 starter activity Casu marzu is a cheese made from unpasteurised goat’s milk. The cheese is left exposed so that a special cheese fly can lay its eggs on the cheese. The maggots hatch and eat the cheese helping to breakdown the fats and start the fermentation process. The cheese becomes very soft and liquid called lagrima seeps out. The maggots grow to about 8 millimetres long. When disturbed, they can launch themselves for distances up to 15 centimetres. The idea is you eat the cheese, maggots and all!

How did scientists discover the cause of disease? To explore the origins of germ theory & the work of Louis Pasteur work of Louis Pasteur  Aims

 Your task Read p Find out what a miasma was. Read p Find out what a miasma was. ‘Miasmists’ toured British cities sniffing out evil- smelling quarters and informing the authorities of the health hazard

What was a ‘miasma’? Common sense told people there was a connection between dirt & disease Common sense told people there was a connection between dirt & disease Miasma – poisonous fumes give off by decaying matter Miasma – poisonous fumes give off by decaying matter Strong-smelling herbs & spices countered the effects Strong-smelling herbs & spices countered the effects Ventilated hospitals improved chances of survival Ventilated hospitals improved chances of survival

 Your task Reading for gist. Read pp about the discovery of micro-organisms. You don’t need to take notes! Reading for gist. Read pp about the discovery of micro-organisms. You don’t need to take notes! What contribution did the following men make to the discovery of the causes of disease? What contribution did the following men make to the discovery of the causes of disease? Anthony van Leeuwenhoek Anthony van Leeuwenhoek Joseph Lister Joseph Lister Louis Pasteur Louis Pasteur

 Your task Imagine you have been asked to produce a film explaining the discovery of the causes of disease. You will be given a template for a storyboard. Sketch an image in each box showing the main stages in the discovery. The first box can provide the background and the last one can be the credits! Imagine you have been asked to produce a film explaining the discovery of the causes of disease. You will be given a template for a storyboard. Sketch an image in each box showing the main stages in the discovery. The first box can provide the background and the last one can be the credits!

 Your task Listen to the interview with Robert Koch, the scientist who developed Pasteur’s experiments into bacteria and developed theories on how they caused disease in humans and animals. Listen to the interview with Robert Koch, the scientist who developed Pasteur’s experiments into bacteria and developed theories on how they caused disease in humans and animals. How did he help the development of germ theory? How did he help the development of germ theory? What was secret of his success? What was secret of his success?

Koch’s contribution to germ theory Identified the bacterium caused anthrax Identified the bacterium caused anthrax Other bacteria, e.g. typhoid, TB, cholera identified in same way Other bacteria, e.g. typhoid, TB, cholera identified in same way Developed a technique to cultivate bacteria and used dyes to make them visible Developed a technique to cultivate bacteria and used dyes to make them visible

Secret of his success Built on previous knowledge (Pasteur & Co.) Built on previous knowledge (Pasteur & Co.) Repeated experiments to check results (through 20 generations of mice) Repeated experiments to check results (through 20 generations of mice) Improved testing technology, e.g. developing cultures & dyes Improved testing technology, e.g. developing cultures & dyes Robert Koch, German scientist in his laboratory

 Your task Read pp and create a spider diagram identifying the reasons why diseases were discovered at this time. Include the following categories: observation, new technology, medical knowledge, research teams, individual genius, chance, governments, warfare, other reasons Read pp and create a spider diagram identifying the reasons why diseases were discovered at this time. Include the following categories: observation, new technology, medical knowledge, research teams, individual genius, chance, governments, warfare, other reasons

Reasons for the discovery of diseases Observation – P conducted experiments using sterile flasks in different locations, identifying that particles in air caused decay Observation – P conducted experiments using sterile flasks in different locations, identifying that particles in air caused decay New technologies – K developed better ways of growing bacteria & stains to identify them; P & K used new microscope developed by Lister New technologies – K developed better ways of growing bacteria & stains to identify them; P & K used new microscope developed by Lister Medical Knowledge – P called his method of immunising chickens against cholera ‘vaccination’ after Jenner Medical Knowledge – P called his method of immunising chickens against cholera ‘vaccination’ after Jenner

Reasons for the discovery of diseases Research teams – P used teams of vets & doctors Research teams – P used teams of vets & doctors Individual genius – P said, ‘chance favours the mind which is prepared’ Individual genius – P said, ‘chance favours the mind which is prepared’ Chance – chicken cholera solution left exposed showed that germs were weakened by exposure to air Chance – chicken cholera solution left exposed showed that germs were weakened by exposure to air

Governments – P received money from French govt Governments – P received money from French govt Warfare - rivalry between Fr & Germany spurred on new discoveries Warfare - rivalry between Fr & Germany spurred on new discoveries Other reasons – better communications; pressure to improve agriculture led to anthrax vaccine Other reasons – better communications; pressure to improve agriculture led to anthrax vaccine

Plenary Plenary What do you think was the most important factor contributing to the development of germ theory? What do you think was the most important factor contributing to the development of germ theory?