducting a Preliminary Assessment  Prior to Writing the Proposal  How Fundable.
Response to Prior Review and Resubmission Strategies Yuqing Li, Ph.D Division of Movement Disorders Department of Neurology Center for Movement Disorders.
The Daly Lab Personnel: Postdoctoral: Erich Staudacher Graduate students: Oakland Peters Esther Mwilaria (MS Sp 07) Undergraduate students: Faizan Kalwar.
Short and Sweet: Selling Your Science in 12 Pages ASBMR Grant Writing Workshop Friday, 15 October 2010 Toronto, ON Jane E. Aubin, Ph.D. Dept of Molecular.
R01? R03? R21? How to choose the right funding mechanism Thomas Mitchell, MPH Department of Epidemiology & Biostatistics University of California San Francisco.
Info-Tech Research Group1 Info-Tech Research Group, Inc. Is a global leader in providing IT research and advice. Info-Tech’s products and services combine.
Outline What is Literature Review? Purpose of Literature Review
Grant Writing Workshop Specific Aims
Opening sentence: Frame your topic in terms of importance to NIH/foundation mission Briefly summarize current knowledge on this topic; 2-3 sentences to.
Approach Section: The “Meat” of the Proposal
BU Career Development Grant Writing Course- Session 3, Approach
Dissecting the critical “Specific Aims” page of an NIH grant
K R Investigator Research Question
Bandit Thinkhamrop, PhD
UAMS Department of Biochemistry and Molecular Biology
Writing a good discussion & conclusion
Thomas Mitchell, MA, MPH Department of Epidemiology & Biostatistics
Why now? New requirement for all RACs in the next Request for Applications (RFA) Improve communications among all participants Increased need to identify.
Dissecting the critical “Specific Aims” page of an NIH grant MADISON HEDRICK, MA
Presentation transcript:

AIM 1 HYPOTHESIS: DETECTION AND DISCRIMINATION ARE ENHANCED BY PERIODIC INPUT. Our preliminary results establish new behavioral methods for detailed characterization of odor detection and discrimination thresholds. We show that detection thresholds are greatly enhanced when odor is pulsed at the wing beat frequency relative to a continuous stimulus. Using these methods we will manipulate odor pulse frequency, velocity, duty cycle, pulse-train duration and concentration in both tethered and restrained moths to test the working hypothesis that periodic input lowers detection and discrimination thresholds while concomitantly enhancing salience; hence olfactory learning will be enhanced. AIM 2 HYPOTHESIS: NEURAL REPRESENTATIONS OF ODOR ARE OPTIMIZED BY PERIODIC INPUT. Preliminary data, using stimuli matched to our behavioral studies, demonstrate that both the antennae and AL track pulsed stimuli and produce odor- dependent representations that are distinct from those of continuous stimuli. Using measures of antennal input, as well as intracellular, local field potential, and simultaneous behavioral and neural ensemble measures of AL processing, output and behavior, we will test the working hypothesis that the antenna and AL are more sensitive to periodic stimulation, and, that the AL produces more distinctive spatiotemporal representations at lower concentrations than to continuous stimulation. As written, why do these Aims suck?

As you write you specific aims section keep in mind: 1.Reviewers/panels have potentially ~100+ proposals to review as perhaps 16 hours to do it discussion for any one grant (if your lucky) 2.Only 2-3 primary reviewers (NIH) will have read your grant. 3.The rest don’t know your field. 4.The rest will be reading your SA page while the primary reviewers discuss why it should be discussed (or not) 5.If your grant comes up at the end of the day or on the last day people will be exhausted. Therefore the specific aims section MUST be devoid of details as possible As organized as possible: Clear hierarchical structure with logical flow Properly highlighted subtitles

What makes a good set of specific aims paragraphs? They fully address the central hypothesis They do not go beyond the central hypothesis They fill the identified gap in knowledge They are logically related to each other but…. They are functionally independent of each other (failure of one SA does not cripple the others) They are doable given: Your space/resources Your ability The limited time of the funding cycle

How are the specific aims paragraphs best articulated: They describe WHY you are going to do WHAT you propose They have a clearly articulated working hypothesis The working hypothesis is supported by preliminary data. They are limited in scope to what is feasible and to specifically addressing the central hypothesis.

The payoff paragraph: What will you provide at the end of this funding Three statements are needed and need to guide the reader. Tell them: 1.“The proposed research is innovative because…” 2.“The expected outcomes are…” 3.“These expected outcomes will have an important positive impact because…” This last sentence ties your results directly to filling the gap in the field and or moving the field forward.