Differential Gene Expression. Differential Gene Transcription What are the major differences between prokaryotic and eukaryotic genes? What are the major.

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Presentation transcript:

Differential Gene Expression

Differential Gene Transcription What are the major differences between prokaryotic and eukaryotic genes? What are the major differences between prokaryotic and eukaryotic genes?

Differential Gene Transcription

Promoters How do promoters work? How do promoters work?

Enhancer How is an enhancer different from a promoter? How is an enhancer different from a promoter? Activates use of promoter Activates use of promoter Activates promoters on same strand Activates promoters on same strand Doesn’t need to be adjacent to gene Doesn’t need to be adjacent to gene Doesn’t need to be upstream Doesn’t need to be upstream

Enhancer How can one identify presence of an enhancer? How can one identify presence of an enhancer? Why are they so important? Why are they so important?

Transcription Factors What are the major structural domains of these molecules? What are the major structural domains of these molecules? DNA-binding domain DNA-binding domain Trans-activating domain Trans-activating domain Protein-protein interaction domain Protein-protein interaction domain

Transcription Factors What is MITF? What is MITF? DNA DNA DNA-binding domain DNA-binding domain Protein-protein interaction domain Protein-protein interaction domain Trans-activating domain Trans-activating domain

Transcription Factors Why is PAX6 such an important molecule? Why is PAX6 such an important molecule?

Silencers What are silencers? What are silencers?

Transcriptional Control Of what value is DNA methylation? Of what value is DNA methylation? How has this been demonstrated experimentally? How has this been demonstrated experimentally? How does methylation work? How does methylation work?

Transcriptional Control What are insulators? What are insulators?

Transcriptional Control How does dosage compensation influence transcription? How does dosage compensation influence transcription? What are Barr bodies? What are Barr bodies? How does this relate to calico cats? How does this relate to calico cats?

RNA Processing What is the difference between nRNA and mRNA? What is the difference between nRNA and mRNA?

RNA Processing How is differential splicing of nRNA accomplished? How is differential splicing of nRNA accomplished? What is the difference between genome and proteome? What is the difference between genome and proteome?

Translational Control What are some of the factors that influence gene expression at the level of translation? What are some of the factors that influence gene expression at the level of translation?

Translational Control

Posttranslational Regulation What is meant by this level of regulation? What is meant by this level of regulation? How can it occur? How can it occur?

Controlling Gene Expression